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Found 67 clinical trials
A Study of Nipocalimab in Participants With Active Idiopathic Inflammatory Myopathies (SPIREA)

The purpose of this study is to evaluate the efficacy and safety of Nipocalimab versus placebo in participants with active idiopathic inflammatory myopathies (IIM).

myopathy
prednisone
dermatomyositis
tacrolimus
  • 0 views
  • 25 Jul, 2022
  • 1 location
Inclusion Body Myositis Treatment With Celution Processed Adipose Derived Regenerative Cells

This is an open-label, single arm study evaluating the safety for patients with Inclusion Body Myositis. A total of 9 subjects will be enrolled in the study. Subjects will be randomized to Part

weakness
inclusion body myositis
  • 1 views
  • 25 May, 2022
  • 1 location
Novel PET Radioligands as Inflammatory Biomarkers in Rheumatoid Arthritis and Myositis

18 and older with rheumatoid arthritis or idiopathic inflammatory myopathy (IIM). Healthy volunteers enrolled in protocol 01-M-0254 or 17-M-0181 are also needed. Design

heart disease
anxiety
myositis
remission
celecoxib
  • 46 views
  • 10 Aug, 2022
  • 1 location
Exercise, Creatine and Coenzyme Q10 for Childhood Myositis

Children with JDM are weak and get tired because their muscles aren't able to work like healthy muscles. This can make it hard for them to do normal everyday things and can make them less happy about their lives compared to children without the disease. There are two nutritional supplements …

  • 0 views
  • 16 May, 2022
  • 1 location
Search for Diagnostic and Prognostic Biomarkers in Systemic Sclerosis and Inflammatory Myopathies

Systemic sclerosis and inflammatory myopathies, which sometimes combine (scleromyositis), have shared pathophysiological elements. In both diseases, many cell subtypes are involved in damage to

myopathy
raynaud's phenomenon
muscle biopsy
raynaud's syndrome
scleroderma
  • 0 views
  • 23 Dec, 2021
  • 1 location
A Phase 1 Study of ABC008 in Adult Patients With Inclusion Body Myositis (IBM)

An open-label, ascending dose study for adult patients with inclusion body myositis (IBM).

inclusion body myositis
  • 2 views
  • 05 Mar, 2022
  • 4 locations
Clinical Study of MMF in Treatment of IIM-ILD and Its Effect on Peripheral Blood Treg Cells

Interstitial lung disease (ILD) is a common pulmonary manifestation of idiopathic inflammatory myopathy (IIM). The overall 5-year mortality is 50%. The prognosis is poor and the treatment is

pulmonary fibrosis
forced vital capacity
fibrosis
lupus
cyclophosphamide
  • 0 views
  • 30 Nov, 2021
  • 1 location
Tolerability and Safety of Nintedanib in Myositis Associated Interstitial Lung Disease: a Pilot Study

There is likely a role for using anti-fibrotic medications in patients with myositis-associated interstitial lung disease (MA-ILD) to slow down disease progression, especially in patients who

forced vital capacity
interstitial lung disease
azathioprine
dermatomyositis
bronchiectasis
  • 0 views
  • 01 May, 2022
  • 1 location
Phase III Trial of Sirolimus in IBM

The hypothesis is that Sirolimus, (Rapamycin (R)) which is currently used in organ transplantation and works by blocking the activity of T effector cells but preserving T regulatory cells, as well as by inducing autophagy (protein degradation), will be effective in IBM to slow or stabilize disease progression, helping to …

immunosuppression
  • 0 views
  • 23 Jul, 2022
  • 3 locations
Sodium Thiosulfate for Treatment of Calcinosis Associated With Juvenile and Adult Dermatomyositis

Background Dermatomyositis (DM) and juvenile dermatomyositis (JDM) cause inflammation in the muscles. People with DM and JDM can develop calcium deposits in places they should not, known as calcinosis. Calcinosis can be painful and cause disabilities and other problems. Researchers want to learn more about calcinosis to find treatments for …

calcium
myositis
aldolase
dermatomyositis
juvenile dermatomyositis
  • 190 views
  • 22 Jul, 2022
  • 1 location