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Found 5876 clinical trials
Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients (CODEX)

Anesthesia is a drug induced, reversible, comatose state that facilitates surgery and it is widely assumed that cognition returns to baseline after anesthetics have been eliminated. However, many patients have persistent memory impairment for weeks to months after surgery. Cardiac surgery appears to carry the highest risk of postoperative cognitive …

postoperative cognitive dysfunction
coronary artery bypass graft
cognitive deficits
heart surgery
coma
  • 10 views
  • 28 Feb, 2022
  • 1 location
Mesenchymal Stem Cells for the Treatment of Various Chronic and Acute Conditions

This multi-arm, multi-site study investigates the safety, tolerability, and efficacy of stem cell therapy for the treatment of various acute and chronic conditions. Clinically observed initial findings and an extensive body of research indicate regenerative treatments are both safe and effective for the treatment of multiple conditions.

Accepts healthy volunteers
  • 158 views
  • 17 May, 2022
  • 1 location
Remote Ischemic Conditioning in Patients With Acute Stroke (RESIST) (RESIST)

Our primary aim is to investigate whether remote ischemic conditioning (RIC) as an adjunctive treatment can improve long-term recovery in acute stroke patients as an adjunct to standard treatment.

adjunctive treatment
limb ischemia
stroke
acute stroke
ischemia
  • 16 views
  • 26 Mar, 2022
  • 4 locations
Estimating Prevalence of Inherited Disorders of Sulfur Amino Acids Metabolism in Patients With Psychotic Disorders. (PsyNIT)

Screening for sulfur amino acid metabolism pathologies using a sulfitest in adult patients with psychotic disorder.

  • 0 views
  • 27 May, 2022
  • 1 location
The Impact of a Smartphone-based Personalized Intervention on Cognitive and Cerebrovascular Health in CIRCLE-CHINA

-monitoring and personalized feedback via smartphone app. The short-term primary outcome is 1-year change in global cognitive score measured by a modified National Institute of Neurological Disorders and

heart disease
Accepts healthy volunteers
hypertension
cognitive decline
nervous system disorder
  • 0 views
  • 24 Jan, 2022
  • 1 location
A Multicenter, Open-label, Extension Study to Evaluate the Long-term Safety and Tolerability of Oral Ubrogepant in the Acute Treatment of Migraine With or Without Aura in Children and Adolescents (Ages 6-17)

Migraine is a common neurological disorder typically characterized by attacks of throbbing, moderate to severe headache, often associated with nausea, vomiting, and sensitivity to light and

nausea
acute treatment
severe headache
headache
migraine in children
  • 19 views
  • 29 Oct, 2022
  • 75 locations
Phase 3, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Apitegromab (SRK-015) in Patients With Later-Onset Spinal Muscular Atrophy Receiving Background Nusinersen or Risdiplam Therapy (SAPPHIRE)

This Phase 3 trial (Study SRK-015-003) is being conducted in patients ≥2 years old at Screening, who were previously diagnosed with later-onset spinal muscular atrophy (SMA) (i.e., Type 2 and Type 3 SMA) and are receiving an approved survival motor neuron (SMN) upregulator therapy (i.e., either nusinersen or risdiplam), to …

risdiplam
nusinersen
  • 0 views
  • 23 Oct, 2022
  • 24 locations
Decoding Pain Sensitivity in Migraine With Multimodal Brainstem-based Neurosignature

Migraine is a highly prevalent and disabling neurological disease, which has a tremendous impact on sufferers, healthcare systems, and the economy. According to the 2016 WHO report, migraine is

  • 0 views
  • 24 Apr, 2021
  • 1 location
A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Single-attack Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Oral Ubrogepant in the Acute Treatment of Migraine With or Without Aura in Children and Adolescents (Ages 6-17)

Migraine is a common neurological disorder typically characterized by attacks of throbbing, moderate to severe headache, often associated with nausea, vomiting, and sensitivity to light and

nausea
acute treatment
severe headache
headache
migraine in children
  • 17 views
  • 21 Oct, 2022
  • 75 locations
A Phase III Study of the Impact of a Physical Activity Program on Disease-Free Survival in Patients With High-Risk Stage II or Stage III Colon Cancer: A Randomized Controlled Trial (CHALLENGE)

RATIONALE: Participating in a physical activity program designed to increase free time physical activity and receiving written health education materials may influence the chance of cancer recurring as well as impact on physical fitness, psychological well-being and the quality of life of patients who have undergone surgery and chemotherapy for …

fatigue
cancer treatment
cancer
exercise intervention
fatigue assessment and management
  • 598 views
  • 22 Oct, 2022
  • 47 locations