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Found 1572 clinical trials
Study of NGM707 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies

Study of NGM707 as Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies

pembrolizumab
  • 0 views
  • 23 Jun, 2021
  • 2 locations
CPI-006 Alone and in Combination With Ciforadenant and With Pembrolizumab for Patients With Advanced Cancers

This is a Phase 1/1b open-label, dose escalation and dose expansion study of CPI-006, a humanized monoclonal antibody (mAb) targeting the CD73 cell-surface ectonucleotidase in adult subjects with select advanced cancers. CPI-006 will be evaluated as a single agent, in combination with ciforadenant (an oral adenosine 2A receptor antagonist), in …

bladder tumor
monoclonal antibodies
measurable disease
sarcoma
colorectal neoplasm
  • 1241 views
  • 05 Aug, 2021
  • 27 locations
Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies

This is a single arm, open-label, uni-center, phase I-II study to evaluate the safety and effectiveness of CAR-T/TCR-T cell immunotherapy in treating with different malignancies patients.

apheresis
blood urea nitrogen
cancer
flow cytometry
c-MET
  • 209 views
  • 24 Jan, 2021
  • 1 location
Safety and Efficacy of KY1044 and Atezolizumab in Advanced Cancer

A Phase 1/2, open label, multi-center study to evaluate the safety, efficacy and tolerability of KY1044 as single agent and in combination with anti-PD-L1 (atezolizumab) in adult patients with selected advanced malignancies, who are ineligible for or there are no available therapies known to confer a clinical benefit for their …

monoclonal antibodies
measurable disease
pd-l1
squamous cell carcinoma
cancer
  • 89 views
  • 06 Jul, 2021
  • 11 locations
FT500 as Monotherapy and in Combination With Immune Checkpoint Inhibitors in Subjects With Advanced Solid Tumors

FT500 is an off-the-shelf, iPSC-derived NK cell product that can bridge innate and adaptive immunity, and has the potential to overcome multiple mechanisms of immune checkpoint inhibitor (ICI) resistance. The preclinical data provide compelling evidence supporting the clinical investigation of FT500 as monotherapy and in combination with ICI in subjects …

interleukin 2
lymphoma
measurable disease
cancer
atezolizumab
  • 119 views
  • 26 Jan, 2021
  • 4 locations
PAN-study: Pan-Cancer Early Detection Study (PAN)

The PAN-cancer Early Detection study or PAN-study is a prospective cross-sectional observational case-control study evaluating whether Breath Biopsy can differentiate between patients with and without different cancer types by comparing breath biomarkers for a range of cancer types including patients with gastric, oesophageal, and liver cancer. The research may be …

bladder tumor
cancer
bladder cancer
cystoscopy
hematuria
  • 15 views
  • 31 May, 2021
  • 1 location
Auto Transplant for High Risk or Relapsed Solid or CNS Tumors

This is a standard of care treatment guideline for high risk or relapsed solid tumors or CNS tumors consisting of a busulfan, melphalan, thiotepa conditioning (for solid tumors) or carboplatin and thiotepa conditioning (for CNS tumors) followed by an autologous peripheral blood stem cell transplant. For solid tumors, if appropriate, …

lymphoma
atypical teratoid/rhabdoid tumor
human chorionic gonadotropin
renal neoplasm
cancer
  • 77 views
  • 02 Jun, 2021
  • 1 location
Understanding Communication in Healthcare to Achieve Trust (U-CHAT)

Honest, clear, and empathetic communication between pediatric oncologists (POs) and parents of children with cancer (POCCs) is imperative to facilitating therapeutic alliance and ensuring that medical management aligns with the families' goals of care. Communication is particularly important during conversations about disease reevaluation, which often necessitate parental decision-making in the …

cancer
glioblastoma multiforme
brain tumor
solid tumor
  • 46 views
  • 29 Aug, 2021
  • 1 location
Investigation of the Genetics of Hematologic Diseases

The purpose of this study is to collect and store samples and health information for current and future research to learn more about the causes and treatment of blood diseases. This is not a therapeutic or diagnostic protocol for clinical purposes. Blood and bone marrow as well as health information …

blood disorder
sickle cell disease
sickle cell anemia
hydroxyurea
hematologic disorder
  • 94 views
  • 06 Aug, 2021
  • 1 location
Eliminating the Need for Pancreas Biopsy Using Peripheral Blood Cell-free DNA

Donor-derived cell-free DNA (dd-cfDNA) has shown promise as an early marker for cellular injury caused by rejection. dd-cfDNA changes may also indicate other injuries that lead to progressive decline in transplant organ function associated with, in the case of kidney transplantation, the presence of interstitial fibrosis (IF) and tubular atrophy …

  • 5 views
  • 07 May, 2021
  • 1 location