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Found 42 clinical trials
Myocardial Fibrosis, Function and Aging (MARVEL)

In normal ageing, the impact of myocardial fibrosis on myocardial function is unclear as diastolic function is reported to change according to age. The objective is to explore the relationship

Accepts healthy volunteers
  • 53 views
  • 13 Mar, 2022
  • 1 location
Impact of Preoperative Myocardial Fibrosis Related to Mitral Valve Prolapse on Postoperative Left Ventricular Remodeling (IMPARED)

Mitral Regurgitation. Very little data concerning the impact of preoperative RMRF on mitral valve surgery outcomes is available, and the impact of myocardial fibrosis on the postoperative left ventricle

mitral valve repair
prolapse
MRI
left ventricular remodeling
  • 0 views
  • 04 Oct, 2022
  • 1 location
Effect of Antifibrotic Therapy on Regression of Myocardial Fibrosis After Transcatheter Aortic Valve Implantation (TAVI) in Aortic Stenosis Patients With High Fibrotic Burden (Reduce-MFA)

The aim of the study is to evaluate the effect of antifibrotic therapy on regression of myocardial fibrosis after TAVI in patients with baseline high fibrotic burden. Therefore, patients will be

  • 0 views
  • 12 Jul, 2022
  • 1 location
STretch and Myocardial Characterization in Arrythmogenic Mitral Valve Prolapse-2 (STAMP-2)

, detection of myocardial fibrosis and a mitral ring disjunction among patients with MVP were associated with the occurrence of severe ventricular arrhythmia. The investigators hypothesize that

  • 0 views
  • 04 Oct, 2022
  • 1 location
Phenotype Identification Based on Multimodal MRI Analysis of Patients With Bronchial Obstructive Diseases (PIMABOD)

, pulmonary vessels, pulmonary parenchyma, right and left ventricular function, myocardial fibrosis and pulmonary arterial pressure. Such imaging will also offer the advantage of being non-irradiating

  • 0 views
  • 04 Jun, 2022
  • 6 locations
Prediction of Reverse Remodeling and Outcome in Patients With Severe Secondary Mitral Valve Regurgitation Undergoing Transcatheter Edge-to-edge Mitral Valve Repair

The investigators' hypothesis is that CMR tissue characterization and myocardial function analysis acquired by CMR feature tracking technique predict reverse remodeling in patients with severe secondary mitral regurgitation (MR) undergoing transcatheter mitral edge-to-edge repair.

  • 0 views
  • 05 Sep, 2021
  • 1 location
Caloric Restriction and Exercise for Protection From Anthracycline Toxic Effects (CREATE)

Doxorubicin and epirubicin are part of the class of chemotherapy agents called anthracyclines that are commonly used to treat breast cancer. Although these treatments work well against the tumor, they are known to cause damage to the heart muscle, resulting in diminished heart function that can be permanent, and may …

breast cancer staging
breast cancer
cancer
anthracyclines
doxorubicin
  • 143 views
  • 04 Oct, 2022
  • 1 location
Cardiac Magnetic Resonance GUIDEd Management of Mild-moderate Left Ventricular Systolic Dysfunction.

, ICM) and replacement myocardial fibrosis (seen in Non-Ischemic Cardiomyopathy, NICM). Methods/Design: A multi-centre randomised controlled trial in which 428 patients with mild-moderate left

sudden cardiac death
angiotensin
left ventricular systolic dysfunction
ace inhibitor
systolic dysfunction
  • 84 views
  • 26 Jan, 2021
  • 20 locations
Losartan for Diffuse Myocardial Fibrosis in Sickle Cell Disease

This study is a pilot, phase II, open-label study of the angiotensin II receptor blocker, losartan, in patients with Sickle Cell Disease (SCD) 6 years or older for 12 months. The investigators will enroll 24 patients with SCD over the course of 1 year with a goal to complete all …

Accepts healthy volunteers
  • 0 views
  • 26 Jan, 2022
  • 1 location
Ultrasonic Markers for Myocardial Fibrosis and Prognosis in Aortic Stenosis

develop increased amounts of myocardial fibrosis. This fibrosis is associated with the patients' prognosis. Fibrosis can be evaluated with magnetic resonance imaging (MRI), which unfortunately is quite

myocardial fibrosis
Accepts healthy volunteers
fibrosis
blood test
MRI
  • 1 views
  • 11 Oct, 2022
  • 1 location