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Found 662 clinical trials
Neoadjuvant Treatment Modalities in Esophageal Cancer

Esophageal cancer is the most prevalent cancer globally with poor survival outcome. The prognosis with surgery alone is poor, accounting for 30-40% of overall survival at 5 year. Either neoadjuvant chemotherapy (nCT) or chemoradiotherapy (nCRT) has been shown as efficatious therapy to improve patients outcomes in esophageal or esophagogastric junction …

  • 0 views
  • 06 Apr, 2021
  • 1 location
Capnographic Monitoring in Gastrointestinal Endoscopy for Elderly Patients (CapnoGI)

Hypoxia is the most common adverse event in gastrointestinal endoscopes sedated with propofol and sufentanil, especially in elderly people. The aim of this randomized study was to determine whether intervention based on additional capnographic monitoring reduces the incidence of hypoxia in gastrointestinal endoscopes procedures for elderly patients.

Accepts healthy volunteers
propofol
endoscopy
  • 0 views
  • 05 Apr, 2022
  • 3 locations
Nasal Mask Kit in Gastrointestinal Endoscopy (NASO)

Hypoxia is the most common adverse event in gastrointestinal endoscopes sedated with propofol. The nasal mask oxygen kit has good sealing to ensure an adequate oxygen supply and is convenient and economical.The aim of this randomized study was to determine whether the nasal mask oxygen kit reduces the incidence of …

KIT
colonoscopy
Accepts healthy volunteers
propofol
endoscopy
  • 0 views
  • 07 Oct, 2022
  • 1 location
Study Assessing The "Best of" Radiotherapy vs the "Best of" Surgery in Patients With Oropharyngeal Carcinoma (Best Of)

conventional transoral techniques. On the other hand, patients with head and neck cancer treated with IMRT experienced significant improvements in cause specific survival (CSS) compared with patients treated

oropharyngeal squamous cell carcinoma
neck dissection
platelet count
robotic surgery
cancer
  • 8 views
  • 04 Oct, 2022
  • 29 locations
Phase 1 Study of CK-301 (Cosibelimab) as a Single Agent in Subjects With Advanced Cancers

CK-301 (cosibelimab) is a fully human monoclonal antibody of IgG1 subtype that directly binds to Programmed Death-Ligand 1 (PD-L1) and blocks its interactions with the Programmed Death-1 (PD-1) and B7.1 receptors. The primary objectives of this study are to assess the safety, tolerability and efficacy of CK-301 when administered intravenously …

stage iv nsclc
lymphoma
metastatic merkel cell carcinoma
cancer chemotherapy
merkel cell carcinoma
  • 2181 views
  • 10 Mar, 2022
  • 26 locations
Stereotactic Body Radiotherapy in Patients With Rare Oligometastatic Cancers (OligoRARE) (OligoRARE)

This is a randomized open-label multicentre Phase III superiority study of the effect of adding SBRT to the standard of care treatment on overall survival in patients with rare oligometastatic cancers. Patients will be randomized in a 1:1 ratio between current standard of care treatment vs. standard of care treatment …

brain metastases
metastasis
systemic therapy
  • 0 views
  • 26 May, 2022
  • 7 locations
Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery (GASVERT)

This is a single-center prospective clinical trial to evaluate non-inferiority of indocyanine green guided sentinel lymph node biopsy compared with the gold standard Technecium99 guided sentinel lymph node biopsy in patients with cancers and subjected to surgery. The diagnostic performance and the tolerance of indocyanine green (ICG) to the radio-isotope …

cancer surgery
probe
sentinel node
indocyanine green
mammogram
  • 34 views
  • 27 Apr, 2022
  • 1 location
An Open-Label, Multicenter, Global Phase 2 Basket Study of Entrectinib for the Treatment of Patients With Locally Advanced or Metastatic Solid Tumors That Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements (STARTRK-2)

This is an open-label, multicenter, global Phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1/2/3, ROS1, or ALK gene fusion. Patients will be assigned to different baskets according to tumor type and gene fusion.

solid tumor
lymphoma
gene fusion
cancer chemotherapy
cancer treatment
  • 16 views
  • 25 Oct, 2022
  • 9 locations
A Phase 1/2 Study of BMS-986340 as Monotherapy and in Combination With Nivolumab in Participants With Advanced Solid Tumors

The purpose of this study is to assess the safety, tolerability, and recommended dose(s) of BMS-986340 as monotherapy and in combination with nivolumab in participants with advanced solid tumors. This study is a first-in-human (FIH) study of BMS-986340 in participants with advanced solid tumors.

measurable disease
nivolumab
adenocarcinoma
cancer
lung carcinoma
  • 0 views
  • 19 Oct, 2022
  • 13 locations
Onco-primary Care Networking to Support TEAM-based Care (ONE TEAM)

The proposed ONE TEAM Study is an 18-month, cluster randomized controlled trial. This study will use a sequential multiple assignment randomized trial (SMART) design with a second randomization for the intervention group using a dynamic treatment regimen approach. The investigators propose to randomize 800 adults with newly-diagnosed selected cancers treated …

cancer surgery
cancer
primary cancer
hypertension
type 2 diabetes mellitus
  • 0 views
  • 09 Jun, 2022
  • 1 location