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Found 140 clinical trials
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Co-Infusion of Umbilical Cord Blood and Haploidentical CD34+ Cells Following Nonmyeloablative Conditioning as Treatment for Severe Aplastic Anemia and MDS Associated with Severe Neutropenia Refractory to Immunosuppressive Therapy

, mycophenolate mofetil and prednisone to prevent rejection of the donated cells and to prevent graft-versus-host disease (GVHD), a complication of stem cell transplants in which the donor s immune cells destroy

anemia
myelodysplastic syndromes
anemia studies
aplastic anemia
myelodysplastic syndrome (mds)
  • 48 views
  • 22 Dec, 2020
  • 1 location
featured
Research Study of ATG and Rituximab in Renal Transplantation (RESTARRT)

Research Study of ATG and Rituximab in Renal Transplantation (RESTARRT)

  • 1078 views
  • 23 Nov, 2020
  • 5 locations
featured
A Phase 2 Double-Blind, Placebo Controlled Multi-Center Study to Evaluate the Efficacy and Safety of Tcelna in Subjects With Secondary Progressive Multiple Sclerosis

A Phase 2 Double-Blind, Placebo Controlled Multi-Center Study to Evaluate the Efficacy and Safety of Tcelna in Subjects With Secondary Progressive Multiple Sclerosis

  • 204 views
  • 08 Nov, 2020
  • 1 location
featured
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABT-494 for Induction and Maintenance Therapy in Subjects With Moderately to Severely Active Ulcerative Colitis

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABT-494 for Induction and Maintenance Therapy in Subjects With Moderately to Severely Active Ulcerative Colitis

  • 248 views
  • 23 Nov, 2020
  • 1 location
Adalimumab vs. Conventional Immunosuppression for Uveitis Trial

Non-infectious intermediate, posterior, and panuveitides are chronic, potentially-blinding diseases. Vision-threatening cases require long-term therapy with oral corticosteroids and immunosuppression. Based upon preliminary data, adalimumab, a fully-human, anti-TNFmonoclonal antibody, now US FDA-approved for uveitis treatment, may be a superior corticosteroid-sparing agent than conventional immunosuppressive drugs. The ADVISE Trial is multicenter randomized, …

prednisone
corticosteroids
monoclonal antibodies
adalimumab
immunosuppressive agents
  • 103 views
  • 13 Aug, 2020
  • 27 locations
Extracorporeal Photopheresis for Medicare Recipients of Lung Allografts

The primary aims of this study is to determine the efficacy and tolerability of Extracorporeal Photopheresis (ECP) for the treatment of either refractory (240) or newly diagnosed (739) Bronchiolitis Obliterans Syndrome (BOS) in patients after lung transplantation.In compliance with the Centers for Medicare and Medicaid Services' (CMS) Coverage with Evidence …

  • 5 views
  • 02 Sep, 2020
  • 21 locations
Mycophenolate Mofetil Versus Azathioprine in Treatment Naive Autoimmune Hepatitis

intolerant for, azathioprine. Mycophenolate mofetil (MMF) has surpassed azathioprine as therapy to prevent organ transplant rejection and is sometimes used as an alternative option for autoimmune hepatitis

liver disease
prednisolone
remission
azathioprine
mycophenolate
  • 26 views
  • 08 Nov, 2020
  • 1 location
Efficacy and Safety of Tacrolimus Versus Mycophenolate in Lupus Nephritis

Prospective, randomized, parallel-group controlled, open-label, international (Asian) multicenter, comparison of corticosteroids combined with TAC and corticosteroids combined with MMF.

nephritis
corticosteroids
tacrolimus
hematuria
proteinuria
  • 67 views
  • 11 Nov, 2020
Mycophenolate Mofetil in Antiretroviral Na ve Patients 2 (MAN2 Study)

The purpose of the study is to evaluate whether mycophenolate mofetil (MMF) can treat the chronic hyperactivation of the immune system and (partly) prevent the decrease of the CD4+ T-cell

AIDS
hiv-1 infection
hiv-1 rna measurement
antiretroviral therapy
antiretroviral agents
  • 17 views
  • 07 Nov, 2020
  • 5 locations
Fixed-dose Versus Concentration-controlled Mycophenolate Mofetil for the Treatment of Active Lupus Nephritis

A randomized open-label study of fixed-dose versus concentration-controlled mycophenolate mofetil for treatment of active lupus nephritis.

nephritis
mycophenolate
  • 15 views
  • 21 Apr, 2019