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Found 114 clinical trials
A Phase 3, Double-blind, Randomized Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK Inhibitor Therapy and Who Require Red Blood Cell Transfusions (INDEPENDENCE)

The purpose of this Phase 3 study is to evaluate the efficacy and safety of Luspatercept compared with placebo in subjects with myeloproliferative neoplasm (MPN)-associated Myelofibrosis (MF

anemia
vasectomy
cancer
bilateral oophorectomy
  • 36 views
  • 28 Oct, 2022
  • 163 locations
Open Label, Multi-center, Phase IV Study of Ruxolitinib or Ruxolitinib and Panobinostat Combination, for Patients Who Have Completed Prior Global Novartis or Incyte Sponsored Studies

This is a long term safety study for patients that have been treated with either ruxolitinib or a combination of ruxolitinib with panobinostat, on a Novartis or Incyte sponsored study, who have been judged by the study Investigator to benefit from ongoing treatment.

ruxolitinib tablets
panobinostat capsules
ruxolitinib
panobinostat
progressive disease
  • 148 views
  • 15 Oct, 2022
  • 28 locations
The Prophet Trial -Pilot Study to Assess Safety and Efficacy of a Novel Atrial Flow Regulator (AFR) in Patients With Pulmonary Hypertension (AFR-Prophet)

This study aims to investigate safety and efficacy of Occlutech® AFR device in patients with severe pulmonary hypertension (PH).

pulmonary arterial pressure
heart failure
right ventricular failure
  • 46 views
  • 07 Oct, 2022
  • 12 locations
A Phase 2, Open-Label, Ascending Dose Study of KER-050 for the Treatment of Anemia in Patients With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS)

The purpose of this study is to evaluate the effects of KER-050 on anemia in patients with very low, low or intermediate risk MDS.

bone marrow procedure
anemia
blood transfusion
  • 72 views
  • 28 Oct, 2022
  • 18 locations
Deep Phenotyping of Cutaneous T Cell Lymphoma, Type Mycosis Fungoides

Mycosis fungoides (MF) is an ultra-orphan disease of which the etiology remains unknown. MF is diagnosed by correlating clinical appearance with histopathological analysis of often multiple

methotrexate
lymphoma
Accepts healthy volunteers
skin disease
immunosuppressive therapy
  • 0 views
  • 26 Apr, 2022
  • 1 location
Ultra Low Dose Radiation Therapy in Treating Patients With Mycosis Fungoides

This phase II trial studies how well ultra low dose radiation therapy works in treating patients with mycosis fungoides. Radiation therapy uses high energy x-rays to kill tumor cells and shrink

measurable disease
beta-hcg
low dose radiation therapy
tumor cells
human chorionic gonadotropin
  • 277 views
  • 25 May, 2022
  • 1 location
Pembrolizumab in Treating Patients With Stage IB-IV Mycosis Fungoides

This phase II trial studies how well pembrolizumab works in treating patients with stage IB-IV mycosis fungoides. Antibodies, such as pembrolizumab, may interfere with the ability of cancer

metastases
pet scans
sezary syndrome
measurable disease
neutrophil count
  • 9 views
  • 10 Apr, 2022
  • 1 location
Dosing of Brentuximab Vedotin for Mycosis Fungoides, Sezary Syndrome Patients

The purpose of this study is to test any good and bad effects of the study drug called brentuximab vedotin at a lower dose than is FDA-approved.

sezary syndrome
systemic steroids
immunomodulator
cancer therapy
mycosis fungoides and sezary syndrome
  • 115 views
  • 05 Mar, 2022
  • 8 locations
Mogamulizumab + Low-Dose Total Skin Electron Beam Tx in Mycosis Fungoides & Sézary Syndrome

The purpose of this study is to determine the efficacy of the combination of LD-TSEBT and mogamulizumab in patients with MF and SS. And to evaluate the secondary measures of clinical benefit of

vorinostat
metastases
lymphoma
progressive disease
sezary syndrome
  • 19 views
  • 25 Apr, 2022
  • 1 location
Mogamulizumab and Extracorporeal Photopheresis for the Treatment of Sezary Syndrome or Mycosis Fungoides

immune response against other lymphoma cells. Giving mogamulizumab together with ECP may work better in treating patients with Sezary syndrome or mycosis fungoides compared to either therapy alone.

vorinostat
skin biopsy
methotrexate
lymphoma
sezary syndrome
  • 0 views
  • 10 Jul, 2022
  • 1 location