Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 156 clinical trials
A Phase 2/3, Multicenter, Randomized, Double-blind, Placebo-Controlled, Adaptive Design Study to Evaluate the Efficacy and Safety of MK-5475 in Adults With Pulmonary Arterial Hypertension

This is a two-part (Phase 2/Phase 3) study of MK-5475, an inhaled soluble guanylate cyclase stimulator, in participants with pulmonary arterial hypertension (PAH). The first part (Phase 2) will assess three different doses of MK-5475 compared to placebo in a base period of 12 weeks, followed by comparison of three …

pulmonary arterial hypertension
left ventricular end-diastolic pressure
right heart catheterization
heart disease
body mass index
  • 38 views
  • 20 Oct, 2022
  • 76 locations
The Prophet Trial -Pilot Study to Assess Safety and Efficacy of a Novel Atrial Flow Regulator (AFR) in Patients With Pulmonary Hypertension (AFR-Prophet)

This study aims to investigate safety and efficacy of Occlutech® AFR device in patients with severe pulmonary hypertension (PH).

pulmonary arterial pressure
heart failure
right ventricular failure
  • 46 views
  • 07 Oct, 2022
  • 12 locations
A Randomized, Multicenter, Double-Blind, Placebo-Controlled, Parallel-Group, Event-Driven, Group-Sequential Study With Open-Label Extension Period to Assess the Efficacy and Safety of Selexipag as Add-On Treatment to Standard of Care in Children Aged >=2 to <18 Years With Pulmonary Arterial Hypertension (SALTO)

The purpose of this study is to evaluate whether the addition of selexipag to standard of care treatment delays disease progression in children with Pulmonary Arterial Hypertension (PAH) in comparison to placebo.

endothelin
pulmonary arterial hypertension
right heart catheterization
heart disease
primary pulmonary hypertension
  • 247 views
  • 25 Oct, 2022
  • 84 locations
Physiological-based Cord Clamping in Congenital Diaphragmatic Hernia (PinC)

Pulmonary hypertension is a major determinant of postnatal survival in infants with a congenital diaphragmatic hernia (CDH). The current care during the perinatal stabilisation period in infants born with this rare birth defect might contribute to the development of pulmonary hypertension after birth - in particular umbilical cord clamping before …

umbilical cord clamping
pulmonary hypoplasia
diaphragmatic hernia
hypertension
congenital diaphragmatic hernia
  • 0 views
  • 12 Jul, 2022
  • 5 locations
A Study of Ralinepag to Evaluate Effects on Exercise Capacity by CPET in Subjects With WHO Group 1 PH (CAPACITY)

Study ROR-PH-302, ADVANCE CAPACITY, is designed to evaluate the effects of ralinepag therapy on exercise capacity as assessed by change in peak oxygen consumption (VO2) derived from cardiopulmonary exercise testing (CPET) after 28 weeks of treatment

endothelin
ralinepag
diuretics
exercise stress test
cardiopulmonary exercise testing
  • 4 views
  • 04 Oct, 2022
  • 36 locations
XELOX for 4 Months Versus 6 Months in Gastric Cancer (LOMAC)

Our study aims to compare the efficacy and safety of capecitabine and oxaliplatin for 4 months versus 6 months as adjuvant chemotherapy after D2 Gastrectomy in patients with gastric cancer. Hypothesis: For gastric patients after D2 Gastrectomy, capecitabine and oxaliplatin for 4 months show noninferiority to capecitabine and oxaliplatin for …

adenocarcinoma
immunostimulants
capecitabine
cancer chemotherapy
oxaliplatin
  • 33 views
  • 22 Jan, 2021
  • 10 locations
Randomized Comparison Between Sentinel Lymph Node Biopsy and Lymph Node Dissection in Early Stage Endometrial Cancer (SELYE)

Through this clinical trial, the investigators aim to verify the usefulness and stability of sentinel lymph node mapping in endometrial cancer of clinical stage I-II.

carcinosarcoma
adenocarcinoma
uterine disease
cancer
hysterectomy
  • 0 views
  • 12 Mar, 2022
  • 1 location
PrEvention of Posttraumatic Joint contractuRes With Ketotifen 2 (PERK2)

PrEvention of posttraumatic contractuRes with Ketotifen 2 (PERK 2) is a Phase III randomized, controlled, double blinded multicenter trial with 3 parallel groups (Ketotifen 2 mg or 5 mg or lactose placebo twice daily orally for 6 weeks) and a primary endpoint of elbow extension-flexion range of motion (ROM) arc …

  • 60 views
  • 16 Oct, 2022
  • 15 locations
Low or High Ligation of the IMA With Apical Lymph Node Dissection in Rectal Cancer Laparoscopic Surgery

Laparoscopy colon surgery is accepted worldwide in the recent years. But there is still argument on the effect of laparoscopy rectal surgery. Laparoscopy has advantages on showing the inferior mesenteric artery (IMA), protection of autonomic nerve, low rectal anastomosis, and total mesorectum excision. However, debate on the level of IMA …

adenocarcinoma
rectal anastomosis
fluorouracil
metastasis
rectal surgery
  • 0 views
  • 25 Feb, 2022
  • 1 location
STaR (Surgical Timing and Rehabilitation) Trial for Multiple Ligament Knee Injuries

The purpose of this study is to investigate effects of timing of surgery (early vs. delayed) and timing of post-operative rehabilitation (early vs. delayed) for the treatment of military personnel and civilians that sustain a multiple ligament knee injury. To achieve this overall objective of this project, we will conduct …

  • 169 views
  • 15 Oct, 2022
  • 1 location