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Found 186 clinical trials
Optimizing Prostate Cancer Treatment in Men With Advanced Local Disease

Multi-modality therapy that includes a brachytherapy implant improves outcomes in locally advanced prostate cancer when compared to other radiation-based treatments, but is also associated with more adverse side effects. The goal of the OPTiMAL trial is to reduce these side effects by using advanced imaging and biopsy techniques to locate …

bone scan
brachytherapy
androgens
transrectal ultrasound
external beam radiation therapy
  • 18 views
  • 24 Jan, 2021
  • 1 location
Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation

Background In allogeneic stem cell transplantation (SCT), stem cells are taken from a donor and given to a recipient. Sometimes the recipient s immune system destroys the donor s cells. Or donor immune cells attack the recipient s tissues, called graft-versus-host disease (GVHD). This is less likely when the recipient …

lymphoma
raeb i
multiple myeloma
cell transplantation
cytarabine
  • 23 views
  • 07 May, 2021
  • 2 locations
A Phase 1 Study of Ruxolitinib Steroids and Lenalidomide for Relapsed/Refractory Multiple Myeloma (RRMM) Patients

This is a phase 1, multicenter, open-label study evaluating the safety and efficacy of ruxolitinib, steroids and lenalidomide among MM patients who currently show progressive disease.

refractory multiple myeloma
monoclonal antibodies
lenalidomide
plasmacytoma
immunomodulatory imide drug
  • 36 views
  • 24 Jan, 2021
  • 10 locations
Treatment With Azacitidine of Recurrent Gliomas With IDH1/2 Mutation

Glioma are the most commun frequent brain tumour. Mutation of Isocitrate DeHydrogenase IDH1 or IDH2 genes affect 40% of gliomas, mostly grade II and III gliomas. Despite IDH mutated gliomas (IDHm glioma) have a better prognosis compared to the IDH wild type counterparts, they invariably recur after standard treatment with …

  • 0 views
  • 26 Jan, 2021
  • 1 location
Myeloproliferative Neoplasms (MPN) and COVID-19

experienced sudden death. Myeloproliferative Neoplasms (MPNs), which encompass polycythemia vera, essential thrombocythemia and primary myelofibrosis, are thrombophilic disorders with a natural propensity to

SARS
covid-19
thrombocytosis
polycythemia vera
myelofibrosis
  • 0 views
  • 24 Feb, 2021
  • 43 locations
Myeloproliferative Neoplasms (MPNs) Patient Registry

The mandate of this MPN registry is to collect clinical information, including molecular results, from consenting patients with a variety of MPNs at different time points during the course of

atypical chronic myeloid leukemia
thrombocytosis
polycythemia vera
post essential thrombocythemia myelofibrosis
myelofibrosis
  • 54 views
  • 08 Apr, 2021
  • 1 location
German MPN-Registry for BCR-ABL 1-Negative Myeloid Neoplasms (Study Group Ulm)

To register a large number of patients with the diagnosis of a BCR-ABL 1- negative myeloid neoplasm (according to WHO 2008 classification) in participating centers To store samples from all patients (e.g. bone marrow aspirate, peripheral blood, plasma, and buccal swap, skin biopsy samples in exceptional cases) To perform morphologic …

  • 5 views
  • 24 Jan, 2021
  • 33 locations
The National Myelodysplastic Syndromes (MDS) Study

Multi-center study enrolling patients suspected or newly diagnosed with myelodysplastic syndromes (MDS), myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) overlap disorder, or

myeloproliferative disorder
cytopenia
bone marrow procedure
  • 656 views
  • 26 Jan, 2021
  • 330 locations
Myeloproliferative Neoplastic Diseases Observatory From Brest

All patients diagnosed or followed in Brest University Hospital for Philadelphia negative myeloproliferative neoplasms will be included in this observational study. Myeloproliferative

myeloproliferative disorder
thrombocytosis
polycythemia vera
essential thrombocythemia
myelofibrosis
  • 16 views
  • 23 Jan, 2021
  • 1 location
Screening Gene Mutations in Myeloid Cancers by Next Generation Sequencing to Improve Treatment Results

Genetic mutations have closely linked to the pathogenesis and prognostication of myeloid cancers. In addition, a number of molecularly targeted agents have been developed in recent years. With the advent of next generation sequencing (NGS), we now are able to detect a wide range of mutations more rapidly, accurately, and …

  • 0 views
  • 23 Jan, 2021
  • 1 location