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Found 59 clinical trials
Efficacy of Tyrosine Kinase Inhibition in Reducing Eosinophilia in Patients With Myeloid and/or Steroid-Refractory Hypereosinophilic Syndrome

The purpose of this study is to evaluate the safety and efficacy of the tyrosine kinase inhibitor, imatinib mesylate (Gleevec ) in reducing peripheral blood eosinophilia in patients with the myeloid form of hypereosinophilic syndrome (HES). Patients with the hypereosinophilic syndrome who meet a set of criteria designed to select …

  • 4 views
  • 23 Oct, 2022
  • 1 location
A Phase 1 Study of Safety, Pharmacokinetics and Preliminary Activity of TAS1553 in Subjects With Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML) and Other Myeloid Neoplasms

administered orally to participants ≥18 years of age with relapsed or refractory (R/R) acute myeloid leukemia (AML) or other myeloid neoplasms where approved therapies have failed or for whom known life

refractory acute myeloid leukemia (aml)
blast cells
blast crisis
  • 0 views
  • 25 Oct, 2022
  • 9 locations
CLAG·M Chemotherapy Followed Immediately by Related/Unrelated Reduced-Intensity Conditioning (RIC) Allogeneic Hematopoietic Cell Transplantation for Adults With Myeloid Malignancies at High Risk of Relapse: A Phase 1 Study

This phase I trial studies the best dose of total body irradiation when given with CLAG-M chemotherapy reduced-intensity conditioning regimen before stem cell transplant in treating patients with acute myeloid leukemia, myelodysplastic syndrome, or chronic myelomonocytic leukemia that has come back (relapsed) or does not respond to treatment (refractory). Giving …

  • 0 views
  • 13 Oct, 2022
  • 1 location
Vorinostat Dose-escalation After Allogeneic Hematopoietic Cell Transplantation

) for prevention of relapse of childhood myeloid malignancies.

azacitidine
transplant conditioning
cancer
graft versus host disease
vorinostat
  • 2 views
  • 04 Oct, 2022
  • 1 location
NTX-301 in MDS/AML

myeloid malignancies.

leukapheresis
gilbert's syndrome
cyclosporine
white blood cell count
leukemia
  • 0 views
  • 15 Dec, 2021
  • 1 location
Sodium Stibogluconate in the MDS/AML With One of the 65 Defined p53 Mutations

To evaluate the safety and effectiveness of Sodium Stibogluconate in the treatment of myelodysplastic syndrome/acute myeloid leukemia (MDS/AML) with p53 mutation from a defined list. The list includes 65 p53 mutations that were experimentally confirmed to be pharmacologically restored with tumor-suppressive function by antimonials.

leukemia
myeloid leukemia
  • 0 views
  • 18 Jun, 2021
  • 1 location
Combining Active and Passive DNA Hypomethylation

effectiveness of epigenetic therapy in patients with higher-risk myeloid malignancies, who are not candidates for allogeneic hematopoietic stem cell transplantation.

cmml-2
azacitidine
cancer
blast cells
chronic myelomonocytic leukemia
  • 0 views
  • 08 Oct, 2021
  • 6 locations
Ex Vivo Expanded NK Cells Infusion Decrease Relapse Post Hematopoietic Stem Cell Transplantation

This phase I/II studies the side effects and efficacy of natural killer cells after donor stem cell transplant and to see how well they work in treating patients with myeloid malignancies, or

myelodysplastic syndromes
mycophenolate mofetil
remission
transplant conditioning
mycophenolate
  • 0 views
  • 10 Mar, 2022
  • 1 location
Study of a Geriatric Assessment to Plan a Treatment Approach for Older People With Various Blood Disorders

This study will evaluate whether a geriatric assessment can lead to better treatment outcomes in older patients (age 60+) with a myeloid malignancy including acute myeloid leukemia

myelomonocytic leukemia
transplant conditioning
chronic myeloid leukemia
leukemia
myeloid leukemia
  • 0 views
  • 07 Oct, 2022
  • 7 locations
Hematopoietic Cell Transplantation Using Treosulfan-Based Conditioning for the Treatment of Bone Marrow Failure Diseases

This phase II trial tests whether treosulfan, fludarabine, and rabbit antithymocyte globulin (rATG) work when given before a blood or bone marrow transplant (conditioning regimen) to cause fewer complications for patients with bone marrow failure diseases. Chemotherapy drugs, such as treosulfan, work in different ways to stop the growth of …

bone marrow transplant
cancer
neutropenia
shwachman-diamond syndrome
fludarabine
  • 0 views
  • 22 Oct, 2022
  • 17 locations