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Found 489 clinical trials
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Prospective Natural History Study of Patients With Myotubular Myopathy and Other CentroNuclear Myopathies

This is the 2 years extension of the prospective and longitudinal study of the natural history and functional status of patients with myotubular myopathy and other centronuclear (CNM) sponsored

  • 2 views
  • 27 Jan, 2021
  • 14 locations
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Early Phase Human Drug Trial to Investigate Dynamin 101 (DYN101) in Patients 16 Years With Centronuclear Myopathies

There are no available treatments aside from supportive care for patients with Centronuclear myopathy (CNM). This trial will assess the safety, tolerability, PK and PD/preliminary efficacy of a

  • 2 views
  • 24 Sep, 2021
  • 11 locations
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Tamoxifen Therapy for Myotubular Myopathy

This is a phase 1 / 2, randomized, double-blinded, single cross-over study, with a washout period between treatment regimens, to test the efficacy and safety of tamoxifen therapy to improve motor and respiratory function in males with XLMTM.

  • 0 views
  • 04 Jul, 2021
  • 4 locations
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The Effects of Exercise Versus Inactivity on People With Mitochondrial Muscle Disease

Mitochondrial myopathies include various inherited diseases that are caused by damage to the mitochondria, energy-producing structures that fuel the body's processes. The main symptoms

  • 96 views
  • 07 Nov, 2020
  • 1 location
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MABs Therapy m.3243A>G Mutation Carriers

combat the myopathy and exercise intolerance which affect >50% of heteroplasmic mtDNA mutation carriers. Myogenic stem cells called mesoangioblasts (MABs), are currently the only myogenic precursors

  • 0 views
  • 07 Oct, 2021
  • 1 location
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Monotherapy IVIG Gamunex-C for HMG-CoA Reductase Auto-Antibody Positive Necrotizing Myopathy Treatment (The MIGHT Trial)

This is a phase 2, pilot, randomized, placebo-controlled trial of Gamunex-C IVIG as mono-therapy for HMGCoA reductase auto-antibody positive (HMGCR) necrotizing myopathy. The trial will test the

  • 0 views
  • 24 Sep, 2021
  • 1 location
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Identification of New Markers of Atrial Myopathy in Patients With Embolic Stroke of Undetermined Source (ESUS) From MRI 4D Data

Atrial myopathy is considered to be the underlying cause of a large proportion of embolic strokes of undetermined source. However, the definition of this atrial condition is not well delineated

  • 0 views
  • 26 Mar, 2021
  • 3 locations
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Lipid-lowering Agents in Patients With Dermatomyositis and Polymyositis

The use of lipid lowering agents in patients with idiopathic inflammatory myopathies is controversial. Therefore, the aim of the present study is to assess clinically and laboratory the impact

polymyositis
  • 0 views
  • 27 Jan, 2021
  • 1 location
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Quantification Analysis and Simulation of Facial Mimics Movements

testing, in order to evaluate a facial muscular disorder. This assessment remains subjective because the investigators are deducing from surfacing cutaneous deformations the movement quality of the

  • 0 views
  • 30 Aug, 2021
  • 1 location
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PReventing EXtubation FAILure Related to Cough

frequently used for patients presenting a chronic neuro-muscular disease affecting their ability to spontaneously clear their airways from an inappropriate bronchial overload. However, the interest of such

  • 0 views
  • 02 Jun, 2021
  • 1 location