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Found 1574 clinical trials
Cancer in Inherited Bone Marrow Failure Syndromes

Background A prospective cohort of Inherited Bone Marrow Failure Syndrome (IBMFS) will provide new information regarding cancer rates and types in these disorders. Pathogenic variant(s) in IBMFS genes are relevant to carcinogenesis in sporadic cancers. Patients with IBMFS who develop cancer differ in their genetic and/or environmental features from patients …

chromosome breakage
cancer
neutropenia
thrombocytopenia
synostosis
  • 43 views
  • 26 Sep, 2021
  • 1 location
Study of Genes and Environment in Patients With Cancer in East Anglia Trent or West Midlands Regions of the United Kingdom

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This study is looking at genetic susceptibility to cancer and interactions between genes and the environment in patients with cancer …

cancer
  • 64 views
  • 07 Nov, 2020
  • 1 location
SELF-BREATHE RCT for Chronic Breathlessness

A feasibility RCT comprising two groups: Intervention (SELF-BREATHE in addition to standard NHS care) Control group (standard / currently available NHS care)

heart failure
fibrosis
pulmonary disease
cancer
COPD
  • 0 views
  • 17 Sep, 2021
  • 1 location
International PPB/DICER1 Registry

Pleuropulmonary blastoma (PPB) is a rare malignant neoplasm of the lung presenting in early childhood. Type I PPB is a purely cystic lesion, Type II is a partially cystic, partially solid tumor, Type III is a completely solid tumor. Treatment of children with PPB is at the discretion of the …

cancer
initial diagnosis
cancer chemotherapy
solid tumor
sarcoma
  • 37 views
  • 08 Aug, 2021
  • 1 location
A Study to Evaluate the Safety and Tolerability of AB154 in Participants With Advanced Malignancies

This is a Phase 1, multicenter, open-label, dose-escalation study to evaluate the safety, tolerability, PK, PD, and clinical activity of domvanalimab (AB154) as monotherapy and in combination with zimberelimab (AB122) in participants with advanced solid malignancies.

corticosteroids
immunosuppressants
hepatitis
major surgery
prednisone
  • 160 views
  • 02 Aug, 2021
  • 21 locations
PF-06952229 Treatment in Adult Patients With Advanced Solid Tumors

A Phase 1 dose escalation and expansion study evaluating safety, tolerability and pharmacokinetics of PF-06952229 in adult patients with advanced solid tumors.

adenocarcinoma
progesterone receptor
letrozole
formalin-fixed paraffin-embedded
metastasis
  • 58 views
  • 21 Sep, 2021
  • 23 locations
Nivolumab (Opdivo ) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers

This study investigates the safety/toxicity and potential anti-tumor activity of sequential administration of nivolumab and escalating doses of the mTOR inhibitor ABI-009 in advanced Ewing's sarcoma, PEComa, epithelioid sarcoma, desmoid tumor, chordoma, non-small cell lung cancer, small cell lung cancer, urethelial carcinoma, melanoma, renal cell carcinoma, squamous cell carcinoma of …

advanced sarcoma
pd-1 inhibitor
desmoid tumor
human chorionic gonadotropin
lymphoma
  • 82 views
  • 15 May, 2021
  • 1 location
A Study of DSP-7888 Dosing Emulsion in Combination With Immune Checkpoint Inhibitors in Adult Patients With Advanced Solid Tumors

This is a Phase 1b/2, open-label, multicenter study of DSP-7888 Dosing Emulsion in combination with checkpoint inhibitors (nivolumab or pembrolizumab) in adult patients with solid tumors, that consists of 2 parts: dose search part of the study (Phase 1b and Phase 1b Enrichment Cohort) and the dose expansion part of …

adenocarcinoma
gilbert's syndrome
metastatic melanoma
systemic therapy
immunomodulator
  • 59 views
  • 15 Sep, 2021
  • 25 locations
Phase 1 Study of CK-301 (Cosibelimab) as a Single Agent in Subjects With Advanced Cancers

CK-301 (cosibelimab) is a fully human monoclonal antibody of IgG1 subtype that directly binds to Programmed Death-Ligand 1 (PD-L1) and blocks its interactions with the Programmed Death-1 (PD-1) and B7.1 receptors. The primary objectives of this study are to assess the safety, tolerability and efficacy of CK-301 when administered intravenously …

pd-l1
metastatic melanoma
endometrial carcinoma
lymphoma
squamous cell carcinoma
  • 1814 views
  • 22 Mar, 2021
  • 47 locations
B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

This is a phase I, open-label, non-randomized study that will enroll pediatric and young adult research participants with relapsed or refractory non-CNS solid tumors to evaluate the safety, feasibility, and efficacy of administering T cell products derived from the research participant's blood that have been genetically modified to express a …

cetuximab
cytokine release syndrome
mibg
solid tumour
cytokines
  • 0 views
  • 27 Apr, 2021
  • 1 location