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Found 148 clinical trials
Mucosal Immune Responses Against Neisseria Gonorrhoeae Following Meningococcal Immunization in Healthy Young Adults

This is a Phase 2 mechanistic clinical trial to assess the systemic and mucosal immunogenicity of the multicomponent meningococcal serogroup B vaccine (4CMenB or Bexsero (R)) (group 1, 40 subjects) against Neisseria gonorrhoeae, using a placebo vaccine (normal saline) as a comparator (group 2, 10 subjects). There will be approximately …

Accepts healthy volunteers
  • 0 views
  • 23 Oct, 2022
  • 1 location
Cultivated Autologous Oral Mucosal Epithelial Transplantation

Earlier protocol for cultivated oral mucosal epithelial transplantation (COMET) requires trypsin/EDTA to isolate epithelial cells from tissue, and uses murine 3T3 cells as feeder cells, which results in biosafety concern. This study uses collagenase instead of trypsin/EDTA to isolate epithelial cells, and does not use 3T3 cells co-culture, so as …

Accepts healthy volunteers
  • 24 views
  • 06 Feb, 2022
  • 1 location
Conventional Endoscopic Mucosal Resection Versus Cold Snare Endoscopic Mucosal Resection of Colonic Lateral Spreading Lesions - A Randomised Controlled Trial

Comparing the complete resection rate and subsequent adenoma recurrence rate at surveillance colonoscopy of 15-40mm laterally spreading adenomas for conventional EMR vs. cold snare EMR.

endoscopic mucosal resection
adenoma
cold
  • 0 views
  • 18 Feb, 2022
  • 1 location
Prospective Endoscopic Follow-up of Patients With Submucosal Esophageal Adenocarcinoma (The PREFER Trial)

Aim of this prospective multicenter study is to evaluate the safety of an endoscopic follow-up strategy in patients treated with endoscopic resection (ER) for submucosal or high-risk mucosal esophageal adenocarcinoma (T1bN0M0 or HR T1aN0M0 EAC).

endoscopic resection
esophageal adenocarcinoma
adenocarcinoma
  • 61 views
  • 29 Jan, 2021
  • 19 locations
Cold Snare Endoscopic Mucosal Resection Trial

This study compares different approaches to endoscopic mucosal resection (EMR) of large non-pedunculated colorectal polyps (20mm) in a 2 x 2 randomized design. The first randomization will assign half of patients to polyp resection with electrocautery ("hot" snare EMR) and half of patient to polyp resection without electrocautery ("cold" snare …

polypectomy
colorectal polyps
cold
colonoscopy
mucosal resection
  • 1 views
  • 10 Jun, 2021
  • 1 location
A Phase 2, Open-label, Multicenter, Cohort Study of Nemvaleukin Alfa (ALKS 4230) Monotherapy Administered Subcutaneously in Patients With Advanced Cutaneous Melanoma or Intravenously in Patients With Advanced Mucosal Melanoma Who Have Previously Received Anti-PD-[L]-1 Therapy - ARTISTRY-6 (ARTISTRY-6)

This study observes the antitumor activity, safety, tolerability, PK, and pharmacodynamics in patients with inoperable and/or metastatic melanoma following prior anti-PD-[L]-1 therapy

targeted therapy
immunologic adjuvant
metastatic melanoma
cytotoxic t-lymphocyte antigen 4
pembrolizumab
  • 3 views
  • 28 Oct, 2022
  • 28 locations
A Prospective, Randomized, Double-Blind, Sham-Controlled, Multi-Center Pivotal Study to Evaluate the Efficacy and Safety of Duodenal Mucosal Resurfacing Using the Revita® System in Subjects With Type 2 Diabetes on Insulin Therapy (REVITALIZE 1)

The Revita® system is being investigated to assess the efficacy of DMR versus Sham on improvement in Glycemic, Hepatic and Cardiovascular endpoints for patients with Type 2 Diabetes who are inadequately controlled with insulin therapy. The purpose of this study is to demonstrate the efficacy and safety of the Fractyl …

insulin
hemoglobin a1c
glycosylated hemoglobin
fasting
body mass index
  • 40 views
  • 28 Oct, 2022
  • 24 locations
Serum-derived Bovine Immunoglobulin Effect on Mucositis

The purpose of this cancer control clinical research study is to evaluate whether nutritional therapy with Serum-derived bovine immunoglobulin/protein isolate (SBI) might reduce mucositis (a

cancer
diarrhea
oral ulceration
  • 0 views
  • 27 Apr, 2022
  • 1 location
Photobiomodulation for the Prevention of Radiation Induced Oral Mucositis

Radiotherapy for head and neck cancer can cause severe mucositis (ulcers in the mouth) and pain. Photobiomodulation (Light therapy) will be used before and during radiotherapy to try to reduce

chemoradiotherapy
mucositis
  • 0 views
  • 23 Sep, 2021
  • 1 location
MucoLox Formulation to Mitigate Mucositis Symptoms in Head/Neck Cancer

result in significantly fewer subjects experiencing severe mucositis.

neck cancer
dental caries
cancer
cavity
sodium bicarbonate mouthwash
  • 37 views
  • 07 Oct, 2022
  • 1 location