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Found 64 clinical trials
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Abatacept for the Treatment of Myositis-associated Interstitial Lung Disease

A randomized, controlled pilot trial to evaluate the efficacy and safety of subcutaneous Abatacept in treating interstitial lung disease associated with the anti-synthetase syndrome.

tumor necrosis factor
azathioprine
rituximab
pirfenidone
anakinra
  • 188 views
  • 18 Apr, 2021
  • 5 locations
None
Exercise Creatine and Coenzyme Q10 for Childhood Myositis

Children with JDM are weak and get tired because their muscles aren't able to work like healthy muscles. This can make it hard for them to do normal everyday things and can make them less happy about their lives compared to children without the disease. There are two nutritional supplements …

  • 0 views
  • 06 May, 2021
  • 1 location
None
A Phase 1 Study of ABC008 in Adult Patients With Inclusion Body Myositis (IBM)

An open-label, ascending dose study for adult patients with inclusion body myositis (IBM).

inclusion body myositis
  • 0 views
  • 06 Oct, 2021
  • 2 locations
None
Inclusion Body Myositis Treatment With Celution Processed Adipose Derived Regenerative Cells

This is an open-label, single arm study evaluating the safety for patients with Inclusion Body Myositis. A total of 9 subjects will be enrolled in the study. Subjects will be randomized to Part

inclusion body myositis
weakness
  • 0 views
  • 05 Dec, 2021
  • 1 location
None
Sodium Thiosulfate for Treatment of Calcinosis Associated With Juvenile and Adult Dermatomyositis

Background Dermatomyositis (DM) and juvenile dermatomyositis (JDM) cause inflammation in the muscles. People with DM and JDM can develop calcium deposits in places they should not, known as calcinosis. Calcinosis can be painful and cause disabilities and other problems. Researchers want to learn more about calcinosis to find treatments for …

myositis
diabetes
igiv
dermatomyositis
juvenile dermatomyositis
  • 76 views
  • 18 Nov, 2021
  • 1 location
None
Effects of High-intensity Interval Training (HIIT) in Recent Onset Polymyositis and Dermatomyositis

Polymyositis and dermatomyositis are rare inflammatory systemic conditions. Reduced muscle function is a cardinal symptom and lung involvement is very common. Knowledge of heart involvement in these patients is very limited, as is knowledge of exercise effects in recent onset, active disease. The aim of this project is to investigate …

cancer
dermatomyositis
depression
high-intensity interval training
strength training
  • 18 views
  • 22 Jan, 2021
  • 1 location
None
Phase 1 Study of ULSC in Patients With Polymyositis (PM) and Dermatomyositis (DM)

This study will investigate Umbilical Cord Lining Stem Cells (ULSC) as an investigational medicinal product and its use in patients with polymyositis (PM) or dermatomyositis (DM) to see if a single intravenous (IV) infusion of allogeneic umbilical cord lining stem cells (ULSC) safe, tolerable, and feasible to administer.

dermatomyositis
polymyositis
  • 0 views
  • 27 Nov, 2021
  • 1 location
None
Clinical Study of MMF in Treatment of IIM-ILD and Its Effect on Peripheral Blood Treg Cells

Interstitial lung disease (ILD) is a common pulmonary manifestation of idiopathic inflammatory myopathy (IIM). The overall 5-year mortality is 50%. The prognosis is poor and the treatment is

cyclophosphamide
ciclosporin
azathioprine
fibrosis
forced vital capacity
  • 0 views
  • 30 Nov, 2021
  • 1 location
None
Exercise Capacity of Patients With Dermatomyosis

Dermatomyositis (DM) patients experience muscle weakness and low aerobic capacities, which are associated with poor health status and increased mortality. The origin of this muscle impairment remains unknown. The investigators hypothesize that mitochondria functioning is impaired in DM muscle and links with exercise capacities.

dermatomyositis
muscle biopsy
polymyositis
myopathy
weakness
  • 0 views
  • 19 Sep, 2021
  • 1 location
None
Subcutaneous Injection of Sodium Thiosulfate for Ectopic Calcifications or Ossifications. A Pilot Study

Ectopic soft tissue calcifications or ossifications can complicate the course of numerous diseases; most of them are rare or very rare. Even if the clinical, radiological and pathological presentation of ectopic calcifications and ossifications are different, the same hypotheses are discussed considering their hypothetical pathophysiology. Indeed, high calcium phosphate product, …

dermatomyositis
computerized tomography
parathyroid hormone
progressive systemic sclerosis
calcium
  • 12 views
  • 25 Jan, 2021
  • 5 locations