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Found 826 clinical trials
Featured trial
A Phase 1, Open-Label, Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid Neoplasms (LIMBER)

The purpose of this study is to evaluate the safety, tolerability, and preliminary efficacy of INCB057643 as monotherapy or combination with ruxolitinib for participants with myelofibrosis and other myeloid neoplasms.

myelofibrosis
cell transplantation
  • 0 views
  • 24 Oct, 2022
  • 21 locations
Featured trial
Phase 2 Study for SAR443820 in Participants With Amyotrophic Lateral Sclerosis (ALS) (HIMALAYA)  

This is a parallel treatment, Phase 2, randomized, double-blind study to assess the efficacy, safety, tolerability, PK, and PD of twice daily (BID) oral SAR443820 compared with placebo in male and female participants,18 to 80 years of age with ALS followed by an openlabel, longterm extension period. Study ACT16970 consists …

riluzole
body mass index
primary lateral sclerosis
edaravone
  • 40 views
  • 27 Jan, 2023
  • 18 locations
Featured trial
A Phase 1/2, Open-Label, Multicenter Study of INCB000928 Administered as a Monotherapy in Participants With Anemia Due to Myelodysplastic Syndromes or Multiple Myeloma

This Phase 1/2, open-label, dose-finding study is intended to evaluate the safety and tolerability, PK, PD, and efficacy of INCB000928 administered as monotherapy in participants with MDS or MM who are transfusion-dependent or present with symptomatic anemia.

multiple myeloma
chronic myelomonocytic leukaemia
anemia
carfilzomib
hydroxyurea
  • 1 views
  • 21 Oct, 2022
  • 12 locations
Featured trial
Eltrombopag Added to Standard Immunosuppression in Treatment-Naive Severe Aplastic Anemia

Background: Severe aplastic anemia is a rare and serious blood disorder. It happens when the immune system starts to attack the bone marrow cells. This causes the bone marrow to stop making red blood cells, platelets, and white blood cells. Standard treatment for this disease is horse-ATG and cyclosporine, which …

anemia studies
aplastic anemia
anemia
myelodysplastic syndromes
myelodysplastic syndrome (mds)
  • 172 views
  • 22 Dec, 2020
  • 1 location
Featured trial
Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS using CordIn(TM), Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells to Expedite Engraftment and Improve Transplant Outcome

Background: Severe aplastic anemia (SAA) and myelodysplastic syndrome (MDS) are bone marrow diseases. People with these diseases usually need a bone marrow transplant

anemia studies
myelodysplastic syndrome (mds)
aplastic anemia
myelodysplastic syndromes
  • 57 views
  • 22 Dec, 2020
  • 1 location
Featured trial
Do you suffer from lower back pain?

Do you suffer from lower back pain?

  • 1590 views
  • 08 Nov, 2020
  • 1 location
Fusion or no Fusion After Decompression of the Spinal Cord in Patients With Degenerative Cervical Myelopathy (MyRanC)

. The mean age for symptoms is 64 years and more men than women, 2.7:1, are affected. The most common level is C5-C6. DCM is the predominant cause of spinal cord dysfunction in the elderly worldwide

  • 22 views
  • 12 May, 2022
  • 1 location
Neurofeedback to Improve Spasticity After Incomplete Spinal Cord Injury

After incomplete spinal cord injury (iSCI), many people still have control over their upper and/or lower limbs, but secondary conditions such as spasticity impair the function they have left

  • 0 views
  • 05 May, 2022
  • 1 location
Amplify Gait to Improve Locomotor Engagement in Spinal Cord Injury

Spinal cord injury (SCI) affects ~42,000 Veterans. The VA provides the single largest network of SCI care in the nation. The lifetime financial burden of SCI can exceed $3 million. A major cost

  • 1 views
  • 20 Dec, 2021
  • 1 location
Spinal Cord Stimulation Therapy for Freezing of Gait in Parkinson's Syndrome Patients

Spinal cord stimulation may be a new therapeutic approach for freezing of gait. It's a multi-center, prospective, open label clinical study with a 12 months follow-up period, to investigate the

  • 0 views
  • 28 Jan, 2021
  • 1 location