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Found 11 clinical trials
A Phase 2 Study of CPI-0610 With and Without Ruxolitinib in Patients With Myelofibrosis

Phase 1 Part (Complete): Open-label, sequential dose escalation study of CPI-0610 in patients with previously treated Acute Leukemia, Myelodysplastic Syndrome, Myelodysplastic/Myeloproliferative

myelofibrosis
acute leukemia
myeloproliferative disorder
growth factor
janus kinase inhibitor
  • 242 views
  • 18 Jan, 2021
  • 59 locations
Azacitidine and Quizartinib for the Treatment of Myelodysplastic Syndrome or Myelodysplastic/Myeloproliferative Neoplasm With FLT3 or CBL Mutations

myelodysplastic/myeloproliferative neoplasm with FLT3 or CBL mutations. Chemotherapy drugs, such as azacitidine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping

hydroxyurea
quizartinib
myeloproliferative disorder
growth factor
azacitidine
  • 0 views
  • 24 Jan, 2021
Ruxolitinib Phosphate and Azacytidine in Treating Patients With Myelofibrosis or Myelodysplastic Syndrome/Myeloproliferative Neoplasm

This phase II trial studies how well ruxolitinib phosphate and azacytidine work in treating patients with myelofibrosis or myelodysplastic syndrome/myeloproliferative neoplasm. Ruxolitinib phosphate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as azacytidine, work in different …

absolute neutrophil count
direct bilirubin
myeloproliferative disorder
neutrophil count
azacitidine
  • 65 views
  • 17 Dec, 2020
  • 1 location
Azacitidine Venetoclax and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

This phase I/II trial studies the best dose of venetoclax when given together with azacitidine and pevonedistat and to see how well it works in treating patients with newly diagnosed acute myeloid leukemia. Drugs used in chemotherapy, such as azacitidine, work in different ways to stop the growth of tumor …

direct bilirubin
chromosomal abnormality
myeloproliferative disorder
leukemia
cancer
  • 40 views
  • 14 Oct, 2020
  • 1 location
Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial

This phase Ib trial determines if samples from a patient's cancer can be tested to find combinations of drugs that provide clinical benefit for the kind of cancer the patient has. This study is also being done to understand why cancer drugs can stop working and how different cancers in …

direct bilirubin
multiple myeloma
panobinostat
bone scan
ct scan
  • 0 views
  • 28 Dec, 2020
  • 1 location
Early Diagnosis of Aspergillosis in Patients at High Risk of Fungal Infection Caused by Treatment for Hematologic Cancer or Other Disease

RATIONALE: Studying ways to diagnose fungal infections early may help doctors plan the best treatment. PURPOSE: This clinical trial is studying laboratory tests to see how well they find aspergillosis early in patients at high risk of fungal infection caused by treatment for hematologic cancer or other disease.

hematologic malignancy
fungal infection
cancer
PCR test
  • 52 views
  • 07 Nov, 2020
  • 1 location
Myeloproliferative Neoplasms (MPNs) Patient Registry

The mandate of this MPN registry is to collect clinical information, including molecular results, from consenting patients with a variety of MPNs at different time points during the course of their disease.

ringed sideroblasts
atypical chronic myeloid leukemia
essential thrombocythemia
myelofibrosis
myelomonocytic leukemia
  • 54 views
  • 23 Jan, 2021
  • 1 location
Study of MGUS Smoldering Myeloma Early MDS and CLL to Assess Molecular Events of Progression and Clinical Outcome

Blood cancers occur when the molecules that control normal cell growth are damaged. Many of these changes can be detected by directly examining parts of the cancer or cells in blood. Several alterations that occur repeatedly in certain types of blood cancers have already been identified, and these discoveries have …

multiple myeloma
gammopathy
alkylating agents
lymphocytosis
myeloproliferative disorder
  • 140 views
  • 24 Jan, 2021
  • 2 locations
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

This study is an access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) in pediatric and adult patients with hematologic malignancies and other indications.

hematologic malignancy
cancer
  • 643 views
  • 24 Jan, 2021
  • 140 locations
Screening Individuals and Families at High Risk for Hematologic Cancers

RATIONALE: Evaluating genetic and environmental factors in individuals and families at high risk of developing hematologic cancer may help doctors plan more effective treatments. PURPOSE: Screening trial to determine if genetic and environmental factors contribute to the development of hematologic cancer in individuals and families at high risk for cancer.

cancer
  • 56 views
  • 07 Nov, 2020
  • 1 location