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Found 1547 clinical trials
A Prospective Comparison Between Ureteral Stent and Nephrostomy Tube for an Urgent Drainage of Obstructed Kidney

Kidney obstruction might be caused by a stone in the urinary tract. In case of accompanying fever or renal failure, an urgent drainage might be needed. This can be done either by placing an ureteral stent or a nephrotomy tube. Only limited number of studies examined the question which of …

renal failure
  • 6 views
  • 07 Nov, 2020
  • 1 location
Pharmacokinetic Study on the Combination of Everolimus-Tacrolimus

The purpose of this study is to address the pharmacokinetic (PK) profiles of everolimus and tacrolimus in combination in de novo kidney transplant recipients, comparing 1.5 and 3 mg per day of everolimus in fixed doses. For comparison purposes, pharmacokinetic profiles will be performed at first dose (abbreviated), 4th day, …

kidney transplant
tacrolimus
  • 13 views
  • 07 Nov, 2020
  • 1 location
Reduction or Discontinuation of CNI's With Conversion to Everolimus-Based Immunosuppresion

This study is design to compare two different strategies aiming to lessen the degree of the ongoing process of allograft injury either by removing tacrolimus from the maintenance immunosuppressive protocol or by reducing tacrolimus dose. The primary goal is to assess the change in renal function at 6 and 12 …

immunosuppressive agents
tacrolimus
renal impairment
kidney biopsy
  • 11 views
  • 07 Nov, 2020
  • 1 location
A Study of RGLS4326 in Patients With Autosomal Dominant Polycystic Kidney Disease

Primary Objective To assess the dose response relationship between RGLS4326 and ADPKD biomarkers Secondary Objectives To characterize the pharmacokinetic (PK) properties of RGLS4326 in plasma and urine To assess the safety and tolerability of RGLS4326

  • 0 views
  • 03 May, 2021
  • 12 locations
Safety of Lixivaptan in Subjects Previously Treated With Tolvaptan for Autosomal Dominant Polycystic Kidney Disease

This is a Phase 3, open-label, repeat-dose study designed to assess liver safety, non-liver safety, and efficacy in subjects who previously experienced liver chemistry test abnormalities while treated with tolvaptan and were permanently discontinued from the drug for that reason. Up to 50 eligible subjects will be enrolled and treated …

body mass index
renal disease
tolvaptan
hypertension
chronic kidney disease
  • 0 views
  • 03 May, 2021
  • 9 locations
Comprehensive Management of Diabetic Patients With Renal Impairment : Impact on Blood Pressure and Glycemic Control

Diabetes is the leading cause of end-stage renal disease in developed countries. Hypertension and metabolic control are known to affect the progression of renal deficiency and patient's

nephropathy
hypertension
diabetes
renal failure
  • 10 views
  • 07 Nov, 2020
  • 1 location
Study Evaluating Denosumab on Bone and Vascular Metabolism in Osteoporotic Chronic Kidney Disease

Aim of this study is to evaluate in a population of old osteoporotic chronic kidney disease females the effect of denosumab: on bone mineral density (femoral T-score) at 24 months

  • 10 views
  • 25 Jan, 2021
  • 10 locations
Clinical Study of Umbilical Cord Mesenchymal Stem Cells in the Treatment of Type 2 Diabetic Nephropathy

follow-up.To observe the efficacy and safety of umbilical cord mesenchymal stem cell infusion in Chinese patients with type 2 diabetic nephropathy who received traditional hypoglycemic therapy.

  • 0 views
  • 27 Jan, 2021
  • 1 location
A Study of YPEG-rhEPO in Patients Suffered From Anemia Due to Chronic Kidney Disease

Chronic Kidney Disease (CKD) as assessed by hemoglobin maintenance, adverse events and health-related quality of life.

  • 0 views
  • 26 May, 2021
  • 17 locations
Adipose-derived Stem Cells (ADSCs) for Moderate to Severe Chronic Kidney Disease

To assess the safety of allogeneic injection of expanded ADSCs to patients with Moderate to Severe Chronic Kidney Disease To assess the efficacy of allogeneic injection of

  • 6 views
  • 26 Jan, 2021
  • 2 locations