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Found 191 clinical trials
CLL1-CD33 cCAR in Patients With Relapsed and/or Refractory High Risk Hematologic Malignancies

Phase I, interventional, single arm, open label, treatment study to evaluate the safety and tolerability of CLL1-CD33 cCAR in patients with relapsed and/or refractory, high risk hematologic malignancies.

immunosuppressant
myelodysplastic syndrome with excess blasts-2
corticosteroids
raeb ii
induction chemotherapy
  • 15 views
  • 27 May, 2021
  • 2 locations
Study of a Geriatric Assessment to Plan a Treatment Approach for Older People With Various Blood Disorders

, ,myelodysplastic syndromes, myeloproliferative neoplasms, or related blood disorders who are going to receive chemotherapy or another treatment to prepare the body for an allogeneic hematopoietic stem cell

leukemia
chronic myelomonocytic leukemia
transplant conditioning
chronic myeloid leukemia
myeloid leukemia
  • 0 views
  • 27 May, 2021
  • 7 locations
A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Hematopoietic Cell Transplantation

Myeloproliferative Neoplasms (MPN) who relapse after haploidentical hematopoietic cell transplantation (haplo-HCT). This study will also study CIML NK cell infusion combined with IL-2 in pediatric patients (12 years

prednisone
cyclophosphamide
myeloproliferative disorder
graft versus host disease
fludarabine
  • 4 views
  • 05 Aug, 2021
Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression

The standard Johns Hopkins' regimen will be used in study subjects, with the use of donor peripheral blood stem cells, rather than marrow. Clinical outcomes will be defined while focusing efforts on immune reconstitution focusing on immune checkpoint regulators after a related haploidentical stem cell transplant.

immune regulators
myelofibrosis
chronic lymphocytic leukemia
neutrophil count
acute leukemia
  • 168 views
  • 12 May, 2021
  • 1 location
Ivosidenib and Venetoclax With or Without Azacitidine in Treating Patients With IDH1 Mutated Hematologic Malignancies

This phase Ib/II trial studies the side effects and best dose of venetoclax and how well it works when given together with ivosidenib with or without azacitidine, in treating patients with IDH1-mutated hematologic malignancies. Venetoclax and ivosidenib may stop the growth of cancer cells by blocking some of the enzymes …

direct bilirubin
azacitidine
induction chemotherapy
hematologic malignancy
blast cells
  • 39 views
  • 09 Jul, 2021
  • 6 locations
Thrombosomes in Bleeding Thrombocytopenic Patients Study

This prospective, multicenter, randomized, open-label, Phase 2, parallel, dose ranging, multidose trial will enroll patients into 3 Thrombosomes dose groups and 1 control liquid stored platelets (LSP) group in order to evaluate, in a dose-escalation manner, the safety, and impact on bleeding, and the preliminary effect on coagulation measures of …

  • 0 views
  • 09 May, 2021
  • 3 locations
Irradiation-based Myeloablative Conditioning Followed by Treg/Tcon Immunotherapy in HSCT

To evaluate if hyper-fractionated TBI or TMLI followed by Treg/Tcon adoptive immunotherapy improve cGvHD/disease free survival after allogeneic HSCT in patients affected by high-risk acute leukemias or other hematologic malignancy where HSCT is indicated.

chronic lymphocytic leukemia
hematologic malignancy
lymphoid leukemia
remission
graft versus host disease
  • 6 views
  • 23 Jan, 2021
  • 1 location
Cord Blood Transplant in Children and Young Adults With Blood Cancers and Non-malignant Disorders

This is a single-arm study to investigate 1-year treatment related mortality (TRM) in patients with life threatening non-malignant and malignant hematologic disorders who do not have a matched related donor for allogeneic transplantation.

cyclosporine
myelofibrosis
consolidation chemotherapies
clofarabine
busulfan
  • 0 views
  • 19 May, 2021
  • 1 location
Effects of Prebiotics on Gut Microbiome in Patients Undergoing HSCT

The purpose of this study is to see whether hematopoietic stem cell transplant (HSCT) patients can consistently eat a diet rich in prebiotics. This type of diet may be helpful in maintaining diversity in the gastrointestinal (GI) system and therefore potentially decreasing risk of other GI problems.

  • 0 views
  • 31 Mar, 2021
  • 1 location
Allogeneic Hematopoietic Cell Transplantation From HLA-matched Donor After Flu-Mel-PTCy Versus Flu-Mel-ATG Reduced-intensity Conditioning

The present project aims at comparing two conditioning regimens (FM-PTCy vs FM-ATG). The hypothesis is that one or the two regimens will lead to a 2-year cGRFS rate improvement from 30% (the cGRFS rate with FM without ATG/PTCy) to 45% (Pick-a-winner phase 2 randomized study).

chronic lymphocytic leukemia
myelodysplastic syndromes
blast crisis
hematologic malignancy
melphalan
  • 0 views
  • 25 Jan, 2021
  • 9 locations