Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 179 clinical trials
Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression

The standard Johns Hopkins' regimen will be used in study subjects, with the use of donor peripheral blood stem cells, rather than marrow. Clinical outcomes will be defined while focusing efforts on immune reconstitution focusing on immune checkpoint regulators after a related haploidentical stem cell transplant.

lymphoid leukemia
fludarabine
total body irradiation
carbon monoxide
acute leukemia
  • 168 views
  • 24 Jan, 2021
Irradiation-based Myeloablative Conditioning Followed by Treg/Tcon Immunotherapy in HSCT

To evaluate if hyper-fractionated TBI or TMLI followed by Treg/Tcon adoptive immunotherapy improve cGvHD/disease free survival after allogeneic HSCT in patients affected by high-risk acute leukemias or other hematologic malignancy where HSCT is indicated.

lymphoid leukemia
myeloproliferative syndromes
acute leukemia
leukemia
chronic myeloid leukemia
  • 6 views
  • 23 Jan, 2021
  • 1 location
Cord Blood Transplant in Children and Young Adults With Blood Cancers and Non-malignant Disorders

This is a single-arm study to investigate 1-year treatment related mortality (TRM) in patients with life threatening non-malignant and malignant hematologic disorders who do not have a matched related donor for allogeneic transplantation.

  • 0 views
  • 28 Jan, 2021
  • 1 location
5-Azacitidine and Decitabine Epigenetic Therapy for Myeloid Malignancies

Another term for myelodysplastic syndrome is bone marrow failure. The bone marrow is where components of blood such as red cells, platelets and white cells are made. In bone marrow failure, the ability for bone marrow to make these cells is decreased. In myelodysplastic syndrome, this decreased bone marrow function …

cytopenia
direct bilirubin
refractory cytopenia with multilineage dysplasia
myeloproliferative disorder
azacitidine
  • 0 views
  • 26 Jan, 2021
  • 1 location
Efficiency of Neuromuscular Bite vs Physiotherapy in TMD Patients

Temporomandibular joint dysfunction (TMD) therapy remains an open challenge for modern dentistry. Usually physiotherapy is considered a reliable approach to treatment of TMD patients. Moreover, neuromuscular bites (orthotic) are able to reduce signs and symptoms of TMD. To our knowledge, no specific trials have been designed for the evaluation of …

temporomandibular joint syndrome
ache
  • 6 views
  • 22 Jan, 2021
  • 1 location
Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Chemotherapy

This phase I trial studies the side effects and best dose of edetate calcium disodium or succimer in treating patients with acute myeloid leukemia or myelodysplastic syndrome undergoing chemotherapy. Edetate calcium disodium or succimer may help to lower the level of metals found in the bone marrow and blood and …

blast crisis
myeloid leukemia
calcium
succimer
refractory acute myeloid leukemia (aml)
  • 10 views
  • 03 Feb, 2021
  • 1 location
Allogeneic Hematopoietic Cell Transplantation From HLA-matched Donor After Flu-Mel-PTCy Versus Flu-Mel-ATG Reduced-intensity Conditioning

The present project aims at comparing two conditioning regimens (FM-PTCy vs FM-ATG). The hypothesis is that one or the two regimens will lead to a 2-year cGRFS rate improvement from 30% (the cGRFS rate with FM without ATG/PTCy) to 45% (Pick-a-winner phase 2 randomized study).

lymphoid leukemia
blast crisis
fludarabine
myeloproliferative syndromes
antithymocyte globulin
  • 0 views
  • 25 Jan, 2021
  • 9 locations
Chemotherapy Total Body Irradiation and Post-Transplant Cyclophosphamide in Reducing Rates of Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant

This phase II trial studies how well chemotherapy, total body irradiation, and post-transplant cyclophosphamide work in reducing rates of graft versus host disease in patients with hematologic malignancies undergoing a donor stem cell transplant. Drugs used in the chemotherapy, such as fludarabine phosphate and melphalan hydrochloride, work in different ways …

lymphoid leukemia
allogeneic hematopoietic stem cell transplant
blast crisis
white blood cell count
fludarabine
  • 45 views
  • 27 Jan, 2021
  • 1 location
MSC and HSC Coinfusion in Mismatched Minitransplants

The present project aims at evaluating the capacity of MSC to improve one-year overall survival of patients transplanted with HLA-mismatched PBSC from related or unrelated donors after non-myeloablative conditioning. Co-infusion of MSC has been shown to facilitate engraftment of hematopoietic stem cell (HSC) in an immunodeficient mouse model. In addition, …

blast crisis
fludarabine
tacrolimus
serum bilirubin level
hypertension
  • 100 views
  • 25 Jan, 2021
  • 11 locations
Triplex Vaccine in Preventing CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplantation

This phase II trial studies how well Triplex vaccine works in preventing cytomegalovirus (CMV) infection in patients undergoing a hematopoietic stem cell transplantation. CMV is a virus that may be carried for life and does not cause illness in most healthy individuals. However, in people whose immune systems are lowered …

lymphoid leukemia
lymphocytic leukemia
leukemia
human chorionic gonadotropin
modified vaccinia ankara
  • 4 views
  • 25 Jan, 2021
  • 1 location