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Found 133 clinical trials
Fighting Immunosenescence and Promoting Immunity by a Fasting-mimicking Diet Elderly.

Background: Immunosenescence is an aging-dependent phenomenon underlying age dependent deterioration in the function of the immune system, characterized by a decline in B and T cells with a relative increase in natural killer (NK) cells. Aging also promotes chronic inflammation accompanied by increased levels of pro-inflammatory cytokines. Both immunosenescence and …

corticosteroids
fasting
insulin
cytokines
diabetes
  • 0 views
  • 31 Oct, 2021
  • 1 location
Chocolate and Physical Exercise to Reduce Malnutrition in Pre-dementia Aged People (Choko-AGE)

We hypothesize that the antioxidant and cytoprotective functions of vitamin E combined with the cortisol-lowering effect of chocolate polyphenols and physical activity may help prevent the age-dependent decline of mitochondrial function and nutrient metabolism in skeletal muscle, key underpinning events in protein-energy malnutrition (PEM) and muscle wasting in the elderly. …

mental state examination
mini-mental state examination
dementia
mild dementia
cognitive impairment
  • 0 views
  • 25 May, 2022
  • 1 location
Plasma Protein Binding and PK/PD of Total and Unbound Temocillin Non-ICU Patients (TEMODELTA)

Multidrug resistance towards Gram-negative pathogens makes essential the re-examination of older compounds. Temocillin is a penicillin originally marketed in the 1980s but then largely abandoned. It, however, shows a marked ß-lactamase stability (including most classical and extended-spectrum TEM, SHV, CTX-M enzymes and AmpC ß-lactamase). Temocillin is approved for the treatment …

bacteremia
abdominal infection
antibiotics
  • 0 views
  • 20 Jun, 2022
  • 1 location
Impact of Physical Exercise at a Hospital

Aims and Hypotheses Aims to investigate associations between an intelligent exercise training intervention and clinical health parameters, well-being, sick leave and productivity at Nordsjællands Hospital (NOH) to generate data and experiences to a larger cluster randomized trial with more included departments at NOH to analyze how the intervention could be …

Accepts healthy volunteers
  • 0 views
  • 26 Apr, 2022
  • 1 location
Ezetimibe Utilization Early After Acute Myocardial Infarction "EzAMI Trial"

Rationale Patients with acute coronary syndromes are at an increased risk for recurrent adverse coronary events, particularly during the early period following their initial presentation. Early (in-hospital) initiation of high-intensity statins reduces the risk of recurrent events and is therefore recommended by the best current practice guidelines.(1,2) However, the delayed …

combination therapy
ezetimibe
evolocumab
statin therapy
hmg-coa reductase inhibitors
  • 0 views
  • 06 Aug, 2021
  • 1 location
How is Aerobic Exercise Compared to Localized Pain Relief Exercises in Patients With Jaw Pain and Neck Pain? Pilot Study

Musculoskeletal (MSK) disorders are some of the most burdensome health issues in the world and the leading causes of years living with a disability. Between them, jaw pain and neck have been very prevalent among the general population. Subjects with chronic neck and jaw pain present with persistent pain, allodynia, …

back pain
chronic pain
pain relief
headache
hyperalgesia
  • 12 views
  • 26 Mar, 2022
Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation

In this pilot and feasibility study, the investigators will enroll patients with frequent symptomatic episodes of atrial fibrillation (AF) in a cross-over study testing two different classes of anti arrhythmic drugs (AADs). This pilot and feasibility study will provide preliminary data for a larger study in which the investigators will …

fibrillation
sotalol
flecainide
antiarrhythmic drug
  • 319 views
  • 08 Jul, 2022
  • 1 location
Cortical Network Modulation by Subthalamic Nucleus DBS

Deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson's disease (PD) can provide substantial motor benefit yet can also produce unwanted mood and cognitive side effects. Although the neural mechanisms underlying benefits and side effects are not well understood, current hypotheses center on the potentially measurable yet currently …

brain stimulation
Accepts healthy volunteers
  • 0 views
  • 15 Jun, 2022
  • 1 location
Post Coronavirus Disease (COVID-19) Syndrome Indonesian Population

Background and Objective Persistent symptoms after COVID 19 episodes (or referred to as Long COVID) can appear at a certain period and affect the quality of life of the patients, as well as introduce other comorbidities. It is important to address the associated factors of persistent symptoms after the COVID …

  • 0 views
  • 20 Jul, 2022
  • 2 locations
Delayed Breast Reconstruction by Prepectoral Implant After Lipo-preparation (RM2prepec) (RM2prepec)

outcomes. The objective of the subcutaneous positioning of this implant, is to reduce the muscular pain related to the stretching of the muscular muscle, the deformations related to the muscular

cancer
mastectomy
  • 50 views
  • 04 Mar, 2022
  • 1 location