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Found 178 clinical trials
Dual Vaccine Trial in Myeloproliferative Neoplasms

A phase I-II study in patients with mutated MPN by vaccinating with PD-L1 and Aginase1 peptides with Montanide ISA-51 as adjuvant, to monitor the immunological response to vaccination and

essential thrombocythemia
thrombocytosis
myeloproliferative disorder
pd-l1 peptide
polycythemia vera
  • 0 views
  • 23 Jan, 2021
A Study of TQ05105 Tablets in Subjects With Myeloproliferative Neoplasms

TQ05105 is a JAK2 inhibitors and can be used to treat JAK2 target-related diseases. The activation of the JAK/STAT pathway is related to abnormal proliferation, obstruction of apoptosis, and differentiation disorder of leukemia cells which is caused by genetic abnormalities and viral infection.

myelofibrosis
polycythemia
bone marrow procedure
leukemia
  • 0 views
  • 24 Jan, 2021
  • 2 locations
Intra-patient Dose Escalation Study to Investigate Safety and Feasibility of Vactosertib in Treating Anemic MPN Patients

patients with myeloproliferative neoplasms and it is thought that abnormal TGF signals cause many of the problems with blood cell formation in these diseases. The study design allows all patients to

ruxolitinib
hydroxyurea
myelodysplastic/myeloproliferative neoplasm
anemia
  • 0 views
  • 28 Jan, 2021
  • 1 location
Remotely Administered Diet Intervention to Impact Symptom Burden in Myeloproliferative Neoplasm

Myeloproliferative Neoplasm (MPN) is a chronic blood cancer without cure. The major clinical issues in MPN are 1) an increased risk of blood clots 2) symptoms thought to be driven by chronic

  • 0 views
  • 18 Feb, 2021
  • 1 location
A Study of INCB050465 in Combination With Ruxolitinib in Subjects With Myelofibrosis

The purpose of this study is to evaluate the safety, tolerability, and efficacy of the combination of parsaclisib and ruxolitinib in subjects with myelofibrosis.

  • 0 views
  • 26 Jan, 2021
  • 39 locations
Pilot Study for the Development of a Diagnostic Score to Differentiate Myeloproliferative Neoplasms.

Prospective study for the development of a non-invasive score for differentiating prefibrotic myelofibrosis from essential thrombocytosis and overt myelofibrosis.

  • 0 views
  • 23 Jan, 2021
  • 2 locations
Decitabine With Ruxolitinib or Fedratinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

myeloproliferative neoplasms (tumors). Drugs used in chemotherapy, such as decitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by

myelodysplastic syndromes
myelodysplastic/myeloproliferative neoplasm
thrombocytosis
blast cells
leukapheresis
  • 7 views
  • 26 Feb, 2021
  • 1 location
Ruxolitinib Phosphate and Azacytidine in Treating Patients With Myelofibrosis or Myelodysplastic Syndrome/Myeloproliferative Neoplasm

This phase II trial studies how well ruxolitinib phosphate and azacytidine work in treating patients with myelofibrosis or myelodysplastic syndrome/myeloproliferative neoplasm. Ruxolitinib

mds/mpd
myeloproliferative neoplasm
thrombocytosis
myeloproliferative disorder
neutrophil count
  • 65 views
  • 26 Jan, 2021
  • 1 location
Sotatercept in Treating Patients With Myeloproliferative Neoplasm-Associated Myelofibrosis or Anemia

This phase II trial studies the side effects of and how well sotatercept works in treating patients with myeloproliferative neoplasm-associated myelofibrosis or anemia. Sotatercept may stop the

cancer
conjugated bilirubin
direct bilirubin
myelofibrosis
myeloproliferative disorder
  • 1052 views
  • 24 Jan, 2021
  • 2 locations
Venetoclax Added to Fludarabine + Busulfan Prior to Transplant for AML MDS and MDS/MPN

/myeloproliferative neoplasm-unclassifiable (MDS/MPN-unclassifiable) and are planning to have an allogeneic hematopoietic stem cell transplant ("bone marrow transplant"). The goal of this research study is to (1

residual tumor
NRAS
transplant conditioning
flow cytometry
venetoclax
  • 31 views
  • 30 Jan, 2021
  • 1 location