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Found 7 clinical trials
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Spearhead 1 Study in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma

This is a study to investigate the efficacy and safety of ADP-A2M4 in HLA-A*02 eligible and MAGE-A4 positive subjects with metastatic or inoperable (advanced) Synovial Sarcoma (Cohort 1 and Cohort 2) or MRCLS (Cohort 1) .

  • 28 views
  • 26 Nov, 2021
  • 39 locations
None
Pilot Immunotherapy Study With Letetresgene Autoleucel (Lete-cel GSK3377794)T-cells Specific in NY-ESO-1/ LAGE-1a-positive Advanced Non-small Cell Lung Cancer (NSCLC) Either Alone or in Combination With Pembrolizumab

This trial will evaluate safety and efficacy of letetresgene autoleucel (GSK3377794) with or without pembrolizumab in participants with non-small cell lung cancer.

metastasis
targeted therapy
primary cancer
pd-l1
ROS1
  • 113 views
  • 10 Oct, 2021
  • 31 locations
None
Trabectedin Plus Radiotherapy in Soft Tissue Sarcoma Patients

unresectable or not oncologically recommended metastasectomy of limited to lung metastases soft tissue sarcoma. Cohort B: Patients with locally advanced resectable Myxoid Liposarcoma. Cohort C: Patients

undifferentiated pleomorphic sarcoma
liposarcoma
leiomyosarcoma
malignant peripheral nerve sheath tumor
fibrosarcoma
  • 25 views
  • 24 Jan, 2021
  • 21 locations
None
Itacitinib in Treating Patients With Refractory Metastatic/Advanced Sarcomas

This pilot phase I trial studies how well itacitinib works in treating patients with sarcomas that do not respond to treatment (refractory) and have spread to other parts of the body (advanced/metastatic). Itacitinib may cause changes in the immune system and the body's immune response to cancer, which may stop …

  • 10 views
  • 09 Jun, 2021
  • 1 location
None
Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgery

This phase II trial studies the side effects of talimogene laherparepvec and radiation therapy and to see how well they work in treating patients with newly diagnosed soft tissue sarcoma that can be removed by surgery. Biological therapies, such as talimogene laherparepvec, use substances made from living organisms that may …

undifferentiated pleomorphic sarcoma
liposarcoma
neutrophil count
tumor cells
soft tissue sarcoma
  • 28 views
  • 08 Dec, 2021
  • 10 locations
None
International Prospective Registry on Local Treatment Approaches in MLS

To prospectively study commonly used local treatment approaches in Myxoid Liposarcoma (MLS)

  • 0 views
  • 18 Aug, 2021
  • 1 location
None
Natural History and Biospecimen Acquisition for Children and Adults With Rare Solid Tumors

peripheral nerve sheath tumor Malignant triton tumor Medullary thyroid cancer Mixed acinar adenocarcinoma Mixed acinar neuroendocrine carcinoma Myxoid

solid tumor
Accepts healthy volunteers
cns tumor
cancer
  • 0 views
  • 08 Dec, 2021
  • 1 location