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Found 58 clinical trials
JAK 1/2 Inhibitor, Baricitinib, in the Treatment of Adult IIM

This study aims to investigate the clinical efficacy of baricitinib in patients with adult idiopathic inflammatory myositis (IIM). Half of the patients enrolled onto the study will receive 24

prednisone
polymyositis
a 12
dermatomyositis
MRI
  • 0 views
  • 15 Dec, 2021
  • 1 location
Saracatinib Trial TO Prevent FOP

This is a phase 2 study, designed as a European multicentre 6-month double blind random-ized controlled trial (RCT) of AZD0530 versus matched placebo, followed by a 12 month trial comparing open-label extended AZD0530 treatment with historical control data. Study population: Male and female adult patients aged 18 years and older …

  • 0 views
  • 25 Jan, 2021
  • 3 locations
Study to Assess the Efficacy and Safety of 2 Dosage Regimens of Oral IPN60130 for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP).

Fibrodysplasia Ossificans Progressiva (FOP) is a rare, severely disabling disease characterized by the presence of bone in soft tissue where bone normally does not exist, known as Heterotopic Ossification (HO). It is often associated with painful, recurrent episodes of soft tissue swelling (flare-ups) that lead to abnormal stiffening and immobility …

  • 0 views
  • 22 Dec, 2021
  • 1 location
Lipid-lowering Agents in Patients With Dermatomyositis and Polymyositis

The use of lipid lowering agents in patients with idiopathic inflammatory myopathies is controversial. Therefore, the aim of the present study is to assess clinically and laboratory the impact

polymyositis
  • 0 views
  • 27 Jan, 2021
  • 1 location
Monotherapy IVIG Gamunex-C for HMG-CoA Reductase Auto-Antibody Positive Necrotizing Myopathy Treatment (The MIGHT Trial)

This is a phase 2, pilot, randomized, placebo-controlled trial of Gamunex-C IVIG as mono-therapy for HMGCoA reductase auto-antibody positive (HMGCR) necrotizing myopathy. The trial will test the feasibility and initial efficacy of Gamunex-C IVIG mono-therapy in HMGCR necrotizing myopathy.

  • 0 views
  • 24 Sep, 2021
  • 1 location
Intraorbital Injection Versus Oral Steroid in Anterior Idiopathic Orbital Inflammation

A multicenter randomised double-arm clinical trial, to compare safety and efficacy of oral versus intralesional injection of steroid in a group of patients suffering from idiopathic orbital inflammation is designed. Outcome measures include number of recurrences, duration of remission, and side effects.

  • 6 views
  • 08 Jul, 2021
  • 1 location
A Study to Evaluate the Efficacy Safety and Pharmacokinetics of IgPro20 in Adults With Dermatomyositis (DM)

This is a phase 3, multicenter, randomized, placebo-controlled, double-blind study of IgPro20 (subcutaneous Ig) treatment in adult subjects with dermatomyositis (DM). The primary objective of this study is to assess the efficacy of IgPro20 subcutaneous (SC) doses in comparison to placebo in adult subjects with DM, as measured by responder …

a 10
rheumatism
corticosteroids
rash
dermatomyositis
  • 35 views
  • 14 Jun, 2021
  • 103 locations
A Study In Adults With Moderate To Severe Dermatomyositis

A Study looking at Investigational drug and Placebo administered to adult Patients with moderate to severe Dermatomyositis

corticosteroids
experimental drug
rash
dermatomyositis
  • 260 views
  • 20 Jan, 2022
  • 50 locations
Novel PET Radioligands as Inflammatory Biomarkers in Rheumatoid Arthritis and Myositis

18 and older with rheumatoid arthritis or idiopathic inflammatory myopathy (IIM). Healthy volunteers enrolled in protocol 01-M-0254 or 17-M-0181 are also needed. Design

myositis
MRI
Accepts healthy volunteers
celecoxib
anxiety
  • 36 views
  • 10 Oct, 2021
  • 1 location
Abatacept for the Treatment of Myositis-associated Interstitial Lung Disease

A randomized, controlled pilot trial to evaluate the efficacy and safety of subcutaneous Abatacept in treating interstitial lung disease associated with the anti-synthetase syndrome.

methotrexate
tumor necrosis factor
azathioprine
leflunomide
immunosuppressants
  • 188 views
  • 18 Apr, 2021
  • 5 locations