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Found 59 clinical trials
A Randomized Trial of a Mobile Health Exercise Intervention for Older Adults With Myeloid Neoplasms (GO-EXCAP2)

This is a phase 2 randomized controlled trial (RCT) to assess the preliminary efficacy of the a mobile health exercise intervention (GO-EXCAP) versus a chemotherapy education control in 100 older patients with MN receiving outpatient chemotherapy on physical function and patient-reported outcomes (fatigue, mood, and quality of life). We will …

primary cancer
  • 0 views
  • 23 Mar, 2022
Venetoclax and CLAG-M for the Treatment of Acute Myeloid Leukemia and High-Grade Myeloid Neoplasms

patients with acute myeloid leukemia and high-grade myeloid neoplasms. Venetoclax may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Chemotherapy drugs, such

venetoclax
gilbert's syndrome
acute leukemia
colony stimulating factor
ejection fraction
  • 0 views
  • 13 May, 2022
  • 1 location
Epigenetics, Vitamin C, and Abnormal Blood Cell Formation - Vitamin C in Patients With Low-Risk Myeloid Malignancies (EVITA)

The primary purpose of this multi-centre, randomized, placebo-controlled, double-blind phase II study is to investigate if oral vitamin C may change the biology of low-risk myeloid malignancies

bone marrow procedure
chronic myelomonocytic leukemia
cytopenia
cancer
myelomonocytic leukemia
  • 52 views
  • 14 Feb, 2022
  • 4 locations
US Study of ECT-001-CB in Pediatric and Young Adult Patients With High-Risk Myeloid Malignancies

group of pediatric and young adult patients with high risk myeloid malignancies. 12 patients will be enrolled in the first stage of this 2-stage design protocol. If intervention is considered promising

  • 0 views
  • 22 Mar, 2022
  • 1 location
CPX-351 Versus Immediate Stem Cell Transplantation for the Treatment of High-Grade Myeloid Cancers With Measurable Residual Disease

This phase II trial studies the effect of CPX-351 followed by donor stem cell transplantation versus immediate donor stem cell transplantation in treating patients with high-grade myeloid

KIT
fludarabine
cell transplantation
remission
cytarabine
  • 0 views
  • 07 Oct, 2022
  • 1 location
Study of APG2575 Single Agent and Combination Therapy in Patients With Relapsed/Refractory AML

The purpose of this study is to assess the safety, pharmacokinetic of APG-2575 single agent and in combination with HHT/AZA in patients with relapsed/refractory AML and related myeloid

  • 0 views
  • 22 Mar, 2022
  • 7 locations
Evaluation of Antibody Response to High-Dose Seasonal Influenza Vaccination in Patients With Myeloid Malignancy Receiving Chemotherapy and Healthy Volunteers

This pilot research trial studies the antibody response to high-dose seasonal influenza vaccination in patients with myeloid malignancy receiving chemotherapy and healthy volunteers. Evaluating

Accepts healthy volunteers
cancer
  • 4 views
  • 06 May, 2022
  • 1 location
T-cell Receptor α/β Depleted Donor Lymphocyte Infusion

This pilot study is being conducted to treat patients who have a certain type of malignancy (lymphoid or myeloid) with immune effector cells after a T-cell depleted allogeneic hematopoietic cell transplantation (TCD HSCT). This study is designed to see whether an investigational cellular product of immune cells obtained from a …

cell transplantation
  • 0 views
  • 05 Jun, 2022
  • 1 location
Ph2 NK Cell Enriched DCIs w/wo RLR9 Agonist, DUK-CPG-001 From Donors Following Allogeneic SCT (NK-DCI)

This is a randomized, parallel phase II study to evaluate the rates of progression-free survival and unacceptable toxicity in patients receiving NK cell-enriched donor lymphocyte infusions (DLIs) when administered alone or administered with the TLR9 agonist, DUK-CPG-001, from a 7-8/8 HLA-matched related or unrelated donor (Cohort A) or 4-6/8 HLA-matched …

  • 0 views
  • 09 Apr, 2022
  • 1 location
CPX-351 or CLAG-M Regimen for the Treatment of Acute Myeloid Leukemia or Other High-Grade Myeloid Neoplasms in Medically Less-Fit Patients

acute myeloid leukemia or other high-grade myeloid neoplasms. Drugs used in chemotherapy, such as CPX-351, cladribine, cytarabine, G-CSF, and mitoxantrone, work in different ways to stop the growth of

azacitidine
cytarabine
daunorubicin
hemolysis
granulocyte colony stimulating factor
  • 0 views
  • 07 Oct, 2022
  • 1 location