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Found 178 clinical trials
A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Haploidentical Hematopoietic Cell Transplantation

Neoplasms (MPN.

cyclophosphamide
graft versus host disease
myeloid leukemia
fludarabine
blast cells
  • 4 views
  • 27 Jan, 2021
A Phase 1 Trial of CD25/Treg-depleted DLI Plus Ipilimumab for Myeloid Disease Relapse After Matched-HCT

side effects are seen in patients with Acute Myeloid Leukemia (AML), Myelodysplastic Syndromes (MDS), Myeloproliferative Neoplasms (MPN), Chronic Myelomonocytic Leukemia (CMML), or Myelofibrosis (MF

ipilimumab
myeloid leukemia
graft versus host disease
myelodysplastic/myeloproliferative neoplasm
bone marrow procedure
  • 50 views
  • 25 Jan, 2021
Haplo Peripheral Blood Sct In GVHD Prevention

(MDS), myeloproliferative disorders (MPN), chronic myelomonocytic leukemic (CMML), chemosensitive hodgkin lymphoma (HL), or Non-Hodgkin lymphoma (NHL).who will have a blood stem cell transplantation

cyclophosphamide
renal function
graft versus host disease
bone marrow procedure
melphalan
  • 0 views
  • 25 Jan, 2021
Topotecan Hydrochloride and Carboplatin With or Without Veliparib in Treating Advanced Myeloproliferative Disorders and Acute Myeloid Leukemia or Chronic Myelomonocytic Leukemia

This phase II trial studies how well topotecan hydrochloride and carboplatin with or without veliparib work in treating patients with myeloproliferative disorders that have spread to other

graft versus host disease
myelodysplastic/myeloproliferative neoplasm
thrombocytosis
polycythemia vera
myelodysplastic/myeloproliferative neoplasms
  • 64 views
  • 03 Feb, 2021
  • 2 locations
Fractionated Gemtuzumab Ozogamicin in Treating Measurable Residual Disease in Patients With Acute Myeloid Leukemia High-Risk Myelodysplastic Syndrome or High-Risk Myeloproliferative Neoplasm

syndrome or high-risk myeloproliferative neoplasm. Gemtuzumab ozogamicin is a monoclonal antibody, called gemtuzumab, linked to a chemotherapy drug, called ozogamicin. Gemtuzumab is a form of targeted

gemtuzumab ozogamicin
remission
monoclonal protein
leukemia
monoclonal antibodies
  • 5 views
  • 26 Jan, 2021
  • 1 location
Azacitidine Venetoclax and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

This phase I/II trial studies the best dose of venetoclax when given together with azacitidine and pevonedistat and to see how well it works in treating patients with newly diagnosed acute myeloid leukemia. Drugs used in chemotherapy, such as azacitidine, work in different ways to stop the growth of tumor …

myelodysplastic/myeloproliferative neoplasm
thrombocytosis
direct bilirubin
myeloproliferative neoplasm
hydroxyurea
  • 40 views
  • 25 Feb, 2021
  • 1 location
Ivosidenib and Venetoclax With or Without Azacitidine in Treating Participants With IDH1 Mutated Hematologic Malignancies

This phase Ib/II trial studies the side effects and best dose of venetoclax and how well it works when given together with ivosidenib with or without azacitidine, in treating participants with IDH1-mutated hematologic malignancies. Venetoclax and ivosidenib may stop the growth of cancer cells by blocking some of the enzymes …

venetoclax
induction chemotherapy
bone marrow procedure
cancer
blast cells
  • 39 views
  • 06 Mar, 2021
  • 6 locations
Filgrastim Cladribine Cytarabine and Mitoxantrone With Sorafenib in Treating Patients With Newly-Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

This phase I/II trial studies the side effects and best dose of filgrastim (granulocyte colony-stimulating factor [G-CSF]), cladribine, cytarabine, and mitoxantrone, when given together with sorafenib and to see how well they work in treating patients with newly-diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome (likely to be more aggressive). …

cladribine
g-csf
mitoxantrone
leukapheresis
filgrastim
  • 78 views
  • 27 Jan, 2021
  • 1 location
Recombinant Human Interleukin-7 to Promote T-Cell Recovery After Cord Blood Transplant

myeloid leukemia, or myeloproliferative disease after a cord blood transplant. Umbilical cord blood is a source of blood-forming cells that can be used for transplant, also known as a graft. However

filgrastim
graft versus host disease
myeloid leukemia
granulocyte colony stimulating factor
chronic myeloid leukemia
  • 0 views
  • 31 Jan, 2021
Tocilizumab for the Prevention of Graft Versus Host Disease After Cord Blood Transplantation

The aim of the research in this study is to make participants' transplant safer by reducing the risk of developing GVHD and GVHD-related complications by giving participants a dose of the drug tocilizumab in addition to the standard approach for GVHD prevention. Tocilizumab reduces the risk of inflammation by blocking …

graft versus host disease
cyclosporine
remission
lymphocytic leukemia
leukemia
  • 71 views
  • 07 Mar, 2021
  • 1 location