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Found 111 clinical trials
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Rituximab plus Belimumab for Lupus Nephritis (CALIBRATE Study)

Rituximab plus Belimumab for Lupus Nephritis (CALIBRATE Study)

  • 926 views
  • 25 Mar, 2021
  • 12 locations
Synergetic B-cell Immunomodulation in SLE - 2nd Study.

-cell targeting by starting treatment with belimumab (anti-BAFF) followed by rituximab(anti-CD20) in lupus nephritis patients.

mycophenolate
myositis
rituximab
azathioprine
belimumab
  • 10 views
  • 07 Mar, 2021
  • 4 locations
ALlogeneic Cardiosphere-derived Stem Cells (CDCs) for Pulmonary Hypertension therApy

Pulmonary Arterial Hypertension or PAH is a progressive condition for which there is no cure. Even with substantial pharmacologic advances in the modern treatment era, survival still remains unacceptably poor, as reported in large PAH registries. Preclinical studies suggest that the administration of allogeneic CDCs have the potential to reduce …

  • 96 views
  • 25 Mar, 2021
  • 1 location
A Study of Guselkumab in Participants With Active Lupus Nephritis

The purpose of this study is to evaluate the efficacy of guselkumab in participants with active lupus nephritis (LN).

antinuclear antibody
kidney biopsy
mycophenolate
mammogram
nephritis
  • 0 views
  • 01 Aug, 2021
  • 69 locations
Study of Ravulizumab in Proliferative Lupus Nephritis (LN) or Immunoglobulin A Nephropathy (IgAN)

The objectives of this study are to evaluate the safety and efficacy of ravulizumab administered by intravenous (IV) infusion compared to placebo and demonstrate proof-of-concept of the efficacy of terminal complement inhibition in participants with LN (LN Cohort) or IgAN (IgAN Cohort).

immunosuppression
lupus
immunoglobulin a
nephritis
proteinuria
  • 0 views
  • 08 Jul, 2021
  • 30 locations
Safety Pharmacokinetics and Preliminary Efficacy Study of CFZ533 in Patients With Lupus Nephritis.

with moderately active lupus nephritis.

body mass index
systemic lupus erythematosus
antinuclear antibody
histological diagnosis
azathioprine
  • 124 views
  • 31 Jul, 2021
  • 26 locations
A Study of KZR-616 in Patients With SLE With and Without Lupus Nephritis

This is a Phase 1b/2, multi-center study in which patients will receive KZR-616, administered as a subcutaneous (SC) injection weekly for 13 weeks (Phase 1b) or 24 weeks (Phase 2).

kidney biopsy
systemic lupus erythematosus
body mass index
corticosteroids
leflunomide
  • 261 views
  • 10 May, 2021
  • 39 locations
Study of Safety Efficacy and Tolerability of Secukinumab Versus Placebo in Combination With SoC Therapy in Patients With Active Lupus Nephritis

active lupus nephritis (ISN/RPS Class III or IV, with or without co-existing class V features).

urinary sediment
mammogram
nephritis
glomerular filtration rate
  • 37 views
  • 30 Jul, 2021
  • 123 locations
Study of Lademirsen (SAR339375) in Patients With Alport Syndrome

Primary Objectives: To assess the efficacy of lademirsen (SAR339375) in reducing the decline in renal function To assess the safety and tolerability of lademirsen (SAR339375) in subjects with Alport syndrome Secondary Objectives: To assess plasma pharmacokinetic (PK) parameters of the parent compound and its metabolites To assess the potential formation …

  • 485 views
  • 01 Aug, 2021
  • 52 locations
Efficacy Safety and PK/PD of MOR202 in Anti-PLA2R + Membranous Nephropathy (aMN) (NewPLACE)

This 2-arm, multi-center, open-label, parallel-group phase II trial will assess the efficacy, safety and pharmacokinetics/pharmacodynamics of the human antibody MOR202 in subjects with anti-PLA2R antibody-positive membranous nephropathy indicated for immunosuppressive therapy

kidney biopsy
fibrosis
enzyme inhibitor
proteinuria
nephropathy
  • 0 views
  • 12 Jun, 2021
  • 16 locations