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Found 33 clinical trials
Clinical Study and Gene Mutation Analysis of Adrenoleukodystrophy in Taiwanese Children

Study the clinical manifestations and gene mutation of Taiwanese ALD patients

mutation analysis
  • 0 views
  • 07 Nov, 2020
  • 1 location
Treatment Modification Based on Early Assessment of CML Patients

The investigators will check the feasibility of using early molecular response for making treatment decisions. Patients diagnosed with chronic myeloid leukemia will commence imatinib treatment. After 3 months of treatment their response will be assessed. If molecular response would be less the 10% (BCR-ABL1/ABL ISI >10%)imatinib therapy will be stopped …

philadelphia chromosome
dasatinib
tyrosine
nilotinib
leukemia
  • 5 views
  • 08 Nov, 2020
  • 1 location
Early Detection of High Grade Ovarian Cancer Using Uterine Lavage EHUD Study and Duplex Sequencing

In Phase I the sponsor will systematically test conditions for lavage filtration that increase tumor cell fraction without reducing tumor mutation yield. The Sponsor will also transition all lavages to luteal phase timing, when endometrial shedding is least. In Phase II the Sponsor will examine our data in context of …

  • 0 views
  • 07 Apr, 2021
  • 9 locations
DNA-mutation Analysis in Cyst Fluid of Suspected Intraductal Papillary Mucinous Neoplasia of the Pancreas

which are involved in advanced cysts with HGD or carcinoma. The ongoing ZYSTEUS-study tries to implement DNA mutation analysis by Next Generation Sequencing in the diagnostic algorithm of pancreas cyst

carcinoma
KRAS
pancreatic neoplasm
cyst
cancer
  • 0 views
  • 24 Jan, 2021
  • 1 location
Detection of Circulating Tumor DNA in p16- Locally Advanced Head Neck Squamous Cell Carcinoma

Locally advanced head and neck squamous cell carcinoma (LAHNSCC) is a heterogeneous disease, associated with a poor prognosis and no improvement in overall survival for years. Furthermore, treatments (surgery, radiotherapy, chemotherapy) are frequently associated with acute and late toxicities. Beside p16/HPV + tumors, only TNM classification can help estimating the …

TERT
squamous cell carcinoma
ESR1
KRAS
advanced head and neck squamous cell carcinoma
  • 0 views
  • 25 Jan, 2021
  • 2 locations
Enasidenib and Azacitidine in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia and IDH2 Gene Mutation

This phase II trial studies how well enasidenib and azacitidine work in treating patients with IDH2 gene mutation and acute myeloid leukemia that has come back (recurrent) or does not respond to treatment (refractory). Enasidenib and azacitidine may stop the growth of cancer cells by blocking some of the enzymes …

azacitidine
refractory acute myeloid leukemia (aml)
myeloid leukemia
myelomonocytic leukemia
enasidenib
  • 9 views
  • 23 Jan, 2021
  • 1 location
IDH2-Post-Allo-Trial for Patients With IDH2-mut Myeloid Neoplasms After Allo-SCT

This is a prospective, open label, multi-centre phase II trial with a two-arm non comparative design aiming to evaluate the safety and efficacy of Enasidenib (investigational product) as prophylactic consolidation in patients with IDH2-mutated MDS, CMML and AML in remission after allo-SCT and as salvage therapy in patients with IDH2-mutated …

graft versus host disease
enasidenib
chronic myelomonocytic leukemia
hydroxyurea
IDH2
  • 0 views
  • 26 Jan, 2021
  • 1 location
KEBI-Cyto Study - Use of the Biocartis Idylla

Use of the Biocartis Idylla platform for the detection of Epidermal Growth Factor Receptor, B-RAF and K-RAS proto-oncogene mutations in liquid based cytology specimens and blood plasma samples from patients with non small cell lung carcinoma and pancreatic adenocarcinoma.

carcinoma
lung carcinoma
epidermal growth factor
diagnostic procedures
adenocarcinoma
  • 0 views
  • 10 Mar, 2021
  • 1 location
Mutation Analysis of 17 hydroxysteroid Dehydrogenase 3 Deficiency

To disclose the molecular pathology of our 3 families with 17βHSD3 deficiency.

  • 9 views
  • 07 Nov, 2020
Analysis of Plasma Tumor DNA in Lung Cancer Patients

, good quality tumor tissues are available only in <50% of patients with inoperable lung cancer for mutation analysis. In this study, the investigators will detect and quantify the genetic

  • 3 views
  • 08 Nov, 2020
  • 1 location