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Found 189 clinical trials
IMG-7289 in Patients With Essential Thrombocythemia

This is a Phase 2b open label study of an orally administered LSD1 inhibitor, IMG-7289, in patients with essential thrombocythemia. This study investigates the following: The safety and tolerability of IMG-7289 The pharmacodynamic effect of IMG-7289

thrombocytosis
platelet count
interferon
thrombosis
  • 0 views
  • 06 Mar, 2021
  • 1 location
Hematology IMG-7289 LSD1 (Lysine-Specific Demethylase 1) Inhibitor Essential Thrombocythemia (ET) Ph 2

This is a single-center, open-label investigator-initiated trial evaluating the effects of IMG-7289 administered orally once daily in patients with essential thrombocythemia.

platelet count
myelofibrosis
neutrophil count
lysine
hydroxyurea
  • 0 views
  • 24 Jan, 2021
Hepcidin Mimetic in Patients With Polycythemia Vera

This is a Phase 2 study with an open-label dose escalation phase followed by a blinded withdrawal phase and an open label extension. The study is designed to monitor the PTG-300 safety profile and to obtain preliminary evidence of efficacy of PTG-300 for the treatment of phlebotomy-requiring polycythemia vera.

ruxolitinib
interferon
hydroxyurea
phlebotomy
  • 8 views
  • 26 Jan, 2021
  • 17 locations
Study of Stem Cell Transplant vs. Non-Transplant Therapies in High-Risk Myelofibrosis

The purpose of this research study is to see how effective hematopoietic stem cell transplantation (HCT) is compared to best available non-transplant therapies (BAT) in patients with high risk myelofibrosis. This will be done by asking participants to choose the treatment that they prefer to receive (HCT or BAT) and …

ruxolitinib
polycythemia
cancer
essential thrombocythemia
hydroxyurea
  • 0 views
  • 24 Feb, 2021
  • 6 locations
Tagraxofusp (SL-401) in Patients With CMML or MF

This multi-center, multi-arm trial is evaluating the safety and efficacy of tagraxofusp, a CD123-targeted therapy, in patients with either chronic myelomonocytic leukemia (CMML) or myelofibrosis (MF). There are two CMML cohorts, one enrolling patients with CMML (CMML-1 or CMML-2) who are refractory/resistant or intolerant to hypomethylating agents (HMA), hydroxyurea (HU), …

myelofibrosis
neutrophil count
platelet count
hydroxyurea
chronic myelomonocytic leukemia
  • 145 views
  • 24 Jan, 2021
  • 13 locations
Molecular Biology of Polycythemia and Thrombocytosis

Our study is designed to characterize the clinical picture and genetic pattern of Polycythemia and Thrombocytosis. The purpose of this project is to find a gene and its mutation that causes these disorders. When this is accomplished, new therapies to control and eventually cure the disorder can be designed.

  • 5 views
  • 26 Jan, 2021
  • 1 location
Decitabine Venetoclax and Ponatinib for the Treatment of Philadelphia Chromosome-Positive Acute Myeloid Leukemia or Myeloid Blast Phase Chronic Myelogenous Leukemia

To determine the efficacy of the regimen, as defined by the rate of complete remission (CR) or CR with incomplete count recovery (CRi)

serum lipase
chronic myeloid leukemia
remission
hemolysis
venetoclax
  • 0 views
  • 28 Mar, 2021
Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refractory Leukemias or Solid Tumors

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and efficacy of ponatinib in children aged 1 to < 18 years with advanced leukemias, lymphomas, and solid tumors.

cns tumor
chronic myeloid leukemia
KIT
lymphoma
blast crisis
  • 23 views
  • 26 Jan, 2021
  • 32 locations
Connect Myeloid Disease Registry

The purpose of the Connect Myeloid disease registry is to provide unique insights into treatment decisions and treatment patterns as they relate to clinical outcomes of patients with myeloid diseases in routine clinical practice. This disease registry will also evaluate molecular and cellular markers that may provide further prognostic classification …

myeloid leukemia
myelofibrosis
myelodysplastic syndromes
leukemia
bone marrow procedure
  • 2004 views
  • 10 Apr, 2021
  • 229 locations
Venetoclax Ponatinib and Dexamethasone in Participants With Philadelphia Chromosome or BCR-ABL Positive Relapsed or Refractory Acute Lymphoblastic Leukemia or Chronic Myelogenous Leukemia

This phase I/II trial studies the best dose of venetoclax when given together with ponatinib and dexamethasone and to see how well they work in treating participants with Philadelphia chromosome or BCR-ABL positive acute lymphoblastic leukemia or chronic myelogenous leukemia that has come back or does not respond to treatment. …

rituximab
serum lipase
chronic myeloid leukemia
hemolysis
tyrosine
  • 55 views
  • 25 Jan, 2021
  • 1 location