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Found 64 clinical trials
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Single Escalating Dose Pilot Trial of Canakinumab (ILARIS ) in Duchenne Muscular Dystrophy

serum biomarkers in a sample of young boys with DMD who are most likely to have high levels of muscle inflammation. Steroid naive DMD subjects aged greater than or equal to 2 years old to less than 6

glucocorticoids
muscular dystrophy
  • 21 views
  • 04 Mar, 2021
  • 1 location
None
Cyclophosphamide and Azathioprine vs Tacrolimus in Antisynthetase Syndrome-related Interstitial Lung Disease

"Antisynthetase syndrome (ASS) is one of the most severe inflammatory myopathy (IM), due to pulmonary involvement (interstitial lung disease, ILD). Until now, the most commonly used

  • 0 views
  • 15 Feb, 2021
  • 1 location
None
Impacts of Mitochondrial-targeted Antioxidant on Peripheral Artery Disease Patients

systemic and skeletal muscle inflammation due to the impaired oxygen transfer capacity of these blood vessels. This attenuated oxygen transfer capacity causes hypoxic conditions in the skeletal muscle and

diabetes
cardiovascular disease
intermittent claudication
peripheral arterial diseases
treadmill test
  • 5 views
  • 01 Sep, 2021
  • 1 location
None
Lumbar Spine Muscle Degeneration Inhibits Rehabilitation-Induced Muscle Recovery

results in a state of muscle inflammation, atrophy, fibrosis, and muscle degeneration that is not responsive to exercise. The Investigators will identify which patients respond to exercise by examining

back pain
atrophy
discectomy
low back pain
  • 269 views
  • 11 Apr, 2021
  • 1 location
None
COVID-19 Vaccination in Rheumatic Disease Patients

The research is being done to study the immune responses to COVID-19 vaccination in patients with rheumatic diseases.

  • 0 views
  • 18 Apr, 2021
  • 1 location
None
Nivolumab in Treating Patients With Autoimmune Disorders and Advanced Metastatic or Unresectable Cancer

This phase Ib trial studies the side effects of nivolumab and to see how well it works in treating patients with autoimmune disorders and cancer that has spread to other places in the body or cannot removed by surgery. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's …

interleukin-2
follicle stimulating hormone
computed tomography
absolute neutrophil count
nervous
  • 855 views
  • 26 Nov, 2021
  • 33 locations
None
Immunosuppressant Combined With Pirfenidone in CTD-ILD

A prospective cohort study was used to observe the efficacy and safety of different immunosuppressive agents with/wo pirfenidone on CTD-ILD patients in Qilu Hospital of Shandong University for 36 months.The main research endpoints are lung function, patient dyspnea score, 6-minute walking distance, imaging indicators, primary disease activity, adverse reactions, etc.

rheumatism
immunosuppressive
dyspnea
progressive systemic sclerosis
pirfenidone
  • 0 views
  • 24 Jun, 2021
  • 1 location
None
Role of Metformin on Muscle Health of Older Adults

Muscle atrophy and insulin resistance are common after bed rest in healthy older adults. Metformin treatment has been shown to improve insulin sensitivity and attenuate muscle loss in insulin resistance adults though the mechanisms are not fully known. Metformin used as a preventive strategy to maintain muscle and metabolic health …

insulin
Accepts healthy volunteers
bed rest
  • 1 views
  • 04 Oct, 2021
  • 1 location
None
Resistance Training Intervention to Improve Physical Function in Patients With Pancreatic Cancer Receiving Combination Chemotherapy or Have Undergone Surgery PancStrength Study

This clinical trial studies the safety of a real-time tele-exercise resistance training (training done using a tablet) in maintaining skeletal muscle, strength, physical function, and health-related quality of life in patients with pancreatic cancer who are receiving combination chemotherapy or have undergone surgery for the treatment of pancreatic cancer. Tele-exercise …

  • 0 views
  • 17 Apr, 2021
  • 1 location
None
Leflunomide for Musculoskeletal GVHD After Allogeneic Stem Cell Transplant

Graft versus host disease (GVHD) is a well-known complication of allogeneic transplant. In GVHD, the cells of the donor attack the patient's tissues and cause damage. It can affect any organ or system of the body. In a proportion of patients, it affects the joints and muscles. This is known …

  • 0 views
  • 28 Jun, 2021
  • 1 location