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Found 115 clinical trials
Synergetic B-cell Immunomodulation in SLE - 2nd Study. (SynBioSe-2)

-cell targeting by starting treatment with belimumab (anti-BAFF) followed by rituximab(anti-CD20) in lupus nephritis patients.

elisa
pericarditis
baff
vasculitis
azathioprine
  • 28 views
  • 27 Apr, 2022
  • 4 locations
ALlogeneic Cardiosphere-derived Stem Cells (CDCs) for Pulmonary Hypertension therApy

Pulmonary Arterial Hypertension or PAH is a progressive condition for which there is no cure. Even with substantial pharmacologic advances in the modern treatment era, survival still remains unacceptably poor, as reported in large PAH registries. Preclinical studies suggest that the administration of allogeneic CDCs have the potential to reduce …

  • 100 views
  • 25 Mar, 2021
  • 1 location
Study of Ravulizumab in Proliferative Lupus Nephritis (LN) or Immunoglobulin A Nephropathy (IgAN) (SANCTUARY)

The objectives of this study are to evaluate the safety and efficacy of ravulizumab administered by intravenous (IV) infusion compared to placebo and demonstrate proof-of-concept of the efficacy of terminal complement inhibition in participants with LN (LN Cohort) or IgAN (IgAN Cohort).

lupus
angiotensin
nephritis
proteinuria
immunoglobulin a
  • 5 views
  • 22 Jul, 2022
  • 68 locations
Phase 3 Study of Anifrolumab in Adult Patients With Active Proliferative Lupus Nephritis (IRIS)

The purpose of this study is to evaluate the efficacy and safety of IV antifrolumab in adult patients with Active Proliferative Lupus Nephritis

anifrolumab
chronic kidney disease
nephritis
  • 7 views
  • 11 Jul, 2022
  • 18 locations
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis (POSTERITY)

than 18 with biopsy-confirmed proliferative lupus nephritis (LN).

diphenhydramine
nephritis
proteinuria
mammogram
mycophenolate
  • 0 views
  • 10 Jul, 2022
  • 18 locations
Study of Safety, Efficacy and Tolerability of Secukinumab Versus Placebo, in Combination With SoC Therapy, in Patients With Active Lupus Nephritis (SELUNE)

active lupus nephritis (ISN/RPS Class III or IV, with or without co-existing class V features).

mammogram
urinary sediment
nephritis
glomerular filtration rate
  • 426 views
  • 24 Jul, 2022
  • 161 locations
A Study To Evaluate The Efficacy And Safety Of Obinutuzumab In Patients With ISN/RPS 2003 Class III Or IV Lupus Nephritis (REGENCY)

) class III or IV lupus nephritis (LN) when added on to standard-of-care therapy consisting of mycophenolate mofetil (MMF) and corticosteroids.

diphenhydramine
nephritis
kidney biopsy
corticosteroids
mammogram
  • 8 views
  • 10 Jul, 2022
  • 100 locations
Safety, Efficacy and Tolerability of Ianalumab Versus Placebo, Combination With SoC Therapy, in Participants With Active Lupus Nephritis (SIRIUS-LN)

This trial will evaluate efficacy, safety, and tolerability of subcutaneous (s.c.) ianalumab given every 4 weeks (q4w) or every 12 weeks (q12w) compared to placebo, in combination with SoC, in adult participants with active LN

nephritis
rheumatism
systemic lupus erythematosus
induction therapy
glomerulonephritis
  • 0 views
  • 10 Aug, 2022
  • 15 locations
Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases (EPPIK)

To evaluate the safety, efficacy and tolerability of sparsentan oral suspension and assess changes in proteinuria after once-daily dosing over the 108-week treatment period.

total protein
kidney biopsy
proteinuria
corticosteroids
mammogram
  • 0 views
  • 08 Aug, 2022
  • 24 locations
Atrasentan in Patients With Proteinuric Glomerular Diseases (AFFINITY)

The AFFINITY Study is a phase 2, open-label, basket study to evaluate the efficacy and safety of atrasentan in patients with proteinuric glomerular disease who are at risk of progressive loss of renal function.

type 2 diabetes mellitus
sglt2
total protein
corticosteroids
diabetes
  • 31 views
  • 17 Jun, 2022
  • 36 locations