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Found 112 clinical trials
Post Approval Study for Treatment of Drug-resistant Adult and Pediatric Primary FSGS Using the LIPOSORBER® LA-15 System (FSGS all age)

This multicenter, prospective, single-arm clinical study will evaluate the probable benefit and safety of the LIPOSORBER® LA-15 System for the treatment of adult patients with nephrotic syndrome associated with primary focal segmental glomerulosclerosis, when the standard treatment options, including corticosteroid and/or calcineurin inhibitors treatments, have been unsuccessful or not well …

plasma cholesterol
corticosteroids
kidney transplant
primary focal segmental glomerulosclerosis
nephrotic syndrome
  • 93 views
  • 18 Apr, 2022
  • 10 locations
PRI-VENT FSGS: Preemptive Rituximab to Prevent Recurrent Focal Segmental Glomerulosclerosis Post-Transplant

This is a phase III, multicenter, randomized, open label, clinical trial to test that hypothesis that plasmapheresis plus rituximab prior to kidney transplantation can prevent recurrent FSGS in children and adults.

kidney transplant
monoclonal antibodies
obesity
arrhythmias
rituximab
  • 102 views
  • 12 Feb, 2022
  • 14 locations
Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in Children (FSGS pediatric)

Liposorber® LA-15 System is a blood purification therapy that selectively removes malignant lipoproteins including low density lipoprotein from circulating blood flow and rapidly reduces the plasma cholesterol level. The system was originally developed for the treatment of patients with serious dyslipidemia such as familial hypercholesterolemia and then applied to improve …

plasma cholesterol
corticosteroids
kidney transplant
primary focal segmental glomerulosclerosis
nephrotic syndrome
  • 36 views
  • 20 Apr, 2022
  • 10 locations
A Pilot Randomized Clinical Trial of Transcutaneous Auricular Vagus Nerve Stimulation for the Treatment of Steroid Resistant Nephrotic Syndrome in Children (kidNEY-VNS)

Children with steroid resistant nephrotic syndrome (SRNS) are exposed to prolonged courses of immunosuppressant medications. Given the adverse side effect profiles and variable efficacy of these medications, there is an urgent need to identify novel and safe therapies to treat nephrotic syndrome in children. Stimulation of the vagus nerve, which …

  • 0 views
  • 22 Oct, 2022
  • 2 locations
Efficacy and Safety of VB119 in Subjects With Minimal Change Disease (MCD) and Focal Segmental Glomerulosclerosis (FSGS)

Phase 2, multi-center, proof-of-concept study to evaluate the safety and efficacy of VB119 on the maintenance of remission and duration of response in adults with primary MCD or primary FSGS who previously responded to steroid therapy.

corticosteroids
steroid treatment
steroid therapy
prednisone
minimal change disease
  • 0 views
  • 04 Oct, 2022
  • 8 locations
Tumor Necrosis Factor Inhibition in Focal Segmental Glomerulosclerosis and Treatment Resistant Minimal Change Disease

The researchers are testing adalimumab, a treatment which blocks tumor necrosis factor (TNF), to see if it changes levels of urine biomarker levels (TIMP1 and MCP1). The outcomes may help develop individualized treatment options for future patients with TNF driven Focal segmental glomerulosclerosis (FSGS) or minimal change disease (MCD).

ace inhibitor
immunosuppression
steroid treatment
angiotensin
steroid therapy
  • 12 views
  • 04 Oct, 2022
  • 3 locations
Interview Study of Adult and Child Patients and Parents of Children With Swelling Due to Nephrotic Syndrome. (Prepare-NS)

Researchers from the University of Michigan and Northwestern University are studying people's experiences with swelling caused by Nephrotic Syndrome. Interviews with patients (child and adult) and parents of young children will be conducted. The information collected from the interviews will be used to develop a survey to use when testing …

kidney transplant
swelling
nephrotic syndrome
glomerular filtration rate
nephropathy
  • 0 views
  • 04 Oct, 2022
  • 1 location
Study of the Safety and Efficacy of OMS721 in Patients With Immunoglobulin A (IgA) Nephropathy

The purpose of this study is to evaluate the safety and efficacy of OMS721 in patients with IgA nephropathy. The study will assess proteinuria by 24-hour urine protein excretion (UPE) in g/day at 36 weeks from beginning of treatment.

immunoglobulin a
immunoglobulins
glomerular filtration rate
nephropathy
proteinuria
  • 486 views
  • 05 Mar, 2022
  • 30 locations
Open-Label Extension Study of BION-1301 in IgA Nephropathy

This is an open-label extension (OLE) study to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD), and clinical activity of BION-1301 in adults with IgA nephropathy

  • 12 views
  • 28 Jan, 2021
  • 1 location
Autoreactive B Cells in Membranous Nephropathy

Membranous nephropathy (MN) is the most frequent cause of nephrotic syndrome (NS) in adults. The majority of MN patients show detectable circulating antibodies against the M-type phospholipase A2 receptor (PLA2R). Infusion of anti-CD20 monoclonal antibodies results in a profound depletion of B-cells, which are thought to be responsible for anti-PLA2R …

nephropathy
monoclonal antibodies
remission
Accepts healthy volunteers
  • 0 views
  • 02 Dec, 2021
  • 1 location