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Found 190 clinical trials
Is Clonal Hematopoiesis of Indeterminate Potential Associated With Unprovoked Pulmonary Embolism?

The clonal hematopoiesis of indetermined prognosis (CHIP) has been described as risk factor for juvenile atherosclerosis. Moreover, some of CHIP genes are responsible of myeloproliferative

thrombosis
clot
  • 0 views
  • 30 Jul, 2021
  • 1 location
Dual Vaccine Trial in Myeloproliferative Neoplasms

A phase I-II study in patients with mutated MPN by vaccinating with PD-L1 and Aginase1 peptides with Montanide ISA-51 as adjuvant, to monitor the immunological response to vaccination and

essential thrombocythemia
pd-l1 peptide
thrombocytosis
myeloproliferative disorder
polycythemia vera
  • 0 views
  • 23 Jan, 2021
  • 1 location
Remotely Administered Diet Intervention to Impact Symptom Burden in Myeloproliferative Neoplasm

Myeloproliferative Neoplasm (MPN) is a chronic blood cancer without cure. The major clinical issues in MPN are 1) an increased risk of blood clots 2) symptoms thought to be driven by chronic

  • 0 views
  • 18 Feb, 2021
  • 1 location
Aprepitant Versus Hydroxyzine in Persistent Aquagenic Pruritus for Patients With Myeloproliferative Neoplasms

Phase 3, randomized prospective study, double blind-double placebo, testing oral therapies APREPITANT versus HYDROXYZINE in patients followed for myeloproliferative neoplasms and suffering of

anagrelide
polycythemia vera
ruxolitinib
hydroxyurea
polycythemia
  • 0 views
  • 23 Jun, 2021
  • 13 locations
Intra-patient Dose Escalation Study to Investigate Safety and Feasibility of Vactosertib in Treating Anemic MPN Patients

patients with myeloproliferative neoplasms and it is thought that abnormal TGF signals cause many of the problems with blood cell formation in these diseases. The study design allows all patients to

anemia
hydroxyurea
myelodysplastic/myeloproliferative neoplasm
ruxolitinib
  • 0 views
  • 28 Jan, 2021
  • 1 location
Pilot Study for the Development of a Diagnostic Score to Differentiate Myeloproliferative Neoplasms.

Prospective study for the development of a non-invasive score for differentiating prefibrotic myelofibrosis from essential thrombocytosis and overt myelofibrosis.

  • 0 views
  • 23 Jan, 2021
  • 2 locations
Assessing Feasibility of Thromboprophylaxis With Apixaban in JAK2-positive Myeloproliferative Neoplasm Patients

Myeloproliferative neoplasms (MPNs) are blood disorders that occur when the body makes too many white or red blood cells, or platelets. This overproduction of blood cells in the bone marrow can

  • 0 views
  • 11 Mar, 2021
  • 1 location
Decitabine With Ruxolitinib or Fedratinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

myeloproliferative neoplasms (tumors). Drugs used in chemotherapy, such as decitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by

stem cell transplantation
myeloid leukemia
fedratinib
hydroxyurea
essential thrombocythemia
  • 7 views
  • 26 Feb, 2021
  • 1 location
Sotatercept in Treating Patients With Myeloproliferative Neoplasm-Associated Myelofibrosis or Anemia

This phase II trial studies the side effects of and how well sotatercept works in treating patients with myeloproliferative neoplasm-associated myelofibrosis or anemia. Sotatercept may stop the

conjugated bilirubin
vasectomy
myeloproliferative disorder
cancer
direct bilirubin
  • 1052 views
  • 24 Jan, 2021
  • 2 locations
Venetoclax Added to Fludarabine + Busulfan Prior to Transplant for AML MDS and MDS/MPN

/myeloproliferative neoplasm-unclassifiable (MDS/MPN-unclassifiable) and are planning to have an allogeneic hematopoietic stem cell transplant ("bone marrow transplant"). The goal of this research study is to (1

remission
myeloid leukemia
TP53
myelodysplasia
gilbert's syndrome
  • 31 views
  • 23 Jul, 2021
  • 1 location