Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 66 clinical trials
Sodium Thiosulfate for Treatment of Calcinosis Associated With Juvenile and Adult Dermatomyositis

Background Dermatomyositis (DM) and juvenile dermatomyositis (JDM) cause inflammation in the muscles. People with DM and JDM can develop calcium deposits in places they should not, known as calcinosis. Calcinosis can be painful and cause disabilities and other problems. Researchers want to learn more about calcinosis to find treatments for …

igiv
calcium
blood tests
kidney ultrasound
urine tests
  • 190 views
  • 22 Jul, 2022
  • 1 location
Assessment of Safety and Acute Effects of a Lower-limb Powered Dermoskeleton in Patients With Neuromuscular Disorders (Exo-KGO1)

The aims of the current study are as follow: i) Evaluate the safety, usability, and acute efficiency of a programmable ambulation exoskeleton (KeeogoTM Dermoskeleton System, B-Temia Inc., Quebec, Canada) in patients with neuromuscular disorders, ii) Elaborate recommendations regarding usability criteria for safe and efficient use the device in patients with …

Accepts healthy volunteers
myopathy
respiratory assessment
  • 0 views
  • 24 Apr, 2022
  • 1 location
Assessment of Safety and Acute Effects of a Knee-hip Powered Soft Exoskeleton in Patients With Neuromuscular Disorders (Exo-NMD1)

The aims of the current study are as follow: i) Evaluate the safety, usability, and acute efficiency of a powered knee-hip dermoskeleton (MyoSuit, MyoSwiss, Zurich, Switzerland) in patients with neuromuscular disorders, ii) Elaborate recommendations regarding usability criteria for safe and efficient use the device in patients with neuromuscular disorders (e.g. …

Accepts healthy volunteers
myopathy
respiratory assessment
  • 0 views
  • 25 Mar, 2022
  • 1 location
Exercise Capacity of Patients With Dermatomyosis

Dermatomyositis (DM) patients experience muscle weakness and low aerobic capacities, which are associated with poor health status and increased mortality. The origin of this muscle impairment remains unknown. The investigators hypothesize that mitochondria functioning is impaired in DM muscle and links with exercise capacities.

weakness
creatine kinase
muscle biopsy
polymyositis
dermatomyositis
  • 0 views
  • 19 Sep, 2021
  • 1 location
Subcutaneous Injection of Sodium Thiosulfate for Ectopic Calcifications or Ossifications. A Pilot Study (ITS-PILOT)

Ectopic soft tissue calcifications or ossifications can complicate the course of numerous diseases; most of them are rare or very rare. Even if the clinical, radiological and pathological presentation of ectopic calcifications and ossifications are different, the same hypotheses are discussed considering their hypothetical pathophysiology. Indeed, high calcium phosphate product, …

calcium
progressive systemic sclerosis
parathyroid hormone
computerized tomography
dermatomyositis
  • 13 views
  • 24 Mar, 2022
  • 3 locations
Single Escalating Dose Pilot Trial of Canakinumab (ILARIS®) in Duchenne Muscular Dystrophy

serum biomarkers in a sample of young boys with DMD who are most likely to have high levels of muscle inflammation. Steroid naive DMD subjects aged greater than or equal to 2 years old to less than 6

muscular dystrophy
duchenne muscular dystrophy
glucocorticoids
  • 21 views
  • 12 Mar, 2022
  • 1 location
Cyclophosphamide and Azathioprine vs Tacrolimus in Antisynthetase Syndrome-related Interstitial Lung Disease

"Antisynthetase syndrome (ASS) is one of the most severe inflammatory myopathy (IM), due to pulmonary involvement (interstitial lung disease, ILD). Until now, the most commonly used

  • 1 views
  • 15 Feb, 2021
  • 1 location
Impacts of Mitochondrial-targeted Antioxidant on Peripheral Artery Disease Patients

systemic and skeletal muscle inflammation due to the impaired oxygen transfer capacity of these blood vessels. This attenuated oxygen transfer capacity causes hypoxic conditions in the skeletal muscle and

cardiovascular disease
peripheral arterial diseases
intermittent claudication
diabetes
arteriopathy
  • 5 views
  • 01 Jul, 2022
  • 1 location
Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer

This phase Ib trial studies the side effects of nivolumab and to see how well it works in treating patients with autoimmune disorders and cancer that has spread to other places in the body or cannot removed by surgery. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's …

lymphoma
solid tumor
lung cancer
nervous
tumor cells
  • 995 views
  • 28 Jul, 2022
  • 33 locations
Immunosuppressant Combined With Pirfenidone in CTD-ILD

A prospective cohort study was used to observe the efficacy and safety of different immunosuppressive agents with/wo pirfenidone on CTD-ILD patients in Qilu Hospital of Shandong University for 36 months.The main research endpoints are lung function, patient dyspnea score, 6-minute walking distance, imaging indicators, primary disease activity, adverse reactions, etc.

immunosuppressive
rheumatism
pirfenidone
progressive systemic sclerosis
dyspnea
  • 2 views
  • 24 Jun, 2021
  • 1 location