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Found 19 clinical trials
Inflammatory Response In Schizophrenia

schizophrenia, or whether this is a secondary phenomenon of no pathophysiological significance. The investigators therefore plan to test the effect of a monoclonal antibody (natalizumab) on psychotic symptoms

  • 0 views
  • 19 Feb, 2021
  • 1 location
Autologous Stem Cell Transplant for Crohn's Disease

agents (natalizumab, Vedolizumab) If patients meet entry criteria will undergo a baseline endoscopy, colonoscopy and MR or CT enterography. If documentation of active mucosal disease patients will then

bowel resection
discomfort
inflammatory bowel disease
infliximab
stem cell transplantation
  • 66 views
  • 25 Jan, 2021
  • 1 location
Decision Making in Multiple Sclerosis Care Under Uncertainty

The main objectives of this study are: i) To determine patient-level, physician-level and health system factors influencing therapeutic decisions in multiple sclerosis (MS) care by applying conjoint discrete experiments. ii) To determine the prevalence of therapeutic inertia among participating neurologists. iii) To compare clinical judgement vs. a qualitative or quantitative …

disease or disorder
fatigue
  • 7 views
  • 23 Jan, 2021
  • 1 location
Deficient T Regulatory Cell (Treg) Function in Patients With Relapsing Remitting Multiple Sclerosis

The purpose of this research is to find out how the T regulatory (Treg) cells control autoimmune response in multiple sclerosis. We will identify Treg molecular markers and changes in function in patients with relapse remitting multiple sclerosis (RRMS). We plan to study T regulatory immune cells in the blood …

  • 0 views
  • 28 Apr, 2021
  • 1 location
Evaluating the Efficacy and Safety of Transitioning Patients From Natalizumab to Ocrelizumab

The primary objective of this study is to assess the efficacy of Ocrelizumab (OCR) in Relapsing Multiple Sclerosis patients who have been previously treated with natalizumab (NTZ) by evaluating

relapsing multiple sclerosis
ocrelizumab
natalizumab
  • 62 views
  • 23 Jan, 2021
  • 5 locations
Comparing the Antibody Response to COVID-19 Vaccination in Multiple Sclerosis Patients Treated With Ocrelizumab or Natalizumab

The primary goal of this study is to determine if subjects currently receiving treatment with ocrelizumab or natalizumab produce antibodies to the SARS-CoV-2 spike protein receptor binding

  • 0 views
  • 26 Apr, 2021
  • 1 location
Study of Tysabri in Early Relapsing Remitting Multiple Sclerosis Participants

The purpose of this study is to evaluate the impact of an early treatment with Natalizumab on the management of the progressive nature of Relapsing Remitting Multiple Sclerosis (RRMS).

  • 0 views
  • 12 Apr, 2021
  • 18 locations
The Safety Assessment of Vedolizumab During Pregnancy in IBD Patient

The safety assessment of Vedolizumab during pregnancy in IBD patients. The primary objective of this study is: To quantify incidence of major structural birth defects and other birth outcomes in infants born to women with UC/CD with exposure to Entyvio compared to women with exposure to other biological agents or …

vedolizumab
  • 0 views
  • 22 Jan, 2021
  • 1 location
5-HT7 Receptor Implication in Inflammatory Mechanisms in Multiple Sclerosis

Multiple Sclerosis is a chronic autoimmune disease associated with inflammatory response harmful for the Central Nervous System. Immunological imbalance is involved with Th1 and Th17 cells in correlation with a disturbance of regulators mechanisms as Treg cells. Despite years of research, the mechanisms involved remain unclear. Serotonin (5-HT) seems to …

nervous
natalizumab
disease or disorder
myelopathies
neurological disorder
  • 0 views
  • 25 Jan, 2021
  • 1 location