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Found 15 clinical trials
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Neoadjuvant Nivolumab Plus Ipilimumab for Newly Diagnosed Malignant Peripheral Nerve Sheath Tumor

Neurofibromatosis Type 1 (NF1) and newly diagnosed pre-malignant and malignant peripheral nerve sheath tumors (MPNST) for whom surgery for resection of tumor is indicated.

  • 0 views
  • 19 Jun, 2021
  • 1 location
None
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial enrolls participants for …

ultrasound examination
infertility
bilateral oophorectomy
testicular
pheochromocytoma, malignant
  • 6055 views
  • 02 Dec, 2021
  • 820 locations
None
A Study of ASTX727 in People With Malignant Peripheral Nerve Sheath Tumors (MPNST)

The purpose of this study is to see whether the study drug ASTX727 is an effective treatment for people who have MPNST with a PCR2 mutation. ASTX727 is a combination of two drugs

  • 0 views
  • 27 Jun, 2021
  • 7 locations
None
A Study of APG-115 in Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors

and ATM mutation, P53 WT and MDM2 amplification liposarcomas, PD-1/PD-L1 refractory/relapsed urothelial carcinoma without FGFR translocation mutation, and MPNST.

STK11
pembrolizumab
lung adenocarcinoma
metastatic urothelial carcinoma
LKB1
  • 33 views
  • 23 Nov, 2021
  • 19 locations
None
PLX3397 Plus Sirolimus in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors

The purpose of this study is to determine if treatment with PLX3397 and Sirolimus will be tolerated and result in shrinking of the cancer or stopping the cancer from growing. In the phase I portion, the maximum tolerate dose of the study drug will be determined. In the Phase II …

cancer
solid tumour
neutrophil count
metastasis
small molecule
  • 0 views
  • 09 Sep, 2021
  • 5 locations
None
Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors

Background Metastasis is the spread of cancer from one organ to a nonadjacent organ. It causes 90% of cancer deaths. No treatment specifically prevents or reduces metastasis. Researchers hope a new drug can help. It stops cancer cells from growing and spreading further and possibly shrink cancer lesions in distant …

blood test
cancer
neutrophil count
ct scan
systemic chemotherapy
  • 0 views
  • 01 Dec, 2021
  • 2 locations
None
A Study of Different Dosing Schedules of Selinexor in Sarcoma Patients

metastatic malignant peripheral nerve sheath tumors (MPNST), endometrial stromal sarcomas (ESS) and leiomyosarcoma (LMS). Participants will continue on study until disease progression or unacceptable side

  • 0 views
  • 04 Apr, 2021
  • 1 location
None
EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

This is a phase I, open-label, non-randomized study that will enroll pediatric and young adult research participants with relapsed or refractory non-CNS solid tumors to evaluate the safety, feasibility, and efficacy of administering T cell products derived from the research participant's blood that have been genetically modified to express a …

mibg
apheresis
chemotherapy regimen
EGFR
metastatic disease
  • 308 views
  • 30 Apr, 2021
  • 1 location
None
B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

This is a phase I, open-label, non-randomized study that will enroll pediatric and young adult research participants with relapsed or refractory non-CNS solid tumors to evaluate the safety, feasibility, and efficacy of administering T cell products derived from the research participant's blood that have been genetically modified to express a …

mibg
apheresis
chemotherapy regimen
metastatic disease
stem cell transplantation
  • 0 views
  • 27 Apr, 2021
  • 1 location
None
Vaccine Therapy in Treating Patients With Malignant Peripheral Nerve Sheath Tumor That is Recurrent or Cannot Be Removed by Surgery

This phase I trial studies the side effects and the best dose of a vaccine therapy in treating patients with malignant peripheral nerve sheath tumor that cannot be removed by surgery (unresectable) or has come back after a period of improvement (recurrent). Vaccines made from a gene-modified virus may kill …

ct scan
absolute neutrophil count
measurable disease
tumor cells
  • 17 views
  • 25 Jun, 2021
  • 1 location