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Found 178 clinical trials
Study of a Geriatric Assessment to Plan a Treatment Approach for Older People With Various Blood Disorders

This study will evaluate whether a geriatric assessment can lead to better treatment outcomes in older patients (age 60+) with myelodysplastic syndromes, myeloproliferative neoplasms, or related

  • 0 views
  • 03 Mar, 2021
  • 7 locations
Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression

The standard Johns Hopkins' regimen will be used in study subjects, with the use of donor peripheral blood stem cells, rather than marrow. Clinical outcomes will be defined while focusing efforts on immune reconstitution focusing on immune checkpoint regulators after a related haploidentical stem cell transplant.

myeloid leukemia
stem cell transplantation
fludarabine
waldenstrom's macroglobulinemia
immune regulators
  • 168 views
  • 24 Jan, 2021
Irradiation-based Myeloablative Conditioning Followed by Treg/Tcon Immunotherapy in HSCT

To evaluate if hyper-fractionated TBI or TMLI followed by Treg/Tcon adoptive immunotherapy improve cGvHD/disease free survival after allogeneic HSCT in patients affected by high-risk acute leukemias or other hematologic malignancy where HSCT is indicated.

myeloid leukemia
hematologic malignancy
graft versus host disease
stem cell transplantation
lymphoma
  • 6 views
  • 23 Jan, 2021
  • 1 location
Cord Blood Transplant in Children and Young Adults With Blood Cancers and Non-malignant Disorders

This is a single-arm study to investigate 1-year treatment related mortality (TRM) in patients with life threatening non-malignant and malignant hematologic disorders who do not have a matched related donor for allogeneic transplantation.

  • 0 views
  • 28 Jan, 2021
  • 1 location
Efficiency of Neuromuscular Bite vs Physiotherapy in TMD Patients

Temporomandibular joint dysfunction (TMD) therapy remains an open challenge for modern dentistry. Usually physiotherapy is considered a reliable approach to treatment of TMD patients. Moreover, neuromuscular bites (orthotic) are able to reduce signs and symptoms of TMD. To our knowledge, no specific trials have been designed for the evaluation of …

ache
temporomandibular joint syndrome
  • 6 views
  • 22 Jan, 2021
  • 1 location
5-Azacitidine and Decitabine Epigenetic Therapy for Myeloid Malignancies

Another term for myelodysplastic syndrome is bone marrow failure. The bone marrow is where components of blood such as red cells, platelets and white cells are made. In bone marrow failure, the ability for bone marrow to make these cells is decreased. In myelodysplastic syndrome, this decreased bone marrow function …

conjugated bilirubin
erythropoietin
azacitidine
chronic myelomonocytic leukemia
filgrastim
  • 0 views
  • 26 Jan, 2021
  • 1 location
Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Chemotherapy

This phase I trial studies the side effects and best dose of edetate calcium disodium or succimer in treating patients with acute myeloid leukemia or myelodysplastic syndrome undergoing chemotherapy. Edetate calcium disodium or succimer may help to lower the level of metals found in the bone marrow and blood and …

myelodysplastic/myeloproliferative neoplasm
myeloid leukemia
tubal ligation
blast crisis
calcium
  • 10 views
  • 03 Feb, 2021
  • 1 location
Allogeneic Hematopoietic Cell Transplantation From HLA-matched Donor After Flu-Mel-PTCy Versus Flu-Mel-ATG Reduced-intensity Conditioning

The present project aims at comparing two conditioning regimens (FM-PTCy vs FM-ATG). The hypothesis is that one or the two regimens will lead to a 2-year cGRFS rate improvement from 30% (the cGRFS rate with FM without ATG/PTCy) to 45% (Pick-a-winner phase 2 randomized study).

melphalan
myeloid leukemia
cell transplantation
leukapheresis
thymoglobulin
  • 0 views
  • 25 Jan, 2021
  • 9 locations
Chemotherapy Total Body Irradiation and Post-Transplant Cyclophosphamide in Reducing Rates of Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant

This phase II trial studies how well chemotherapy, total body irradiation, and post-transplant cyclophosphamide work in reducing rates of graft versus host disease in patients with hematologic malignancies undergoing a donor stem cell transplant. Drugs used in the chemotherapy, such as fludarabine phosphate and melphalan hydrochloride, work in different ways …

melphalan
myeloid leukemia
mycophenolate
chronic myelomonocytic leukemia
stem cell transplantation
  • 45 views
  • 27 Jan, 2021
  • 1 location
MSC and HSC Coinfusion in Mismatched Minitransplants

The present project aims at evaluating the capacity of MSC to improve one-year overall survival of patients transplanted with HLA-mismatched PBSC from related or unrelated donors after non-myeloablative conditioning. Co-infusion of MSC has been shown to facilitate engraftment of hematopoietic stem cell (HSC) in an immunodeficient mouse model. In addition, …

myeloablative conditioning
hematologic malignancy
graft versus host disease
fludarabine
mycophenolate mofetil
  • 100 views
  • 25 Jan, 2021
  • 11 locations