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Found 137 clinical trials
T Lymphocytes for the Treatment of AdV, CMV, EBV, BKV and Aspergillus Fumigatus Infections After Allogeneic Stem Cell Transplantation (Penta-STs-001)

The purpose of the study is to determine the feasibility, safety and efficacy of administering rapidly-generated donor-derived pentavalent-specific T cells (Penta-STs) to mediate antiviral and antifungal activity in hematopoietic stem cell transplant (HSCT) recipients with AdV, EBV, CMV, BKV or Aspergillus fumigatus (AF) infection/ reactivation or with active disease.

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 2 locations
Inpatient Package to Reduce HIV and AIDS-related Death in Zambia (IPADZ)

Early post-discharge mortality is high among HIV-infected Zambians admitted to the hospital. Likely this is in part due to missed opportunities to identify lethal coinfections and optimize HIV care during admission (and before discharge). In this study the investigators will develop and pilot a new approach to inpatient HIV care …

HIV Infection
co-infections
  • 0 views
  • 07 Oct, 2022
  • 1 location
Neuro-pharmacological Study of Ketoconazole for High-grade Gliomas

doctors already use for fungal infections and is thought to be able to effect tumor cells. As treatments for this type of brain tumor are limited, it is hoped that the results of this study will help to

EGFR
brain tumor
tumor cells
  • 0 views
  • 04 Oct, 2022
  • 1 location
Neuro-pharmacological Properties of Repurposed Posaconazole in Glioblastoma: A Phase 0 Clinical Trial

doctors already use for fungal infections and is thought to be able to effect tumor cells. As treatments for this type of brain tumor are limited, it is hoped that the results of this study will help to

brain tumor
tumor cells
  • 0 views
  • 04 Oct, 2022
  • 1 location
Evaluating the Healing of Diabetic Foot Ulcers With Compounded Anti-Infective Irrigation Therapy

ulcers and thereby provide a new therapeutic option for health care providers treating high-risk patients with DFUs regardless if secondary fungal infections are present. Participants diagnosed

type 2 diabetes mellitus
vancomycin
debridement
diabetes
antibiotics
  • 0 views
  • 22 Oct, 2021
  • 1 location
Durvalumab With or Without Lenalidomide in Treating Patients With Relapsed or Refractory Cutaneous or Peripheral T Cell Lymphoma

This randomized phase I/II trial studies the best dose and side effects of durvalumab and to see how well it works with or without lenalidomide in treating patients with cutaneous or peripheral T cell lymphoma that has come back and does not respond to treatment. Monoclonal antibodies, such as durvalumab, …

monoclonal protein
lenalidomide
lymphoma
cutaneous lymphoma
monoclonal antibodies
  • 64 views
  • 25 Mar, 2022
  • 1 location
A Phase Ib Trial Combining Bexarotene With Ultra-Low Dose Total Skin Electron Beam (Tseb) Radiotherapy For The Treatment Of Diffuse Cutaneous T-Cell Lymphomas

The researchers are doing this study to test the safety of combining bexarotene with TSEB radiotherapy in people who have a common form of CTCL called mycosis fungoides (MF). Bexarotene

cutaneous t-cell lymphoma
lymphoma
cancer
mycosis
mycosis fungoides
  • 0 views
  • 16 Oct, 2022
  • 1 location
A Pilot Study of Acalabrutinib in Relapsed/Refractory Primary and Secondary CNS Lymphomas

looking to see if acalabrutinib can shrink cancer cells. The participants will be given acalabrutinib and isavuconazole, because isavuconazole helps in preventing fungal infections that may occur

lymphoma
corticosteroids
cancer
ibrutinib
mantle cell lymphoma
  • 1 views
  • 08 Apr, 2022
  • 2 locations
Itacitinib and Tocilizumab for Steroid Refractory Acute Graft Versus Host Disease (GVHD)

response Estimate the incidence of primary disease relapse while on study treatment Estimate the incidence of infections including viral reactivation, bacterial infections and fungal

  • 0 views
  • 13 May, 2022
  • 2 locations
Romidepsin and Parsaclisib for the Treatment of Relapsed or Refractory T-Cell Lymphomas

This phase I trial finds the appropriate parsaclisib dose level in combination with romidepsin for the treatment of T-cell lymphomas that have come back (relapsed) or that have not responded to standard treatment (refractory). The other goals of this trial are to find the proportion of patients whose cancer is …

corticosteroids
systemic steroids
cancer
hysterectomy
brentuximab
  • 1 views
  • 01 May, 2022
  • 1 location