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Found 1051 clinical trials
Featured trial
A Phase 2, Open-Label, Single-Arm, Multicenter Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tumors Harboring Activating FGFR1-3 Alterations (FIGHT-209) (FIGHT-209)

This is an open-label, monotherapy study of pemigatinib in participants with recurrent glioblatoma (GBM) or other primary CNS tumors with an activating FGFR1-3 mutation or fusion/rearrangement. This study consists of 3 cohorts, Cohorts A, B, and C, and will enroll approximately 82, 82, and 25 participants into each cohort, respectively. …

oligodendroglioma
FGFR1
TERT
karnofsky performance status
ccnu
  • 3 views
  • 22 Oct, 2022
  • 27 locations
Featured trial
A Study to Assess the Safety of BIIB122 Tablets and if it Can Slow the Worsening of Early-Stage Parkinson's Disease in Participants Between the Ages of 30 and 80 (LUMA)

In this study, researchers will learn more about a study drug called BIIB122 in participants with early-stage Parkinson's disease (PD). In this study: Participants will take 225 milligrams (mg) of BIIB122 or a placebo as tablets by mouth. A placebo looks like the study drug but has no real medicine …

hoehn and yahr scale
movement disorder
  • 9 views
  • 17 Nov, 2022
  • 6 locations
Featured trial
A Study to Assess if BIIB122 Tablets Are Safe and Can Slow Worsening of Early-Stage Parkinson's Disease in Participants With Specific LRRK2 Genetic Variants Between the Ages of 30 and 80 Using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (LIGHTHOUSE)

In this study, researchers will learn more about a study drug called BIIB122 in participants with early-stage Parkinson's disease (PD). The study will focus on participants with a specific genetic variant in their LRRK2 gene. The main question researchers are trying to answer is if taking BIIB122 slows the worsening …

depression
motor symptoms
hoehn and yahr scale
movement disorder
  • 1 views
  • 16 Nov, 2022
  • 2 locations
Featured trial
Protective Role of Pre-/ Post-biotics on Gut Inflammation, Dysbiosis, and Life Quality in Rett Syndrome (Biotics_RTT) (Biotics_RTT)

The study will examine the potential efficacy and safety of two pre- and post-biotics on markers for gut inflammation and intestinal microbiota ecology in patients with Rett syndrome. Moreover, this trial will search for possible effects on epileptogenesis and quality of life.

seizure
  • 2 views
  • 11 Jul, 2022
  • 1 location
Featured trial
GAIN: GingipAIN Inhibitor for Treatment of Alzheimer's Disease

bacteria and its toxins in their central nervous system. This clinical trial evaluates whether the investigational drug COR388 is safe and can slow or stop the progression of Alzheimer’s Disease

senile plaques
  • 153 views
  • 08 Dec, 2020
  • 1 location
Featured trial
Clinical Validation of At-Home Methods of Sleep Assessment in Rett Syndrome

measure Blood Volume Pulse, sympathetic nervous system arousal, local skin temperature, as well as hand movements.Families can choose to participate in a second optional component

  • 0 views
  • 19 Jan, 2023
  • 1 location
Featured trial
A Research Study for Pentalogy of Cantrell

This study will collect blood, urine, and other tissue samples from patients with Pentalogy of Cantrell (POC) and other inherited diseases that may involve mutations in non-muscle myosin II-B heavy chain (MYH10). We will also collect samples from the relatives of affected individuals. POC is a very rare disorder in …

nervous system disorders
nervous system disease
congenital disorders
  • 19 views
  • 22 Dec, 2020
  • 1 location
Featured trial
ACNS1123: Phase 2 Trial of Response-Based Radiation Therapy for Patients With Localized Central Nervous System Germ Cell Tumors (CNS GCT)

ACNS1123: Phase 2 Trial of Response-Based Radiation Therapy for Patients With Localized Central Nervous System Germ Cell Tumors (CNS GCT)

  • 176 views
  • 08 Nov, 2020
  • 1 location
Featured trial
Advanced Non-Small Cell Lung Cancer

Advanced Non-Small Cell Lung Cancer

  • 138 views
  • 08 Nov, 2020
  • 1 location
Featured trial
Metastatic Colorectal Cancer with wild-type KRAS tumors.

Metastatic Colorectal Cancer with wild-type KRAS tumors.

  • 270 views
  • 25 Mar, 2021
  • 1 location