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Found 113 clinical trials
Mesenchymal Stromal Cells (MSC´s) in Renal Lupus (MSC-ROLE)

Phase II Clinical Trial to Assess the dose-response and Efficacy of Umbilical Cord-derived Mesenchymal Stromal Cells (MSCs) in Severe Renal Systemic Lupus Erythematosus (SLE).

nephropathy
cyclophosphamide
systemic lupus erythematosus
anti-dna antibodies
kidney biopsy
  • 52 views
  • 03 Feb, 2022
  • 2 locations
  • 0 views
  • 20 Aug, 2022
  • 3 locations
A Phase 2 Open-label Trial Evaluating the Efficacy and Safety of Daratumumab in Treatment of Patients With Active Lupus Nephritis

The purpose of this research is to study the safety and efficacy of daratumumab in inducing complete or partial remission in patients with active lupus nephritis.

remission
nephritis
proteinuria
mammogram
  • 0 views
  • 19 Sep, 2022
  • 1 location
A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Immune Nephritis

A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Immune Nephritis

nephritis
  • 0 views
  • 30 Oct, 2021
  • 1 location
An Open-Label, Long-term Study of GFB-887 in Patients With Glomerular Kidney Diseases

This is an open-label Phase 2 study evaluating the long term safety and tolerability of GFB-887 in patients with focal segmental glomerulosclerosis (FSGS), and treatment-resistant minimal change disease (TR-MCD)

proteinuria
segmental glomerulosclerosis
minimal change disease
glomerulosclerosis
focal segmental glomerulosclerosis
  • 0 views
  • 16 Sep, 2022
  • 17 locations
Induction Therapy for Lupus Nephritis With no Added Oral Steroids: A Trial Comparing Oral Corticosteroids Plus Mycophenolate Mofetil (MMF) Versus Obinutuzumab and MMF

This is a randomised, open label, controlled non-inferiority phase III multicentre trial. As primary objective, the study aims to demonstrate that a regimen free of additional oral corticosteroids but with obinutuzumab (and MMF) is non-inferior to a regimen based on oral corticosteroids and MMF in achieving the primary outcome of …

lupus
nephritis
kidney function tests
renal function
mammogram
  • 0 views
  • 18 Dec, 2021
  • 1 location
Bortezomib for Treating Glomerular Diseases

Bortezomib is a proteasome inhibitor that inhibits autoantibody production, and reduces podocyte damage and mesangial hyperplasia caused by NF-κB activation in the kidney. Literature has reported that bortezomib can achieve a complete response rate of up to 38% in the treatment of glomerular diseases, but its safety and effectiveness remain …

glomerular filtration rate
nephropathy
proteinuria
dexamethasone
  • 0 views
  • 05 Jun, 2022
  • 1 location
Prednisolone Treatment in Acute Interstitial Nephritis

A Prospective randomized trial with a primary objective to investigate the effect ofprdenisolone treatment in acute interstitial nephritis

  • 0 views
  • 27 Jan, 2021
  • 1 location
A Study of the Safety and Activity of Sparsentan for the Treatment of Incident Patients With Immunoglobulin A Nephropathy (SPARTAN)

To determine the nephroprotective potential of treatment with sparsentan in patients newly-diagnosed with immunoglobulin A nephropathy (IgAN) (ie, incident patients) who have not received prior angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) therapy.

immunoglobulin a
nephropathy
proteinuria
enzyme inhibitor
angiotensin
  • 4 views
  • 03 Jun, 2022
  • 1 location
Belimumab With Rituximab for Primary Membranous Nephropathy

treat MN. Treatment with a combination of belimumab and rituximab has not been studied in individuals with MN, but it is currently being tested in other autoimmune diseases, including lupus nephritis

rituximab
lupus
mammogram
monoclonal antibody
angiotensin
  • 340 views
  • 12 Sep, 2021
  • 11 locations