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Found 191 clinical trials
Filgrastim Cladribine Cytarabine and Mitoxantrone With Sorafenib in Treating Patients With Newly-Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

This phase I/II trial studies the side effects and best dose of filgrastim (granulocyte colony-stimulating factor [G-CSF]), cladribine, cytarabine, and mitoxantrone, when given together with sorafenib and to see how well they work in treating patients with newly-diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome (likely to be more aggressive). …

myeloid leukemia
hydroxyurea
granulocyte colony stimulating factor
hemolysis
blast cells
  • 78 views
  • 30 Apr, 2021
  • 1 location
Recombinant Human Interleukin-7 to Promote T-Cell Recovery After Cord Blood Transplant

myeloid leukemia, or myeloproliferative disease after a cord blood transplant. Umbilical cord blood is a source of blood-forming cells that can be used for transplant, also known as a graft. However

myeloid leukemia
granulocyte colony stimulating factor
graft versus host disease
chronic myeloid leukemia
colony stimulating factor
  • 0 views
  • 01 May, 2021
CLL1-CD33 cCAR in Patients With Relapsed and/or Refractory High Risk Hematologic Malignancies

Phase I, interventional, single arm, open label, treatment study to evaluate the safety and tolerability of CLL1-CD33 cCAR in patients with relapsed and/or refractory, high risk hematologic malignancies.

corticosteroids
graft versus host disease
hematologic malignancy
induction chemotherapy
raeb ii
  • 15 views
  • 27 May, 2021
  • 2 locations
Study of a Geriatric Assessment to Plan a Treatment Approach for Older People With Various Blood Disorders

, ,myelodysplastic syndromes, myeloproliferative neoplasms, or related blood disorders who are going to receive chemotherapy or another treatment to prepare the body for an allogeneic hematopoietic stem cell

leukemia
myeloid leukemia
transplant conditioning
chronic myeloid leukemia
chronic myelomonocytic leukemia
  • 0 views
  • 27 May, 2021
  • 7 locations
Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression

The standard Johns Hopkins' regimen will be used in study subjects, with the use of donor peripheral blood stem cells, rather than marrow. Clinical outcomes will be defined while focusing efforts on immune reconstitution focusing on immune checkpoint regulators after a related haploidentical stem cell transplant.

myeloid leukemia
hepatitis b
granulocyte colony stimulating factor
non-hodgkin's lymphoma
total body irradiation
  • 168 views
  • 12 May, 2021
  • 1 location
Thrombosomes in Bleeding Thrombocytopenic Patients Study

This prospective, multicenter, randomized, open-label, Phase 2, parallel, dose ranging, multidose trial will enroll patients into 3 Thrombosomes dose groups and 1 control liquid stored platelets (LSP) group in order to evaluate, in a dose-escalation manner, the safety, and impact on bleeding, and the preliminary effect on coagulation measures of …

  • 0 views
  • 09 May, 2021
  • 3 locations
Irradiation-based Myeloablative Conditioning Followed by Treg/Tcon Immunotherapy in HSCT

To evaluate if hyper-fractionated TBI or TMLI followed by Treg/Tcon adoptive immunotherapy improve cGvHD/disease free survival after allogeneic HSCT in patients affected by high-risk acute leukemias or other hematologic malignancy where HSCT is indicated.

myeloid leukemia
chronic lymphocytic leukemia
graft versus host disease
chronic myeloid leukemia
hematologic malignancy
  • 6 views
  • 23 Jan, 2021
  • 1 location
Cord Blood Transplant in Children and Young Adults With Blood Cancers and Non-malignant Disorders

This is a single-arm study to investigate 1-year treatment related mortality (TRM) in patients with life threatening non-malignant and malignant hematologic disorders who do not have a matched related donor for allogeneic transplantation.

consolidation chemotherapies
myelofibrosis
mycophenolate mofetil
cytopenia
blast cells
  • 0 views
  • 19 May, 2021
  • 1 location
Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Chemotherapy

This phase I trial studies the side effects and best dose of edetate calcium disodium or succimer in treating patients with acute myeloid leukemia or myelodysplastic syndrome undergoing chemotherapy. Edetate calcium disodium or succimer may help to lower the level of metals found in the bone marrow and blood and …

myeloid leukemia
refractory acute myeloid leukemia (aml)
calcium
cancer
succimer
  • 10 views
  • 03 Feb, 2021
  • 1 location
Effects of Prebiotics on Gut Microbiome in Patients Undergoing HSCT

The purpose of this study is to see whether hematopoietic stem cell transplant (HSCT) patients can consistently eat a diet rich in prebiotics. This type of diet may be helpful in maintaining diversity in the gastrointestinal (GI) system and therefore potentially decreasing risk of other GI problems.

  • 0 views
  • 31 Mar, 2021
  • 1 location