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Found 191 clinical trials
PLX51107 and Azacitidine in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome

This phase I trial studies the side effects and best dose of PLX51107 and how well it works with azacitidine in treating patients with acute myeloid leukemia or myelodysplastic syndrome. PLX51107 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used …

colony stimulating factor
cytotoxic agents
cytarabine
ejection fraction
myelodysplastic/myeloproliferative neoplasm
  • 0 views
  • 24 Jan, 2021
  • 1 location
A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Haploidentical Hematopoietic Cell Transplantation

Neoplasms (MPN.

myeloproliferative disorder
graft versus host disease
cyclophosphamide
prednisone
blast cells
  • 4 views
  • 01 Aug, 2021
A Phase 1 Trial of CD25/Treg-depleted DLI Plus Ipilimumab for Myeloid Disease Relapse After Matched-HCT

side effects are seen in patients with Acute Myeloid Leukemia (AML), Myelodysplastic Syndromes (MDS), Myeloproliferative Neoplasms (MPN), Chronic Myelomonocytic Leukemia (CMML), or Myelofibrosis (MF

myeloproliferative disorder
graft versus host disease
hemolysis
bone marrow procedure
myelomonocytic leukemia
  • 50 views
  • 30 Jun, 2021
Haplo Peripheral Blood Sct In GVHD Prevention

(MDS), myeloproliferative disorders (MPN), chronic myelomonocytic leukemic (CMML), chemosensitive hodgkin lymphoma (HL), or Non-Hodgkin lymphoma (NHL).who will have a blood stem cell transplantation

gilbert's syndrome
hodgkin's disease
bone marrow procedure
graft versus host disease
cyclophosphamide
  • 0 views
  • 25 Jan, 2021
Fractionated Gemtuzumab Ozogamicin in Treating Measurable Residual Disease in Patients With Acute Myeloid Leukemia High-Risk Myelodysplastic Syndrome or High-Risk Myeloproliferative Neoplasm

syndrome or high-risk myeloproliferative neoplasm. Gemtuzumab ozogamicin is a monoclonal antibody, called gemtuzumab, linked to a chemotherapy drug, called ozogamicin. Gemtuzumab is a form of targeted

gilbert's syndrome
tumor cells
residual tumor
gemtuzumab
gemtuzumab ozogamicin
  • 5 views
  • 27 May, 2021
  • 1 location
Azacitidine Venetoclax and Gilteritinib in Treating Patients With Recurrent/Refractory FLT3-Mutated Acute Myeloid Leukemia Chronic Myelomonocytic Leukemia or High-Risk Myelodysplastic Syndrome/Myeloproliferative Neoplasm

positive acute myeloid leukemia, chronic myelomonocytic leukemia, or high-risk myelodysplastic syndrome/myeloproliferative neoplasm that has come back (recurrent) or has not responded to treatment

  • 8 views
  • 09 Jul, 2021
  • 1 location
Azacitidine Venetoclax and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

This phase I/II trial studies the best dose of venetoclax when given together with azacitidine and pevonedistat and to see how well it works in treating patients with newly diagnosed acute myeloid leukemia. Drugs used in chemotherapy, such as azacitidine, work in different ways to stop the growth of cancer …

tumor cells
polycythemia
polycythemia vera
mds/mpn-u
chronic eosinophilic leukemia
  • 40 views
  • 18 Mar, 2021
  • 1 location
CPX-351 and Ivosidenib for the Treatment of IDH1 Mutated Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

This phase II trial investigates how well CPX-351 and ivosidenib work in treating patients with acute myeloid leukemia or high-risk myelodysplastic syndrome that has IDH1 mutation. The safety of this drug combination will also be studied. IDH1 is a type of genetic mutation (change). Chemotherapy drugs, such as CPX-351, work …

  • 0 views
  • 04 Apr, 2021
  • 1 location
Filgrastim Cladribine Cytarabine and Mitoxantrone With Sorafenib in Treating Patients With Newly-Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

This phase I/II trial studies the side effects and best dose of filgrastim (granulocyte colony-stimulating factor [G-CSF]), cladribine, cytarabine, and mitoxantrone, when given together with sorafenib and to see how well they work in treating patients with newly-diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome (likely to be more aggressive). …

gilbert's syndrome
colony stimulating factor
bone marrow procedure
cytarabine
ejection fraction
  • 78 views
  • 06 Jul, 2021
  • 1 location
Recombinant Human Interleukin-7 to Promote T-Cell Recovery After Cord Blood Transplant

myeloid leukemia, or myeloproliferative disease after a cord blood transplant. Umbilical cord blood is a source of blood-forming cells that can be used for transplant, also known as a graft. However

chronic myeloid leukemia
myeloproliferative disorder
graft versus host disease
granulocyte colony stimulating factor
colony stimulating factor
  • 0 views
  • 31 Jul, 2021