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Found 362 clinical trials
Sterile Inflammation and Molecular Aberrations in MDS

The objective of this study is the description of the possible association between genetic mutation/aberration profiles, inflammatory tonus and clinical phenotype based on PROMs and HRQoL. Apart from gaining a better understanding of the causal correlation between genetics, sterile inflammatory processes and QoL (e.g. fatigue) in MDS, this study is …

TP53
IDH2
  • 1 views
  • 06 Mar, 2021
  • 1 location
Monitoring Mutational Burden in Low Risk MDS Patients Using Sequential Peripheral Blood Samples

Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell malignancies. Somatic cytogenetic and molecular aberrations and the evolution of subclonal malignant

bone marrow procedure
erythropoietin
cancer
myeloid leukemia
leukemia
  • 0 views
  • 08 Aug, 2021
  • 1 location
Study Investigating the Interactions of Bone and Hematopoiesis in the Elderly

myelodysplastic syndromes (MDS).

bone marrow procedure
  • 10 views
  • 22 Aug, 2021
  • 2 locations
Development and Prospective Validation of a Standardized Flow Cytometric Assay of Peripheral Blood Neutrophil Myeloperoxidase Expression for Ruling Out Myelodysplastic Syndromes.

Myelodysplastic syndromes (MDS) comprise a heterogeneous group of clonal bone marrow neoplasms that predominate in the elderly, with a median age at diagnosis of 70 years. The diagnosis of MDS

bone marrow procedure
cytopenia
  • 0 views
  • 26 Jan, 2021
  • 1 location
Interplay Between Immune and Metabolic Programs in Myelodysplastic Syndromes

Myelodysplastic syndromes (MDS) are a pre-leukemic condition with an extremely poor prognosis despite current treatments that justify new therapeutic approaches. Various studies have described

  • 0 views
  • 25 Mar, 2021
  • 1 location
Constitution of a Biological Cohort Following Bone Marrow Sampling From MDS or AML Patients and Age-matched Healthy Donors

It is of clinical significance to better characterize the intrinsic defects harbored by mesenchymal stromal cells (MSC) in Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML

bone marrow procedure
myelodysplastic syndromes
myeloid leukemia
leukemia
myelodysplasia
  • 11 views
  • 03 Feb, 2021
  • 3 locations
Frailty Phenotype Assessments to Optimize Treatment Strategies for Older Patients With Hematologic Malignancies

The purpose of this research study is to determine if frailty assessments can be used to predict how well patients aged 60 years and older will do after chemotherapy, CAR T-cell therapy, or allogeneic stem cell transplant.

bone marrow procedure
hematologic malignancy
cancer
bone marrow transplant
leukemia
  • 5 views
  • 26 Jan, 2021
  • 1 location
Prospective Observational Study of Long-term Pathogenic Treatment of Elizaria

This is prospective observational study of long-term pathogenic treatment of Elizaria in patients with paroxysmal nocturnal hemoglobinuria.

  • 0 views
  • 29 Jan, 2021
  • 8 locations
AML/MDS Drug Sensitization by in Vivo Chemotherapy Administration

In this study, the investigators will explore the feasibility of ex vivo drug screening to predict sensitivity to chemotherapy resistance and to identify novel synergy between chemotherapies.

azacitidine
cytarabine
gemtuzumab
blast cells
midostaurin
  • 0 views
  • 16 May, 2021
  • 1 location
Haploinsufficiency of the RBM22 and SLU7 Genes in Del(5q) Myelodysplastic Syndromes

Myelodysplastic syndromes (MDS) are malignant hematopathies of the elderly characterized by persistent cytopenias and the presence of deregulated clonal hematopoiesis. The risk of progression to

  • 1 views
  • 28 Jan, 2021
  • 3 locations