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Found 175 clinical trials
A Phase 1/1b Study Evaluating the Safety, Pharmacokinetics, and Preliminary Efficacy of LP-118 in Subjects With Relapsed or Refractory Hematological Malignancies

This is a Phase 1, multi-center, open-label study with a dose-escalation phase (Phase 1a) and a cohort expansion phase (Phase 1b), to evaluate the safety, tolerability, and PK profile of LP-118 under a once daily oral dosing schedule in up to 100 subjects.

leukemia
refractory multiple myeloma
white blood cells
chemotherapy regimen
chronic myeloid leukemia
  • 2 views
  • 20 Sep, 2022
  • 5 locations
Personalized NK Cell Therapy After Chemotherapy and Cord Blood Transplant in Treating Patients With Myelodysplastic Syndrome, Leukemia, Lymphoma or Multiple Myeloma

This phase II clinical trial studies how well personalized natural killer (NK) cell therapy works after chemotherapy and umbilical cord blood transplant in treating patients with myelodysplastic syndrome, leukemia, lymphoma or multiple myeloma. This clinical trial will test cord blood (CB) selection for human leukocyte antigen (HLA)-C1/x recipients based on …

blood transfusion
acute biphenotypic leukemia
rituximab
autologous hematopoietic stem cell transplant
chronic myeloid leukemia
  • 58 views
  • 05 Jul, 2022
  • 1 location
Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases

This is a treatment guideline for an unrelated umbilical cord blood transplant (UCBT) using a myeloablative preparative regimen for the treatment of hematological diseases, including, but not limited to acute leukemias. The myeloablative preparative regimen will consist of cyclophosphamide (CY), fludarabine (FLU) and fractionated total body irradiation (TBI).

imatinib
raeb
cyclosporine
chronic myeloid leukemia
chemotherapy regimen
  • 146 views
  • 25 Feb, 2022
  • 1 location
Constitution of a Biological Collection to Study the Pathophysiology in Noonan Syndrome (Noonan)

The present study will establish a collection of biological samples from Noonan patients to be used for research purposes only, with due respect for confidentiality.

  • 0 views
  • 23 Apr, 2022
  • 1 location
Transplantation of Umbilical Cord Blood for Patients With Hematological Diseases With Cyclophosphamide/Fludarabine/Total Body Irradiation or Cyclophosphamide/Fludarabine/Thiotepa/Total Body Irradiation Myeloablative Preparative Regimen

This phase II trial studies how well giving an umbilical cord blood transplant together with cyclophosphamide, fludarabine, and total-body irradiation (TBI) works in treating patients with hematologic disease. Giving chemotherapy, such as cyclophosphamide and fludarabine, and TBI before a donor umbilical cord blood transplant helps stop the growth of cancer …

carbon monoxide
imatinib
raeb
acute biphenotypic leukemia
cyclosporine
  • 129 views
  • 16 Sep, 2022
  • 1 location