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Found 1518 clinical trials
Study to Evaluate Efficacy and Safety of Elamipretide in Subjects With Primary Mitochondrial Disease From Nuclear DNA Mutations (nPMD) (NuPower) (NuPower)

SPIMD-301 is a 48-week, randomized, double-blind, parallel-group, placebo-controlled trial to assess efficacy and safety of single daily subcutaneous (SC) administration of elamipretide as a treatment for subjects with primary mitochondrial myopathy associated with nuclear DNA mutations (nPMD).

  • 0 views
  • 26 Sep, 2022
  • 16 locations
A Study of the Efficacy and Safety of 24 Week Treatment With REN001 in Patients With Primary Mitochondrial Myopathy (STRIDE)

This is a randomized, double-blind, placebo-controlled, parallel group, multi-centre, study designed to investigate the efficacy and safety of REN001 administered once daily over a 24-week period to patients with PMM.

  • 0 views
  • 23 Mar, 2022
  • 32 locations
PET Tau - Neurodegenerative Disease Imaging

in the brains of patients with injury to brain cells. This study looks at neurodegenerative diseases such as frontotemporal degeneration (FTD).

ct scan
dementia
cognitive impairment
neurodegenerative disorders
Accepts healthy volunteers
  • 21 views
  • 20 Apr, 2022
  • 1 location
Retinal Neuro-vascular Coupling in Patients With Neurodegenerative Disease

Alzheimer´s disease (AD) in one of the most important causes of dementia and poses a considerable challenge in health care. Today, criteria for the diagnosis and the follow up of patients with AD mainly rely either on subjective tests or invasive methods. This limits the general applicability of the latter …

cognitive impairment
neurodegenerative disorders
mild cognitive impairment
cognitive assessment
mini-mental state examination
  • 2 views
  • 24 Apr, 2022
  • 1 location
Tau PET Imaging With 18F-T807(AV1451) in Neurodegenerative Disorders

Alzheimer's disease, Parkinson's disease, and Huntington's disease are common neurodegenerative diseases. Tau is a microtubule-associated protein, and aggregated tau resulting from

parkinson's disease
  • 0 views
  • 01 Dec, 2021
  • 1 location
PET Imaging of Neuroinflammation in Neurodegenerative Diseases Via a Novel TSPO Radioligand

Background Aging-related progressive neurological disorders include frontotemporal dementia, Lou Gehrig s disease, and Alzheimer s disease. Little is known about what causes these disorders. Brain inflammation may be involved. Researchers want to see if scans using radioactive drugs can show brain inflammation. Objective To see if the drug [11C]ER176 can …

huntington's chorea
neurodegenerative disorders
neurological disorder
pittsburgh compound b
pick's disease
  • 28 views
  • 20 Jul, 2022
  • 1 location
Exploring the Recovery Function of Sleep in Neurodegeneration (RFSN)

The overall objective of this study is to identify the best approach for assessing the recovery function of sleep in neurodegenerative diseases associated with abnormal protein aggregation with

Accepts healthy volunteers
  • 3 views
  • 17 Jun, 2022
  • 1 location
Immunohistochemical Study of Peripheral Blood Mononuclear Cells in Sporadic Alzheimer's Disease and Dementia With Lewy Body

for specific diseases, and define these two neurodegenerative diseases with high precision from the level of molecular immunity. To provide basis for further study of the immunohistochemical

dementia
donepezil
neurodegenerative disorder
alzheimer's disease
Accepts healthy volunteers
  • 0 views
  • 14 Sep, 2022
  • 1 location
Quality of Life of Caregivers and Patients Suffering From Multiple System Atrophy (QUA2-AMS)

Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disorder that cause as other neurodegenerative diseases profound declines in functioning and thus, require caregiving for

Accepts healthy volunteers
  • 1 views
  • 25 Jan, 2022
  • 1 location
Exploratory Evaluation of [11C]MPC6827

This is a phase 0 study that will enable an assessment of biodistribution and estimation of absorbed dose in humans based on data collected from five healthy volunteers, which is typically the minimum number required by the FDA for first-in-human studies to assess dosimetry of a new tracer. The evaluation …

Accepts healthy volunteers
pregnancy testing
cognitive assessment
alzheimer's disease
  • 0 views
  • 20 Apr, 2022
  • 1 location