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Found 115 clinical trials
An Extended Access Program to Assess Long Term Safety of Bardoxolone Methyl in Patients With Chronic Kidney Disease (EAGLE)

This extended access study will assess the long-term safety and tolerability of bardoxolone methyl in qualified patients with chronic kidney disease (CKD) who previously participated in one of the qualifying clinical studies with bardoxolone methyl. Patients will remain in the study until bardoxolone methyl is available through commercial channels or …

renal failure
nephropathy
chronic kidney disease
renal disease
  • 211 views
  • 17 Sep, 2022
  • 65 locations
Recovering Damaged Cells for Sequelae Caused by COVID-19 SARS-CoV-2

Post-acute sequelae of SARS-CoV-2 infection can cause multiple system function disorders, and complicated symptoms last for an extended period. The virus can cause this continued infection, or the virus causes immune system function disorder and post-infectious autoimmune disease. The clinical symptoms can be smell loss, taste loss to liver function …

  • 25 views
  • 02 Jun, 2021
  • 1 location
VIBRANT: VIB4920 for Active Lupus Nephritis (VIBRANT)

participants with active lupus nephritis (LN).

prednisone
nephritis
mycophenolate
  • 0 views
  • 25 Jul, 2022
  • 1 location
ACTHar in the Treatment of Lupus Nephritis

patients experience inflammation in the kidneys. The purpose of this study is to determine the effectiveness and safety of two dosing arms of ACTHar gel in treating proliferative Lupus Nephritis (LN). This

acthar
kidney biopsy
nephritis
systemic lupus erythematosus
cellcept
  • 335 views
  • 21 Jan, 2021
  • 1 views
  • 05 May, 2022
  • 1 location
Minimizing Glucocorticoid Administration in Patients With Proliferative Lupus Nephritis (GLUREDLUP)

The aim of the study is to evaluate the efficacy of a therapeutic regimen which decreases glucocorticoid exposure compared with standard therapy in patients with proliferative lupus nephritis

prednisolone
azathioprine
rituximab
treatment regimen
cyclophosphamide
  • 0 views
  • 11 Mar, 2022
  • 1 location
Pre-emptive Treatments in Lupus Nephritis Patients With Serological Reactivation

The optimal management of asymptomatic serological reactivation (ASR) in lupus nephritis (LN) patients remained undefined. This project aims to investigate the impact of pre-emptive treatment on

nephritis
prednisolone
  • 0 views
  • 08 Aug, 2022
  • 2 locations
Efficacy and Safety of Tacrolimus Versus Mycophenolate in Lupus Nephritis

Prospective, randomized, parallel-group controlled, open-label, international (Asian) multicenter, comparison of corticosteroids combined with TAC and corticosteroids combined with MMF.

hematuria
corticosteroids
nephritis
proteinuria
tacrolimus
  • 67 views
  • 26 May, 2022
  • 1 location
Per-protocol Repeat Kidney Biopsy in Incident Cases of Lupus Nephritis (REBIOLUP)

Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus (SLE). Among people living with SLE, 35-60% will develop LN during the course of the disease. This

angiotensin receptor blockers
cyclophosphamide
hydroxychloroquine
calcineurin inhibitors
kidney biopsy
  • 0 views
  • 07 Jul, 2022
  • 1 location
Study of ALXN2050 in Proliferative Lupus Nephritis (LN) and Immunoglobulin A Nephropathy (IgAN)

This is a Phase 2, randomized, double-blind, placebo-controlled, multicenter study of ALXN2050 (120 and 180 milligrams [mg]) in addition to background therapy consistent with the standard of care in adult participants (≥ 18 to ≤ 75 years of age) with either LN or IgAN. The study will consist of an …

microscopic examination
enzyme inhibitor
immunosuppression
nephritis
proteinuria
  • 0 views
  • 30 Apr, 2022
  • 4 locations