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Found 5 clinical trials
Methylnaltrexone vs Naloxegol in the Treatment of Opioid-Induced Constipation

The purpose of this study is to compare the efficacy of subcutaneous versus oral mu-opioid receptor antagonist therapy in opioid induced constipation that is refractory to other bowel regimens.

  • 30 views
  • 10 Apr, 2022
  • 1 location
Naloxegol and Opioid-induced Constipation

This is a double-blind, randomized, placebo-controlled trial to examine the effectiveness of adding one 25mg dose of naloxegol to the cardiac surgery pre-operative regimen.

naloxegol
opioid-induced constipation
opioid
  • 20 views
  • 10 May, 2022
  • 1 location
The NIPA Study Naloxegol Administration to Prevent Opioids Induced Gastrointestinal Motility Disturbance in Brain Injured PAtients (NIPA)

also reduce the complications of feed intolerance and thus reduce morbidity and mortality in ICU. Naloxegol is a polyethylene glycol derivative of naloxol, which is a derivative of naloxone and

mechanical ventilation
cancer
  • 0 views
  • 13 Apr, 2022
  • 3 locations
Naloxegol Health Outcome Post Authorisation Safety Study

This post-authorization observational safety study (PASS) monitors clinically important identified and potential risks within a cohort of patients treated with naloxegol, including the

syncope
bowel perforation
laxative
naloxegol
hypertension
  • 0 views
  • 26 Jan, 2022
  • 3 locations
Risk of Major Adverse Cardiovascular Events for Naldemedine and Other Medications for Opioid Induced Constipation in Adults With Chronic Non-Cancer Pain

The research objective is to characterize the risk of a major adverse cardiovascular event (MACE) among new users of naldemedine versus new users of lubiprostone and new users of naloxegol as

analgesics
naldemedine
lubiprostone
cancer pain
naloxegol
  • 6 views
  • 10 Mar, 2022
  • 1 location