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Found 64 clinical trials
Acute Response to Exercise in Patients With Rheumatoid Arthritis

sensitivity after an acute session of exercise will be assessed by the hyperinsulinemic euglycemic clamp, and the molecular pathways will be assessed by muscle biopsy and gene and protein expression analysis

edema
tocilizumab
tumour necrosis
tumor necrosis factor
  • 0 views
  • 04 Sep, 2021
  • 1 location
Protein Delivery in Intermittent and Continuous Enteral Nutrition in ICU Patients (ProBoNo)

care unit admission. Prior beginning of nutrition administration, and on the 7th day thereafter the investigators will perform a muscle biopsy and an ultrasound from the vastus lateralis muscle in both

Accepts healthy volunteers
  • 0 views
  • 05 Mar, 2022
  • 1 location
MABs Therapy m.3243A>G Mutation Carriers

Rationale: Mitochondrial disorders are progressive, often fatal multisystem disorders, in 20-25% of the cases caused by heteroplasmic mutations in the mitochondrial DNA (mtDNA). At this moment, there is no effective treatment known to influence the disease process or manifestation. Myogenic stem cell-based therapies complementing defective muscle cells and fibres, are …

  • 0 views
  • 07 Oct, 2021
  • 1 location
The Healthy Cookie Energy Study: Understanding How Healthy Cookies Affect Mitochondrial Biology (HCES)

The proposed research is an intervention and feasibility pilot trial designed to determine if short-term consumption of healthy cookies made with an oil rich in linoleic acid can influence mitochondria biology in white blood cells and muscle. The hypothesis of the study is that consuming 1 healthy cookie rich in …

Accepts healthy volunteers
  • 0 views
  • 24 Mar, 2022
  • 1 location
Enhancing Muscle Function After Exacerbations of COPD to Limit Its Impact on Physical Activity Decline

Patients with COPD lose muscle strength during acute exacerbations of COPD (AECOPD) which interferes improving the recovery of physical activity (PA) after an AECOPD. Resistance training can reverse this process. An exercise training program with the focus on resistance training is essential in minimizing the long-term effects of AECOPD as …

  • 0 views
  • 17 Mar, 2022
  • 2 locations
Influence of Dexmedetomidine or Propofol on ICU Delirium

In this randomized study, the investigators aim to test the hypothesis that the reinstitution of a normal circadian rhythm by continuous infusions of dexmedetomidine compared to propofol between 8pm and 6am after diagnosis of hyperactive or mixed delirium, decreases the duration of delirium. The infusions might have to be repeated …

dexmedetomidine
propofol
  • 0 views
  • 24 Apr, 2022
  • 1 location
Importance of Blood Volume and Its Interaction With Cardiovascular Adaptations

The present project aims to investigate the interaction between training-induced blood volume expansion (plasma- and red blood cell volume responses), central as well as peripheral cardio-vascular adaptations. We will investigate cardiovascular responses through one year of training in recreationally active men and women as well as endurance athletes undertaking shorter …

Accepts healthy volunteers
  • 0 views
  • 04 Jun, 2022
  • 2 locations
Variability of the Unique Fiber Potentials of a Spastic Muscle Treated With Botulinum Toxin (JITTOX)

The main objective is to study the variability and evolution of single-fiber jitter and fiber density (FD) electrophysiological parameters in a spastic muscle during botulinum toxin type A (BTA) treatment in hemiplegic patients after stroke, according to primary or multi-injected status. The secondary objectives of this study are: To establish …

Accepts healthy volunteers
  • 15 views
  • 26 Mar, 2022
  • 1 location
Study of SRP-4045 and SRP-4053 in Participants With Duchenne Muscular Dystrophy (DMD) (ESSENCE)

The main objective of this study is to evaluate the efficacy of SRP-4045 and SRP-4053 compared to placebo in participants with DMD with out-of-frame deletion mutations amenable to skipping exon 45 and exon 53, respectively.

duchenne muscular dystrophy
deletion mutation
muscular dystrophy
forced vital capacity
corticosteroids
  • 131 views
  • 25 Jan, 2022
  • 45 locations
The Effect of Various Strength Training Protocols in ACL Reconstructed Participants

therapy visits as long as they are part of the study The initial visit and follow up assessment at the end of the training will each take up to 6 hours (2 hours for MRI, 2 muscle biopsy, 2 for

imaging procedures
  • 974 views
  • 30 Jan, 2022
  • 1 location