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Found 127 clinical trials
A Study to Understand Effectiveness and Safety of ABP 938 Compared to Aflibercept (Eylea ) in Patients Suffering With Neovascular Age-related Macular Degeneration [Neovascular (Wet) AMD]

The purpose of this study is to compare the efficacy and safety of ABP 938 versus Aflibercept (Eylea) in the treatment of neovascular age-related macular degeneration. Subjects will be randomized in a masked 1:1 ratio to receive 2 mg (0.05 mL) of either ABP 938 (Treatment Group or aflibercept (Treatment …

  • 28 Sep, 2021
  • 226 locations
An Extension Study Assessing the Efficacy and Safety of Brolucizumab in a Treat-to-Control Regimen in Patients With Neovascular Age-related Macular Degeneration Who Have Completed the CRTH258A2303 (TALON) Study

The purpose of this extension study is to evaluate the efficacy and safety of brolucizumab used in a Treat-to-Control-regimen for treatment of patients with neovascular age-related macular degeneration who have completed the CRTH258A2303 (TALON) study. The main objective is to assess brolucizumab's potential for long durability up to 20 weeks. …

  • 17 Jul, 2021
  • 49 locations
Efficacy and Safety of the Aflibercept FYB203 Biosimilar in Comparison to Eylea in Patients With Neovascular Age-Related Macular Degeneration

This is a randomized, double-masked, multicenter study to evaluate the efficacy and safety of FYB203 compared to Eylea in patients with neovascular age related macular degeneration.

age-related macular degeneration
  • 16 Aug, 2021
  • 53 locations
A Study to Comparing SCD411 and Eylea in Subjects With Wet Age-related Macular Degeneration (AMD)

Age-related macular degeneration (AMD) is a leading cause of vision loss in adults. Abnormal blood vessels grow under the macula at the back of the eye, and also leak blood and fluid, which damages and scars the macula, affecting vision. The current standard of care for patients with neovascular (exudative …

  • 27 Jan, 2021
  • 76 locations
Quality-Assured Follow-up of Quiescent Neovascular Age -Related maculaR dEgeneration by Non-medical Practitioners

This is a prospective, randomised, multi-site clinical trial testing the non-inferiority of community optometry follow-up of participants with QnAMD over 12 months

macular degeneration
optical coherence tomography
  • 27 Sep, 2021
  • 1 location
Neovascularization Embolisation for Knee Osteoarthritis.(NEO)

In this double blind randomized sham controlled study the investigators want to establish the efficacy of transcatheter arterial embolization of neovessels for patients with symptomatic mild to moderate knee osteoarthritis after 4 months compared to a sham-embolization.

conservative management
knee pain
  • 12 Feb, 2021
  • 1 location
Episcleral Brachytherapy for the Treatment of Wet AMD

This is a prospective, multi-site, safety and feasibility study of the SalutarisMD SMD-DA system for retrobulbar minimally invasive episcleral brachytherapy device in patients receiving and not responding to anti-VEGF therapy for nAMD. The trial will be open label and non-randomized. The study intervention is a one-time intervention and requires no …

  • 04 Apr, 2021
  • 2 locations
Intravitreal Adalimumab in Refractory Diabetic Retinopathy Choroidal Neovascularization or Uveitis: A Pilot Study

Direct intravitreal administration of medication is the preferred method of treatment for uveitis and retinal vascular disorders. The eye is a self contained organ relatively isolated from the systemic circulation by the tight blood retinal barrier. Effective intraocular drug levels can be achieved with a much smaller amount of medication …

corrected visual acuity
diabetic retinopathy
  • 07 Nov, 2020
  • 1 location
KDR2-2 Suspension Eyedrop in the Treatment of Neovascular Glaucoma (KDR-NVG) Trial

/per day/eye, in a QID fashion, 7 days (those without complications can continue to 28 days). The anti-neovascular effect of KDR2-2 on iris neovascularization would be evaluated at day 1, day 7, day 14

intraocular pressure
corrected visual acuity
  • 16 Sep, 2021
  • 1 location
Comparative Study With Photodynamic Therapy And Triamcinolone Versus Photodynamic Therapy Triamcinolone And Ranibizumab In Patients With Subfoveal Choroidal Neovascularization

The purpose of this study is to compare the efficacy of photodynamic therapy with verteporfin (PDT) and IVTA vs triple therapy (TT) in patients with subfoveal choroidal neovascularization

  • 07 Nov, 2020
  • 1 location