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Found 475 clinical trials
Prospective Natural History Study of Patients With Myotubular Myopathy and Other CentroNuclear Myopathies (NatHis-CNM)

This is the 2 years extension of the prospective and longitudinal study of the natural history and functional status of patients with myotubular myopathy and other centronuclear (CNM) sponsored

  • 25 Feb, 2022
  • 10 locations
STREAM Trial - Statins in Multimorbid Older Adults Without Cardiovascular Disease (STREAM)

Statins are among the most widely used drugs. While they were found to be effective for primary and secondary prevention of cardiovascular disease (CVD) in middle-aged subjects, their benefits for primary prevention in older adults (aged ≥70 years) without CVD are uncertain, particularly for those with multimorbidity. The aim of …

  • 24 Mar, 2022
Adult Autoimmune Myopathies (MAIA) (MAIA)

This study corresponds to a monocentric prospective cohort of adult patients presenting a suspicion of idiopathic inflammatory myopathy. It will allows the constitution of an organized

  • 04 Jun, 2022
  • 1 location
Tamoxifen Therapy for Myotubular Myopathy

This is a phase 1 / 2, randomized, double-blinded, single cross-over study, with a washout period between treatment regimens, to test the efficacy and safety of tamoxifen therapy to improve motor and respiratory function in males with XLMTM.

  • 04 Jul, 2021
  • 4 locations
Clinical Characteristics and Mechanism Research of Inhibitors of Janus Kinase in the Treatment of Idiopathic Inflammatory Myopathies

This study aims to explore the clinical characteristics and mechanism research of inhibitors of janus kinase in the treatment of idiopathic inflammatory myopathies

immunosuppressive agents
  • 14 Jun, 2022
  • 1 location
Home Based Personalized Training and Video Consultation in Mitochondrial Myopathies: Study of Efficacy and Tolerance. (TELE-MIT)

Positive effect of physical activity on health arouses a strong interest at international level and is developped within the scope of national programs. Recommandations exist but must be designed for patients with functional limitations of activities. Patients with mitochondrial diseases have exercice intolerance with an increase of muscular weakness and …

  • 24 Jul, 2022
  • 1 location
An Open Label, Long Term Safety Study of REN001 in Primary Mitochondrial Myopathy Patients (Stride Ahead)

This is a long-term safety and tolerability study. REN001 is administered once daily to subjects with PMM who have previously completed Study REN001-201 or participated in Study REN001-101 and withdrew from that study due to the COVID-19 pandemic.

  • 22 Apr, 2022
  • 3 locations
A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate the Efficacy of ManNAc in Subjects With GNE Myopathy (MAGiNE)

GNE myopathy is a rare genetic muscle disease characterized by progressive muscle atrophy and weakness. The disease is caused by mutations in the gene that encodes the enzyme that initiates and

  • 20 Sep, 2022
  • 6 locations
MABs Therapy m.3243A>G Mutation Carriers

combat the myopathy and exercise intolerance which affect >50% of heteroplasmic mtDNA mutation carriers. Myogenic stem cells called mesoangioblasts (MABs), are currently the only myogenic precursors

  • 07 Oct, 2021
  • 1 location
High-definition Surface Electromyography Markers for the Diagnosis of Sarcopenia (CHRONOS-SARC)

Sarcopenia is a progressive and generalised skeletal muscle disorder involving the accelerated loss of muscle mass and function that is associated with increased adverse outcomes including falls

Accepts healthy volunteers
  • 16 Jun, 2022
  • 1 location