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Found 34 clinical trials
Intratympanic Administration of N-acetylcysteine for Protection of Cisplatin-induced Ototoxicity

This is a monocentric, randomized, controlled, open label phase IV superiority trial. After signing the informed consent form and upon the confirmation of the patient eligibility, patients will be randomized 1:1 to the experimental arm (NAC + Cisplatin) or the standard arm (Cisplatin). The primary objective of this trial is …

  • 0 views
  • 19 Feb, 2021
  • 1 location
N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use (NAC_CUD-TUD)

-use. N-acetylcysteine (NAC), an FDA-approved medication and over-the-counter supplement, has shown promise in animal studies and randomized controlled trials (RCTs) in reducing tobacco and cannabis

Accepts healthy volunteers
smoking cessation therapy
behavioral therapy
smoke tobacco
behavior therapy
  • 0 views
  • 17 Jun, 2022
  • 1 location
Assessment of N-Acetylcysteine as Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (NAC ME/CFS)

Chronic fatigue syndrome/myalgic encephalomyelitis (ME/CFS) is an unexplained multisymptom/multisystem disorder for which there are currently no validated treatments. The present exploratory clinical trial aims to advance our understand of the mechanisms of in situ GSH synthesis control through assessment of the response of brain GSH and plasma markers of oxidative …

fatigue
encephalomyelitis
  • 128 views
  • 08 Jul, 2022
  • 1 location
Evaluating the Hypothesized Mechanism of Action of N-acetylcysteine for Bipolar Disorder

This research study evaluates the effects of anFDA-approved medication NAC in individuals with Bipolar Disorder. Participants in the study will will be assigned to two medication conditions and will take both NAC and a matched placebo. The order in which they take each medication will be random. Study medication will …

brain imaging
lithium
divalproex sodium
mania
lamotrigine
  • 0 views
  • 24 Jul, 2022
  • 1 location
Efficacy of N-acetylcysteine on the Craving Symptoms of Abstinent Hospitalized Patients With Cocaine Addiction

rewarding feeling, which drives them to consume when they encounter them. N-acetylcysteine (NAC) has been used for a long time, mainly as mucolytic. It has also been used as a glutathione

addiction
addicted to cocaine
drug abuse
cocaine abuse
dopamine
  • 32 views
  • 26 Jul, 2022
  • 1 location
Targeting the Neurobiology of Restricted and Repetitive Behaviors in Children With Autism Using N-acetylcysteine

The goal of this study is to target the neurobiology of restricted and repetitive behaviors in children with autism spectrum disorder using N-acetylcysteine (NAC), a well-tolerated nutritional

  • 0 views
  • 26 Mar, 2022
  • 1 location
A Study of N-Acetylcysteine (N-AC)in People Receiving CAR T-cell Therapy for Lymphoma

The purpose of this study is to test the safety of N-AC when given in combination with Yescarta to people with lymphoma. This study will test different doses of N-AC to find the highest dose that causes few or mild side effects in participants.

lymphoma
  • 0 views
  • 21 Mar, 2022
  • 1 location
Correction of Neonatal Glutathione by N-acetylcysteine in Pregnant Women at Risk of Premature Birth (GSH MAP)

propose an early intervention that consists in an antenatal maternal supplementation with N-acetylcysteine (NAC), the acetylated precursor of both cysteine and glutathione, a key physiological antioxidant

nitric oxide
prematurity
premature labor
necrotizing enterocolitis
bronchopulmonary dysplasia
  • 25 views
  • 12 Feb, 2022
  • 1 location
The ACTS Trial: N-acetylcysteine (NAC) and Night-splinting as a Non-operative Treatment for Carpal Tunnel Syndrome

the investigators will examine whether there is any benefit to using oral N-acetylcysteine (NAC) as an adjunctive treatment for mild to moderate CTS in addition to a standard 8-week trial of night

nerve compression
numbness
nerve conduction
nerve conduction study
conservative management
  • 0 views
  • 19 Aug, 2021
  • 1 location
Study of N-acetylcysteine in the Treatment of Patients With the m.3243A>G Mutation and Low Brain Glutathione Levels

N-Acetylcysteine (NAC), an anti-oxidant, will be studied to investigate the effects on brain glutathione levels, cognitive skills, motor skills, and quality of life. A group of 18

  • 0 views
  • 08 Jun, 2022
  • 1 location