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Found 37 clinical trials
N-Acetylcysteine for Youth Cannabis Use Disorder

This is a 12-week randomized, placebo-controlled trial of N-acetylcysteine for cannabis use disorder (CUD) in youth (N=192). Participants will be randomized to double-blind NAC or PBO, yielding

  • 26 views
  • 15 Feb, 2022
  • 1 location
Intratympanic N-Acetylcysteine for Prevention of Cisplatin-induced Ototoxicity.

Although many intratympanic agents have been attempted, N-Acetylcysteine (NAC) appears to be the most promising and is a powerful, commonly used anti-oxidant. The goal of this prospective phase

  • 3 views
  • 28 Feb, 2022
  • 1 location
Pilon Fracture With Intra-articular Injection of N-Acetylcysteine (Pilon NAC)

of N-acetylcysteine (NAC) after an intra-articular knee fracture and its effect on the cartilage cell viability. Their study demonstrated that chondrocyte cell viability after an injection of NAC

  • 0 views
  • 22 Aug, 2021
  • 1 location
Glutathione, Oxidative Stress and Mitochondrial Function in COVID-19

amino-acids glycine and cysteine (provided as N-acetylcysteine) improves GSH deficiency and mitochondrial function, and lowers oxidative stress, inflammation, and endothelial dysfunction. The

  • 1 views
  • 25 Mar, 2022
  • 1 location
N-Acetylcysteine Protection Against Radiation Induced Cellular Damage

different response to IR results from inherited variants in genes involved in DNA damage repair. N-acetylcysteine (NAC) is an aminoacid that can directly neutralize free radicals and increase antioxidant

  • 0 views
  • 15 Feb, 2021
  • 1 location
N-Acetylcysteine for Adolescent Alcohol Use Disorder

This is a 8-week randomized, placebo-controlled trial testing the effects of N-acetylcysteine (NAC), on a platform of weekly evidence-based brief alcohol intervention for 120 adolescents with

n-acetylcysteine
  • 1 views
  • 28 Feb, 2022
  • 1 location
N-ACetylcysteine to Reduce Infection and Mortality for Alcoholic Hepatitis

mortality in patients treated with N-acetylcysteine combined with prednisolone when compared to prednisolone alone. The current study seeks to reveal whether the mechanism by which NAC reduces

serum bilirubin level
n acetylcysteine
prednisolone
n-acetylcysteine
  • 1 views
  • 16 Nov, 2021
  • 1 location
N-acetylcysteine for the Treatment of Cannabis Dependence: Working Mechanisms

This study investigates the effects of repeated NAC administration on glutamate concentrations in the anterior cingulate cortex (ACC), on neurocognitive functioning, and on neuro-inflammatory parameters in adult cannabis-dependent individuals.

Accepts healthy volunteers
n-acetylcysteine
  • 15 views
  • 23 Feb, 2022
  • 1 location
Treatment of Systemic Lupus Erythematosus (SLE) With N-acetylcysteine (NAC)

Systemic lupus erythematosus (SLE) is a chronic inflammatory disease which often has debilitating and potentially life-threatening consequences. The cause of SLE is unknown and current therapies lack specificity and carry significant side-effects. We previously discovered the depletion of glutathione in lymphocytes of patients with SLE and associated this metabolic change …

Accepts healthy volunteers
  • 0 views
  • 28 Jun, 2022
  • 1 location
Assessment of N-Acetylcysteine as Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Chronic fatigue syndrome/myalgic encephalomyelitis (ME/CFS) is an unexplained multisymptom/multisystem disorder for which there are currently no validated treatments. The present exploratory clinical trial aims to advance our understand of the mechanisms of in situ GSH synthesis control through assessment of the response of brain GSH and plasma markers of oxidative …

encephalomyelitis
fatigue
  • 117 views
  • 18 Jun, 2021
  • 1 location