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Found 759 clinical trials
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Study of Magrolimab Combinations in Participants With Myeloid Malignancies

therapies of venetoclax (Ven) and azacitidine (Aza) (Cohort 1), mitoxantrone, etoposide, and cytarabine (MEC) (Cohort 2) and CC-486 (Cohort 3) respectively in participants with acute myeloid leukemia (AML

  • 0 views
  • 29 Nov, 2021
  • 6 locations
None
SEL24/MEN1703 in Patients With Acute Myeloid Leukemia

The purpose of the clinical trial is to identify the maximum tolerated dose of SEL24/MEN1703 and to further investigate its safety profile in patients with Acute Myeloid Leukemia.

refractory acute myeloid leukemia (aml)
IDH2
  • 71 views
  • 09 Sep, 2021
  • 18 locations
None
TL-895 and KRT-232 Study in Acute Myeloid Leukemia

treatment of adults with FLT3 mutated Acute Myeloid Leukemia. Participants must be relapsed/refractory (e.g., having failed prior therapy) to be eligible for this study.

TP53
tyrosine
  • 0 views
  • 24 Sep, 2021
  • 22 locations
None
KRT-232 and TKI Study in Chronic Myeloid Leukemia

This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with Ph+ Chronic Myeloid Leukemia (CML) who have relapsed or are refractory or

dasatinib
leukemia
chronic phase chronic myeloid leukemia
nilotinib
kinase inhibitor
  • 12 views
  • 11 Aug, 2021
  • 6 locations
None
Unrelated Donor Transplant Versus Immune Therapy in Pediatric Severe Aplastic Anemia

The purpose of this study is to determine the feasibility of comparing outcomes of patients treated de novo with immunosuppressive therapy (IST) versus matched unrelated donor (MUD) hematopoietic stem cell transplant (HSCT) for pediatric acquired severe aplastic anemia.

total body irradiation
immunosuppression
rabbit atg
neutrophil count
fludarabine
  • 28 views
  • 08 Aug, 2021
  • 13 locations
None
Low-Dose Oral Imatinib for Scleroderma Pulmonary Involvement

The purpose of this study is to verify effect and tolerability of imatinib on pulmonary and skin fibrosis in patients affected by systemic sclerosis.

cyclophosphamide
immunosuppressive agents
fibrosis
pulmonary function test
imatinib
  • 33 views
  • 07 Nov, 2020
  • 1 location
None
Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)

Background Severe aplastic anemia (SAA) is a rare and serious blood disorder. It causes the immune system to turn against bone marrow cells. Standard treatment for SSA is a combination of 3 drugs (Cyclosporine [CsA], Eltrombopag [EPAG], and horse anti-thymocyte globulin [h-ATG]). Researchers want to see if starting people at …

blood disorder
eltrombopag
immunosuppression
neutrophil count
reticulocyte count
  • 2 views
  • 08 Nov, 2021
  • 1 location
None
Post Transplant High-Dose Cy as GvHD Prophylaxis in 1 HLA Mismatched Unrelated HSCT for Myeloid Malignancies

The experimental treatment consists in the application of a therapeutic strategy with post Transplant High-Dose Cyclophosphamide as GvHD Prophylaxis in Patients Receiving 1-Antigen/Allele HLA Mismatched (7/8 matched) Unrelated Hemopoietic Stem Cell Transplantation for Myeloid Malignancies.

  • 0 views
  • 27 Aug, 2021
  • 33 locations
None
Comparison Between Two Dose Levels of Daunorubicin and Between One vs. Two Induction Cycles for Adult Patients With AML

The proposed trial will address two clinically important questions for younger patients with newly diagnosed acute myeloid leukemia (AML): the optimal dose of daunorubicin in induction therapy

acute promyelocytic leukemia
ejection fraction
blast cells
daunorubicin
minimal residual disease
  • 33 views
  • 19 Sep, 2021
  • 41 locations
None
Long-acting Low Dose Ropeginterferon for Chronic Myeloid Leukemia Treated With Bosutinib From Diagnosis

To study the efficacy and safety of combination of Ro-Peg-interferon-2b (RoPegIFN) with Bosutinib (BOS) in comparison to BOS monotherapy, as frontline therapy for newly diagnosed chronic myeloid

anagrelide
remission
leukemia
lipase
interferon
  • 1 views
  • 11 Apr, 2021
  • 21 locations