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Found 724 clinical trials
Featured trial
The Axcelsius Study: A Study of ONO-7475 in Patients with Acute Leukemias

drug called venetoclax. The purpose of this study is to see whether the study drug and venetoclax can work together to slow down the growth of cells that cause acute myeloid leukemia (AML).

blast cells
venetoclax
induction chemotherapy
myeloid leukemia
refractory acute myeloid leukemia (aml)
  • 20 views
  • 11 Jan, 2022
  • 4 locations
Featured trial
ACCL0993: A Randomized Open-Label Trial of Caspofungin versus Fluconazole to Prevent Invasive Fungal Infection in Children Undergoing Chemotherapy for Acute Myeloid Leukemia (AML)

ACCL0993: A Randomized Open-Label Trial of Caspofungin versus Fluconazole to Prevent Invasive Fungal Infection in Children Undergoing Chemotherapy for Acute Myeloid Leukemia (AML)

  • 130 views
  • 08 Nov, 2020
  • 1 location
Featured trial
Celgene MDS-AML Registry Connect

Celgene MDS-AML Registry Connect

  • 78 views
  • 08 Nov, 2020
  • 1 location
Study of Biomarker-Based Treatment of Acute Myeloid Leukemia

-M1)." The specific subtype of acute myeloid leukemia will determine which sub-study, within this protocol, a participant will be assigned to evaluate investigational therapies or combinations with

  • 44 views
  • 22 Apr, 2022
  • 17 locations
Research Study for Treatment of Children and Adolescents With Acute Myeloid Leukaemia 0-18 Years

This study evaluates the effect of different induction courses in children and adolescents with newly diagnosed acute myeloid leukemia. In the first course patients are randomised to receive

  • 26 views
  • 21 Jan, 2021
  • 34 locations
Study to Determine the Dose and Safety of Asciminib in Pediatric Patients With Chronic Myeloid Leukemia

The aim of this study is to support development of asciminib in the pediatric population (1 to <18 years) previously treated with one or more TKIs. Full extrapolation of the efficacy of asciminib from adult to pediatric patients will be conducted. Full extrapolation is based on the concept that CML …

asciminib
leukemia
basophils
  • 0 views
  • 10 May, 2022
  • 16 locations
Optimization of TKIs Treatment and Quality of Life in Ph+ CML Patients ≥60 Years in Deep Molecular Response

In this phase III clinical randomized study, "fixed" intermittent administration (one month ON/one month OFF) of TKIs (control arm), will be compared with "progressive" intermittent administration (one month ON/one month OFF for the 1st year; one month ON/two months OFF for the 2nd year; one month ON/three months OFF for …

kinase inhibitor
tasigna
gleevec
imatinib
nilotinib
  • 3 views
  • 01 May, 2022
  • 1 location
Stopping Tyrosine Kinase Inhibitors in Affecting Treatment-Free Remission in Patients With Chronic Phase Chronic Myeloid Leukemia

This phase II trial studies how stopping tyrosine kinase inhibitors will affect treatment-free remission in patients with chronic myeloid leukemia in chronic phase. When the level of disease is

  • 2 views
  • 15 May, 2022
  • 83 locations
CC-486 and Venetoclax for Acute Myeloid Leukemia

This is an open label, dose escalation Phase I single institution pilot study for relapsed and refractory AML patients using CC-486 (oral azacitidine) with venetoclax. At the completion of dose escalation and after establishment of the MTD or recommended dose of CC-486 with venetoclax, an expansion phase will commence, using …

  • 0 views
  • 20 Apr, 2022
  • 1 location
Dexamethasone in Refractory or First Relapsed Acute Myeloid Leukemia

regrowth and relapse. Moreover, it has been experimentally shown that leukemic cells in acute myeloid leukemia patients who relapse become sensitive to glucocorticoids treatment highlighting a novel

  • 0 views
  • 25 Jan, 2021
  • 5 locations