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Found 186 clinical trials
HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant

This phase I trial studies the side effects and best dose of CD4+ and CD8+ HA-1 T cell receptor (TCR) T cells in treating patients with acute leukemia that persists, has come back (recurrent) or does not respond to treatment (refractory) following donor stem cell transplant. T cell receptor is …

blast crisis
acute leukemia
chronic myelomonocytic leukemia
residual tumor
myelodysplastic syndromes
  • 71 views
  • 29 Jan, 2021
  • 1 location
Personalized NK Cell Therapy After Chemotherapy and Cord Blood Transplant in Treating Patients With Myelodysplastic Syndrome Leukemia Lymphoma or Multiple Myeloma

This phase II clinical trial studies how well personalized natural killer (NK) cell therapy works after chemotherapy and umbilical cord blood transplant in treating patients with myelodysplastic syndrome, leukemia, lymphoma or multiple myeloma. This clinical trial will test cord blood (CB) selection for human leukocyte antigen (HLA)-C1/x recipients based on …

antithymocyte globulin
rituximab
lymphoma
chronic lymphocytic leukemia
acute leukemia
  • 58 views
  • 24 Jan, 2021
  • 1 location
Umbilical Cord Blood Transplant With Added Sugar and Chemotherapy and Radiation Therapy in Treating Patients With Leukemia or Lymphoma

This phase II trial studies how well an umbilical cord blood transplant with added sugar works with chemotherapy and radiation therapy in treating patients with leukemia or lymphoma. Giving chemotherapy and total-body irradiation before a donor umbilical cord blood transplant helps stop the growth of cells in the bone marrow, …

rituximab
white blood cell count
chromosomal abnormality
lymphoma
chronic lymphocytic leukemia
  • 36 views
  • 30 Jan, 2021
  • 2 locations
Combined Bone Marrow and Renal Transplantation for Hematologic Disorders With End Stage Renal Disease

This pilot trial offers the unique opportunity for both the treatment of multiple myeloma or systemic AL amyloidosis for which hematopoietic stem cell transplantation would be ordinarily indicated and the reversal of end-stage renal failure, while avoiding the risks associated with long-term standard anti-rejection therapy used in renal transplantation. The …

antithymocyte globulin
cell transplantation
hematologic disorder
remission
multiple myeloma
  • 171 views
  • 15 Mar, 2021
  • 1 location
Umbilical Cord Blood Transplant Cyclophosphamide Fludarabine and Total-Body Irradiation in Treating Patients With Hematologic Disease

This phase II trial studies how well giving an umbilical cord blood transplant together with cyclophosphamide, fludarabine, and total-body irradiation (TBI) works in treating patients with hematologic disease. Giving chemotherapy, such as cyclophosphamide and fludarabine, and TBI before a donor umbilical cord blood transplant helps stop the growth of cancer …

blast crisis
white blood cell count
lymphoma
chronic lymphocytic leukemia
acute leukemia
  • 125 views
  • 11 Apr, 2021
  • 3 locations
Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases

This is a treatment guideline for an unrelated umbilical cord blood transplant (UCBT) using a myeloablative preparative regimen for the treatment of hematological diseases, including, but not limited to acute leukemias. The myeloablative preparative regimen will consist of cyclophosphamide (CY), fludarabine (FLU) and fractionated total body irradiation (TBI).

blast crisis
lymphoma
chronic lymphocytic leukemia
acute leukemia
raeb
  • 146 views
  • 26 Jan, 2021
  • 1 location