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Found 1575 clinical trials
Safety Tolerability Pharmacokinetics and Pharmacodynamics of INCB099318 in Participants With Advanced Solid Tumors

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics, and pharmacodynamics of INCB099318 in select solid tumors.

  • 0 views
  • 06 Aug, 2021
  • 3 locations
Multicenter Prospective Study for Urinary Exosomal Biomarkers of Kidney Allograft Tubulointerstitial Fibrosis

The investigators aim to identify urinary exosomal biomarkers that represent the extent of graft fibrosis from deceased donor kidney transplantation. Urinary samples will be collected from deceased kidney donors at the time of procurement and zero-day kidney graft biopsy will be performed at the time of transplant. The association between …

  • 0 views
  • 23 Jan, 2021
  • 1 location
Long-term Outcomes of Chronic Hepatitis C Patients Post Sofosbuvir-based Treatment

Primary Objective: To evaluate the long-term outcomes including liver related morbidity, mortality and hepatocellular carcinoma (HCC) development as compared to those of historical control with interferon(IFN)-based treatment. Secondary Objective: To access liver fibrosis progression/regression in CHC patients after sofosbuvir-based treatment. To investigate the long-term outcomes of extrahepatic manifestations of the …

carcinoma
fibrosis
hepatitis
ribavirin
interferon
  • 40 views
  • 23 Jan, 2021
  • 18 locations
Exploring the Anti-inflammatory Properties of Cannabis and Their Relevance to Insulin Sensitivity

This study tests the effects of cannabinoid levels in blood on inflammation and insulin sensitivity both acutely and chronically in individuals across the weight spectrum. To that end, the study employs two observational designs: 1) A study of acute effects with intermittent cannabis users and 2) A study in which …

insulin
insulin sensitivity
insulin resistance
fasting
cannabinoids
  • 33 views
  • 05 Jun, 2021
  • 1 location
Distribution and Clinical Implication of CMD in Patients With HFpEF Without Significant CAD

To evaluate the incidence of coronary microvascular dysfunction (CMD) and its' prognostic implication in patients who have diagnosed as heart failure with preserved ejection fraction (HFpEF) confirmed by HFA-PEFF scoring system without functionally significant coronary artery disease.

  • 0 views
  • 18 Mar, 2021
  • 1 location
Study of NGM707 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies

Study of NGM707 as Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies

pembrolizumab
  • 0 views
  • 23 Jun, 2021
  • 2 locations
CPI-006 Alone and in Combination With Ciforadenant and With Pembrolizumab for Patients With Advanced Cancers

This is a Phase 1/1b open-label, dose escalation and dose expansion study of CPI-006, a humanized monoclonal antibody (mAb) targeting the CD73 cell-surface ectonucleotidase in adult subjects with select advanced cancers. CPI-006 will be evaluated as a single agent, in combination with ciforadenant (an oral adenosine 2A receptor antagonist), in …

lung cancer
breast cancer
measurable disease
solid tumour
lung carcinoma
  • 1241 views
  • 05 Aug, 2021
  • 27 locations
Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies

This is a single arm, open-label, uni-center, phase I-II study to evaluate the safety and effectiveness of CAR-T/TCR-T cell immunotherapy in treating with different malignancies patients.

blood test
apheresis
ny-eso-1
renal function
cyclophosphamide
  • 209 views
  • 24 Jan, 2021
  • 1 location
A Study of XmAb 22841 Monotherapy & in Combination w/ Pembrolizumab in Subjects w/ Selected Advanced Solid Tumors

This is a Phase 1, multiple dose, ascending-dose escalation study and expansion study designed to define a maximum tolerated dose and/or recommended dose of XmAb22841 monotherapy and in combination with pembrolizumab; to assess safety, tolerability, pharmacokinetics, immunogenicity, and anti-tumor activity of XmAb22841 monotherapy and in combination with pembrolizumab in subjects …

programmed cell death 1 ligand 1
fallopian tube
ovarian cancer
gastroesophageal junction adenocarcinoma
urothelial carcinoma
  • 671 views
  • 28 Aug, 2021
  • 32 locations
Study of ADCT-301 in Patients With Selected Advanced Solid Tumors

This study evaluates ADCT-301 in patients with Selected Advanced Solid Tumors. Patients will participate in a Treatment Period with 3-week cycles and a Follow-up Period every 12 weeks for up to 1 year after treatment discontinuation.

pancreatic cancers
fallopian tube
blood transfusion
platelet count
solid tumour
  • 73 views
  • 22 Jul, 2021
  • 6 locations