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Found 115 clinical trials
Efficacy of Corticosteroids in Reducing Renal Scarring in Acute Pyelonephritis in Children

Urinary tract infection (UTI) is the most frequently occurring serious bacterial infection in young children and accounts 5 to 14% of emergency department visits Formation of renal scarring in children has been associated with serious complications as hypertension, preeclampsia, and end stage renal failure in young age . So, this …

Accepts healthy volunteers
acute pyelonephritis
  • 29 Apr, 2022
  • 1 location
PRediction Of Flares In Lupus With autoantibodiEs and Chemokines (PROFILE)

Rationale: Systemic lupus erythematosus (SLE) is a chronic relapsing-remitting autoimmune disease with a wide range of clinical manifestations affecting several organs. Although the management of lupus patients has improved in the last years, accurate models for predicting disease progression are lacking. Objective: To prospectively evaluate the predictive value of a …

  • 03 Jun, 2022
  • 1 location
The Lupus prEGnAnCY Cohort: An International Prospective Cohort of Lupus Pregnancies (LEGACY)

The goal is to evaluate adverse pregnancy outcomes (APO), their predictors and potential preventive therapies, such as aspirin (ASA). The investigator aims to improve the outcomes for women with SLE and offsprings. By quantifying the risk of APO conferred by clinical risk factors that can be assessed early in pregnancy …

inflammatory disorder
  • 11 Jul, 2022
  • 2 locations
Immune Checkpoint Inhibitors Nephrotoxicity

In recent years, immunotherapy has been postulated as one of the most effective strategy in the fight against cancer. The greatest success in this field has been achieved through the inhibition of molecules involved in the brake of the adaptive immune response. The compounds capable of blocking the action of …

  • 10 Aug, 2022
  • 2 locations
Correlation Vitamin D Level to Endocrine Autoimmune Toxicity Due to Immune Checkpoint Inhibitors

The purpose of this research study is to see if the amount of vitamin D in ones blood makes it more or less likely to develop thyroid gland toxicity when being treated with immunotherapy that blocks the activity of proteins called programed death-1(PD-1) or programmed death ligand-1 (PD-L1). Immunotherapy is …

primary cancer
  • 19 Jul, 2021
  • 1 location